LHCGR ELISA Kit for Human(Homo sapiens) | EIAab.comLHCGR ELISA Kit for Human(Homo sapiens)

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Index > Protein center > LHCGR(Gene name) > Human

LHCGR (Gene name),

Lutropin-choriogonadotropic hormone receptor (Protein name ), LSHR_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

LHCGR(LCGR;LGR2;LHRHR);

Protein name:

Lutropin-choriogonadotropic hormone receptor(LH/CG-R);

Alternative:

Luteinizing hormone receptor(LHR;LSH-R);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

699

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

699:

YRRKDFSAYT | SNCKNGFTGS | NKPSQSTLKL | STLHCQGTAL | LDKTRYTEC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P22888

Pfam:

PF00001

UniGene:

Hs.468490

String:

P22888

MIM:

152790

STRING:

9606.ENSP00000294954

KEGG:

hsa:3973

Uniprot:

P22888

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ELISA Kit for Human LH/CG-R

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E1430h

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ELISA Kit for Human LH/CG-R

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E1430m

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96T

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ELISA Kit for Human LH/CG-R

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E1430b

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ELISA Kit for Human LH/CG-R

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E1430r

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ELISA Kit for Human LH/CG-R

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E1430p

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96T

ELISA Kit for Human LH/CG-R

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E1430c

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96T

CLIA Kit for Human LH/CG-R

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U1430c

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96T

CLIA Kit for Human LH/CG-R

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U1430r

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96T

CLIA Kit for Human LH/CG-R

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U1430p

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96T

CLIA Kit for Human LH/CG-R

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U1430b

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96T

CLIA Kit for Human LH/CG-R

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U1430h

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96T

CLIA Kit for Human LH/CG-R

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U1430m

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96T

Polyclonal Antibody for Human LH/CG-R

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P1430Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human LH/CG-R

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P1430Rb-r

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Polyclonal Antibody for Human LH/CG-R

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P1430Rb-h

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Polyclonal Antibody for Human LH/CG-R

Monoclonal Antibody for Human LH/CG-R

Protein for Human LH/CG-R

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Cloning and sequencing of human LH/hCG receptor cDNA."
Minegish T. , Nakamura K. , Takakura Y. , Miyamoto K. , Hasegawa Y. , Ibuki Y. , Igarashi M.
Biochem. Biophys. Res. Commun.172:1049-1054(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-312
tissue: Ovary.
2.

"Expression of human luteinizing hormone (LH) receptor: interaction with LH and chorionic gonadotropin from human but not equine, rat, and ovine species."
Jia X.-C. , Oikawa M. , Bo M. , Tanaka T. , Ny T. , Boime I. , Hsueh A.J.W.
Mol. Endocrinol.5:759-768(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Ovary.
3.

"Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing."
Frazier A.L. , Robbins L.S. , Stork P.J. , Sprengel R. , Segaloff D.L. , Cone R.D.
Mol. Endocrinol.4:1264-1276(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Thyroid.
4.

"Structure of the human luteinizing hormone-choriogonadotropin receptor gene: unusual promoter and 5' non-coding regions."
Atger M. , Misrahi M. , Sar S. , Leflem L. , Dessen P. , Milgrom E.
Mol. Cell. Endocrinol.111:113-123(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LEU-GLN-18 INS AND SER-312
5.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"Genomic distribution and gonadal mRNA expression of two human luteinizing hormone receptor exon 1 sequences in random populations."
Tsai-Morris C.-H. , Geng Y. , Buczko E. , Dehejia A. , Dufau M.L.
Hum. Hered.49:48-51(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-54;VARIANT LEU-GLN-18 INS
7.

"Evidence that palmitoylation of carboxyl terminus cysteine residues of the human luteinizing hormone receptor regulates postendocytic processing."
Munshi U.M. , Clouser C.L. , Peegel H. , Menon K.M.
Mol. Endocrinol.19:749-758(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-643 AND CYS-644;MUTAGENESIS OF CYS-643 AND CYS-644
8.

"Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions."
Jiang X. , Dreano M. , Buckler D.R. , Cheng S. , Ythier A. , Wu H. , Hendrickson W.A. , el Tayar N.
Structure3:1341-1353(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF 51-232
9.

"Gonadotropin-independent precocious puberty due to luteinizing hormone receptor mutations in Brazilian boys: a novel constitutively activating mutation in the first transmembrane helix."
Latronico A.C. , Shinozaki H. , Guerra G. Jr. , Pereira M.A.A. , Lemos Marini S.H.V. , Baptista M.T.M. , Arnhold I.J.P. , Fanelli F. , Mendonca B.B. , Segaloff D.L.
J. Clin. Endocrinol. Metab.85:4799-4805(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FMPP PRO-368 AND VAL-568;CHARACTERIZATION OF VARIANT FMPP PRO-368
10.

