Protein name:
Low-density lipoprotein receptor-related protein 8 (LRP-8) ;
Alternative:
Apolipoprotein E receptor 2 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Reelin associates with two or more receptor molecules. Interacts with DAB1 and JNK-interacting proteins. Interacts with SNX17.
Function:
Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.
Subcellular Location:
Cell membrane
Single-pass type I membrane protein
Secreted
Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment.
Protein Attributes:
50:
MGLPEPGPLR | LLALLLLLLL | LLLLQLQHLA | AAAADPLLGG | QGPAKDCEKD |
100:
QFQCRNERCI | PSVWRCDEDD | DCLDHSDEDD | CPKKTCADSD | FTCDNGHCIH |
150:
ERWKCDGEEE | CPDGSDESEA | TCTKQVCPAE | KLSCGPTSHK | CVPASWRCDG |
200:
EKDCEGGADE | AGCATLCAPH | EFQCGNRSCL | AAVFVCDGDD | DCGDGSDERG |
250:
CADPACGPRE | FRCGGDGGGA | CIPERWVCDR | QFDCEDRSDE | AAELCGRPGP |
300:
GATSAPAACA | TASQFACRSG | ECVHLGWRCD | GDRDCKDKSD | EADCPLGTCR |
350:
GDEFQCGDGT | CVLAIKHCNQ | EQDCPDGSDE | AGCLQGLNEC | LHNNGGCSHI |
400:
CTDLKIGFEC | TCPAGFQLLD | QKTCGDIDEC | KDPDACSQIC | VNYKGYFKCE |
450:
CYPGYEMDLL | TKNCKAAAGK | SPSLIFTNRH | EVRRIDLVKR | NYSRLIPMLK |
500:
NVVALDVEVA | TNRIYWCDLS | YRKIYSAYMD | KASDPKEQEV | LIDEQLHSPE |
550:
GLAVDWVHKH | IYWTDSGNKT | ISVATVDGGR | RRTLFSRNLS | EPRAIAVDPL |
600:
RGFMYWSDWG | DQAKIEKSGL | NGVDRQTLVS | DNIEWPNGIT | LDLLSQRLYW |
650:
VDSKLHQLSS | IDFSGGNRKT | LISSTDFLSH | PFGIAVFEDK | VFWTDLENEA |
700:
IFSANRLNGL | EISILAENLN | NPHDIVIFHE | LKQPRAPDAC | ELSVQPNGGC |
750:
EYLCLPAPQI | SSHSPKYTCA | CPDTMWLGPD | MKRCYRAPQS | TSTTTLASTM |
800:
TRTVPATTRA | PGTTVHRSTY | QNHSTETPSL | TAAVPSSVSV | PRAPSISPST |
850:
LSPATSNHSQ | HYANEDSKMG | STVTAAVIGI | IVPIVVIALL | CMSGYLIWRN |
900:
WKRKNTKSMN | FDNPVYRKTT | EEEDEDELHI | GRTAQIGHVY | PAAISSFDRP |
950:
LWAEPCLGET | REPEDPAPAL | KELFVLPGEP | RSQLHQLPKN | PLSELPVVKS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
ELISA Kit for Human LRP-8
ELISA Kit for Human LRP-8
ELISA Kit for Human LRP-8
Polyclonal Antibody for Human LRP-8
Polyclonal Antibody for Human LRP-8
Polyclonal Antibody for Human LRP-8
Monoclonal Antibody for Human LRP-8
Monoclonal Antibody for Human LRP-8
Monoclonal Antibody for Human LRP-8
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Cited for : VARIANT GLN-952;CHARACTERIZATION OF VARIANT GLN-952;ASSOCIATION WITH SUSCEPTIBILITY TO MYOCARDIAL INFARCTION TYPE 1