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Index > Protein center > LRP8(Gene name) > Human
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  • LRP8 (Gene name),
  • Low-density lipoprotein receptor-related protein 8 (Protein name ),  LRP8_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    LRP8(APOER2);
    Protein name:
    Low-density lipoprotein receptor-related protein 8(LRP-8);
    Alternative:
    Apolipoprotein E receptor 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Reelin associates with two or more receptor molecules. Interacts with DAB1 and JNK-interacting proteins. Interacts with SNX17.
    Function:
    Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein Secreted Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment.
    Protein Attributes:
    Sequence length:
    963
    Sequence:
    50:
    MGLPEPGPLR | LLALLLLLLL | LLLLQLQHLA | AAAADPLLGG | QGPAKDCEKD | 
    100:
    QFQCRNERCI | PSVWRCDEDD | DCLDHSDEDD | CPKKTCADSD | FTCDNGHCIH | 
    150:
    ERWKCDGEEE | CPDGSDESEA | TCTKQVCPAE | KLSCGPTSHK | CVPASWRCDG | 
    200:
    EKDCEGGADE | AGCATLCAPH | EFQCGNRSCL | AAVFVCDGDD | DCGDGSDERG | 
    250:
    CADPACGPRE | FRCGGDGGGA | CIPERWVCDR | QFDCEDRSDE | AAELCGRPGP | 
    300:
    GATSAPAACA | TASQFACRSG | ECVHLGWRCD | GDRDCKDKSD | EADCPLGTCR | 
    350:
    GDEFQCGDGT | CVLAIKHCNQ | EQDCPDGSDE | AGCLQGLNEC | LHNNGGCSHI | 
    400:
    CTDLKIGFEC | TCPAGFQLLD | QKTCGDIDEC | KDPDACSQIC | VNYKGYFKCE | 
    450:
    CYPGYEMDLL | TKNCKAAAGK | SPSLIFTNRH | EVRRIDLVKR | NYSRLIPMLK | 
    500:
    NVVALDVEVA | TNRIYWCDLS | YRKIYSAYMD | KASDPKEQEV | LIDEQLHSPE | 
    550:
    GLAVDWVHKH | IYWTDSGNKT | ISVATVDGGR | RRTLFSRNLS | EPRAIAVDPL | 
    600:
    RGFMYWSDWG | DQAKIEKSGL | NGVDRQTLVS | DNIEWPNGIT | LDLLSQRLYW | 
    650:
    VDSKLHQLSS | IDFSGGNRKT | LISSTDFLSH | PFGIAVFEDK | VFWTDLENEA | 
    700:
    IFSANRLNGL | EISILAENLN | NPHDIVIFHE | LKQPRAPDAC | ELSVQPNGGC | 
    750:
    EYLCLPAPQI | SSHSPKYTCA | CPDTMWLGPD | MKRCYRAPQS | TSTTTLASTM | 
    800:
    TRTVPATTRA | PGTTVHRSTY | QNHSTETPSL | TAAVPSSVSV | PRAPSISPST | 
    850:
    LSPATSNHSQ | HYANEDSKMG | STVTAAVIGI | IVPIVVIALL | CMSGYLIWRN | 
    900:
    WKRKNTKSMN | FDNPVYRKTT | EEEDEDELHI | GRTAQIGHVY | PAAISSFDRP | 
    950:
    LWAEPCLGET | REPEDPAPAL | KELFVLPGEP | RSQLHQLPKN | PLSELPVVKS | 
    963:
    KRVALSLEDD | GLP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    MIM:
    String:
    KEGG:
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human LRP-8
    Cat.:
    E10006h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human LRP-8
    MSDS:
    Please sign in first.
    ELISA Kit for Human LRP-8
    Cat.:
    E10006m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human LRP-8
    MSDS:
    Please sign in first.
    CLIA Kit for Human LRP-8
    Cat.:
    U10006h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human LRP-8
    Cat.:
    U10006m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human LRP-8
    Cat.:
    P10006Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LRP-8
    Polyclonal Antibody for Human LRP-8
    Monoclonal Antibody for Human LRP-8
    Monoclonal Antibody for Human LRP-8
    Monoclonal Antibody for Human LRP-8
    Protein for Human LRP-8
    Protein for Human LRP-8
    Protein for Human LRP-8

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain."
      Kim D.-H. , Iijima H. , Goto K. , Sakai J. , Ishii H. , Kim H.-J. , Suzuki H. , Kondo H. , Saeki S. , Yamamoto T.