"Nodular Leydig cell hyperplasia in a boy with familial male-limited precocious puberty."
Leschek E.W. , Chan W.-Y. , Diamond D.A. , Kaefer M. , Jones J. , Barnes K.M. , Cutler G.B. Jr.
J. Pediatr.138:949-951(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FMPP GLY-564
11.

"Mutant luteinizing hormone receptors in a compound heterozygous patient with complete Leydig cell hypoplasia: abnormal processing causes signaling deficiency."
Martens J.W.M. , Lumbroso S. , Verhoef-Post M. , Georget V. , Richter-Unruh A. , Szarras-Czapnik M. , Romer T.E. , Brunner H.G. , Themmen A.P.N. , Sultan C.
J. Clin. Endocrinol. Metab.87:2506-2513(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LHR SER-343 AND ARG-543;CHARACTERIZATION OF VARIANTS LHR SER-343 AND ARG-543
12.

"Luteinizing hormone signaling and breast cancer: polymorphisms and age of onset."
Powell B.L. , Piersma D. , Kevenaar M.E. , van Staveren I.L. , Themmen A.P.N. , Iacopetta B.J. , Berns E.M.J.J.
J. Clin. Endocrinol. Metab.88:1653-1657(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION OF VARIANT LEU-GLN-18 INS WITH AGE OF BREAST CANCER ONSET
13.

"A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty."
Shenker A. , Laue L. , Kosugi S. , Merendino J.J. Jr. , Minegishi T. , Cutler G.B. Jr.
Nature365:652-654(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FMPP GLY-578
14.

"Cosegregation of missense mutations of the luteinizing hormone receptor gene with familial male-limited precocious puberty."
Kremer H. , Mariman E. , Otten B.J. , Moll G.W. Jr. , Stoelinga G.B.A. , Wit J.M. , Jansen M. , Drop S.L. , Faas B. , Ropers H.-H. , Brunner H.G.
Hum. Mol. Genet.2:1779-1783(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FMPP ILE-571 AND GLY-578
15.

"Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty."
Kosugi S. , van Dop C. , Geffner M.E. , Rabl W. , Carel J.-C. , Chaussain J.-L. , Mori T. , Merendino J.J. Jr. , Shenker A.
Hum. Mol. Genet.4:183-188(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FMPP ILE-577
16.

"A new constitutively activating point mutation in the luteinizing hormone/choriogonadotropin receptor gene in cases of male-limited precocious puberty."
Yano K. , Saji M. , Hidaka A. , Moriya N. , Okuno A. , Kohn L.D. , Cutler G.B. Jr.
J. Clin. Endocrinol. Metab.80:1162-1168(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FMPP VAL-572
17.

"A novel mutation of the luteinizing hormone receptor gene causing male gonadotropin-independent precocious puberty."
Latronico A.C. , Anasti J. , Arnhold I.J. , Mendonca B.B. , Domenice S. , Albano M.C. , Zachman K. , Wajchenberg B.L. , Tsigos C.
J. Clin. Endocrinol. Metab.80:2490-2494(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FMPP VAL-568
18.

"Male pseudohermaphroditism due to a homozygous missense mutation of the luteinizing hormone receptor gene."
Kremer H. , Kraaij R. , Toledo S.P.A. , Post M. , Fridman J.B. , Hayashida C.Y. , van Reen M. , Milgrom E. , Ropers H.-H. , Mariman E. , Themmen A.P.N. , Brunner H.G.
Nat. Genet.9:160-164(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LHR PRO-593
19.

"A missense (T577I) mutation in the luteinizing hormone receptor gene associated with familial male-limited precocious puberty."
Cocco S. , Meloni A. , Marini M.G. , Cao A. , Moi P.
Hum. Mutat.7:164-166(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FMPP ILE-577
20.

"A new point mutation in the luteinising hormone receptor gene in familial and sporadic male limited precocious puberty: genotype does not always correlate with phenotype."
Evans B.A.J. , Bowen D.J. , Smith P.J. , Clayton P.E. , Gregory J.W.
J. Med. Genet.33:143-147(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FMPP THR-398
21.

"Testicular and ovarian resistance to luteinizing hormone caused by inactivating mutations of the luteinizing hormone-receptor gene."
Latronico A.C. , Anasti J. , Arnhold I.J.P. , Rapaport R. , Mendonca B.B. , Bloise W. , Castro M. , Tsigos C. , Chrousos G.P.
N. Engl. J. Med.334:507-512(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LHR TYR-616
22.

"Comparison of immunocytochemical and molecular features with the phenotype in a case of incomplete male pseudohermaphroditism associated with a mutation of the luteinizing hormone receptor."
Misrahi M. , Meduri G. , Pissard S. , Bouvattier C. , Beau I. , Loosfelt H. , Jolivet A. , Rappaport R. , Milgrom E. , Bougneres P.
J. Clin. Endocrinol. Metab.82:2159-2165(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LHR ARG-131
23.

"Polymorphisms in the coding exons of the human luteinizing hormone receptor gene."
Wu S.-M. , Jose M. , Hallermeier K. , Rennert O.M. , Chan W.-Y.
Hum. Mutat.11:333-334(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEU-GLN-18 INS; SER-284 AND ASN-306
24.

"A mutation in the first transmembrane domain of the lutropin receptor causes male precocious puberty."
Gromoll J. , Partsch C.-J. , Simoni M. , Nordhoff V. , Sippell W.G. , Nieschlag E. , Saxena B.B.
J. Clin. Endocrinol. Metab.83:476-480(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FMPP VAL-373
25.

"A novel mutation of the human luteinizing hormone receptor in 46XY and 46XX sisters."
Stavrou S.S. , Zhu Y.S. , Cai L.Q. , Katz M.D. , Herrera C. , Defillo-Ricart M. , Imperato-Mcginley J.
J. Clin. Endocrinol. Metab.83:2091-2098(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LHR LYS-354
26.

"A unique constitutively activating mutation in third transmembrane helix of luteinizing hormone receptor causes sporadic male gonadotropin-independent precocious puberty."
Latronico A.C. , Abell A.N. , Arnhold I.J. , Liu X. , Lins T.S. , Brito V.N. , Billerbeck A.E. , Segaloff D.L. , Mendonca B.B.
J. Clin. Endocrinol. Metab.83:2435-2440(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FMPP ARG-457
27.

"Evidences for an allelic variant of the human LC/CG receptor rather than a gene duplication: functional comparison of wild-type and variant receptors."
Rodien P. , Cetani F. , Costagliola S. , Tonacchera M. , Duprez L. , Minegishi T. , Govaerts C. , Vassart G.
J. Clin. Endocrinol. Metab.83:4431-4434(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-GLN-18 INS
28.

"A homozygous microdeletion in helix 7 of the luteinizing hormone receptor associated with familial testicular and ovarian resistance is due to both decreased cell surface expression and impaired effector activation by the cell surface receptor."
Latronico A.C. , Chai Y. , Arnhold I.J.P. , Liu X. , Mendonca B.B. , Segaloff D.L.
Mol. Endocrinol.12:442-450(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LHR 608-LEU-VAL-609 DEL
29.

"A homozygous mutation in the luteinizing hormone receptor causes partial Leydig cell hypoplasia: correlation between receptor activity and phenotype."
Martens J.W. , Verhoef-Post M. , Abelin N. , Ezabella M. , Toledo S.P. , Brunner H.G. , Themmen A.P.
Mol. Endocrinol.12:775-784(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LHR LYS-625
30.

"Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor."
Liu G. , Duranteau L. , Carel J.-C. , Monroe J. , Doyle D.A. , Shenker A.
N. Engl. J. Med.341:1731-1736(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEYDIG CELL TUMOR HIS-578
31.

"A novel missense homozygous inactivating mutation in the fourth transmembrane helix of the luteinizing hormone receptor in Leydig cell hypoplasia."
Leung M.Y.-K. , Al-Muslim O. , Wu S.-M. , Aziz A. , Inam S. , Awadh M. , Rennert O.M. , Chan W.-Y.
Am. J. Med. Genet. A130:146-153(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LHR PRO-502;CHARACTERIZATION OF VARIANT LCH PRO-502
32.

"Leydig cell hypoplasia: absent luteinizing hormone receptor cell surface expression caused by a novel homozygous mutation in the extracellular domain."
Richter-Unruh A. , Verhoef-Post M. , Malak S. , Homoki J. , Hauffa B.P. , Themmen A.P.N.
J. Clin. Endocrinol. Metab.89:5161-5167(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LHR PHE-144;CHARACTERIZATION OF VARIANT LCH PHE-144
33.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-564
34.

"A splice site mutation combined with a novel missense mutation of LHCGR cause male pseudohermaphroditism."
Qiao J. , Han B. , Liu B.-L. , Chen X. , Ru Y. , Cheng K.-X. , Chen F.-G. , Zhao S.-X. , Liang J. , Lu Y.-L. , Tang J.-F. , Wu Y.-X. , Wu W.-L. , Chen J.-L. , Chen M.-D. , Song H.-D.
Hum. Mutat.30:E855-E865(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LHR THR-152;CHARACTERIZATION OF VARIANT LHR THR-152

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