      J. Biol. Chem.271:8373-8380(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-25 AND GLU-46
      tissue: Placenta.
    2. 2.
      "Exon/intron organization, chromosome localization, alternative splicing, and transcription units of the human apolipoprotein E receptor 2 gene."
      Kim D.-H. , Magoori K. , Inoue T.R. , Mao C.C. , Kim H.-J. , Suzuki H. , Fujita T. , Endo Y. , Saeki S. , Yamamoto T.T.
      J. Biol. Chem.272:8498-8504(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 4);VARIANTS ARG-25 AND GLU-46
      tissue: Peripheral blood.
    3. 3.
      "Identification of a novel exon in apolipoprotein E receptor 2 leading to alternatively spliced mRNAs found in cells of the vascular wall but not in neuronal tissue."
      Korschineck I. , Ziegler S. , Breuss J. , Lang I. , Lorenz M. , Kaun C. , Ambros P.F. , Binder B.R.
      J. Biol. Chem.276:13192-13197(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANTS ARG-25 AND GLU-46
      tissue: Umbilical vein.
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 720-963 (ISOFORM 1);VARIANTS ARG-25 AND GLU-46
      tissue: Eye.
      tissue: Lung.
    6. 6.
      "Expression and alternate splicing of apolipoprotein E receptor 2 in brain."
      Clatworthy A.E. , Stockinger W. , Christie R.H. , Schneider W.J. , Nimpf J. , Hyman B.T. , Rebeck G.W.
      Neuroscience90:903-911(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;TISSUE SPECIFICITY
    7. 7.
      "Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in endothelial cells."
      Sacre S.M. , Stannard A.K. , Owen J.S.
      FEBS Lett.540:181-187(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYROSINE RESIDUES
    8. 8.
      "Identification and characterization of LRP8 (apoER2) in human blood platelets."
      Riddell D.R. , Vinogradov D.V. , Stannard A.K. , Chadwick N. , Owen J.S.
      J. Lipid Res.40:1925-1930(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;TISSUE SPECIFICITY
    9. 9.
      "Differential binding of ligands to the apolipoprotein E receptor 2."
      Andersen O.M. , Benhayon D. , Curran T. , Willnow T.E.
      Biochemistry42:9355-9364(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A RECEPTOR FOR REELIN
    10. 10.
      "Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain."
      Li X. , Kypreos K. , Zanni E.E. , Zannis V.
      Biochemistry42:10406-10417(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A RECEPTOR FOR APOE
    11. 11.
      "Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'."
      Lutters B.C. , Derksen R.H. , Tekelenburg W.L. , Lenting P.J. , Arnout J. , de Groot P.G.
      J. Biol. Chem.278:33831-33838(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A RECEPTOR FOR BETA 2-GLYCOPROTEIN I
    12. 12.
      "The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2."
      Poirier S. , Mayer G. , Benjannet S. , Bergeron E. , Marcinkiewicz J. , Nassoury N. , Mayer H. , Nimpf J. , Prat A. , Seidah N.G.
      J. Biol. Chem.283:2363-2372(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PCSK9
    13. 13.
      "The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2."
      Hong C. , Duit S. , Jalonen P. , Out R. , Scheer L. , Sorrentino V. , Boyadjian R. , Rodenburg K.W. , Foley E. , Korhonen L. , Lindholm D. , Nimpf J. , van Berkel T.J. , Tontonoz P. , Zelcer N.
      J. Biol. Chem.285:19720-19726(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
    14. 14.
      "Low-density lipoprotein receptor-related protein 8 (apolipoprotein E receptor 2) gene polymorphisms in Alzheimer's disease."
      Ma S.L. , Ng H.K. , Baum L. , Pang J.C. , Chiu H.F. , Woo J. , Tang N.L. , Lam L.C.
      Neurosci. Lett.332:216-218(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLU-46 AND GLN-952
    15. 15.
      "An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarction."
      Shen G.-Q. , Li L. , Girelli D. , Seidelmann S.B. , Rao S. , Fan C. , Park J.E. , Xi Q. , Li J. , Hu Y. , Olivieri O. , Marchant K. , Barnard J. , Corrocher R. , Elston R. , Cassano J. , Henderson S. , Hazen S.L. , more...
      Am. J. Hum. Genet.81:780-791(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLN-952;CHARACTERIZATION OF VARIANT GLN-952;ASSOCIATION WITH SUSCEPTIBILITY TO MYOCARDIAL INFARCTION TYPE 1
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