MAP3K1 ELISA Kit for Human(Homo sapiens) | EIAab.comMAP3K1 ELISA Kit for Human(Homo sapiens) | EIAab.com

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MAP3K1 (Gene name),

Mitogen-activated protein kinase kinase kinase 1 (Protein name ), M3K1_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

MAP3K1(MAPKKK1;MEKK;MEKK1);

Protein name:

Mitogen-activated protein kinase kinase kinase 1;

Alternative:

MAPK/ERK kinase kinase 1(MEK kinase 1;MEKK 1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds both upstream activators and downstream substrates in multimolecular complexes through its N-terminus. Oligomerizes after binding MAP4K2 or TRAF2. Interacts with AXIN1. Interacts (via the kinase catalytic domain) with STK38.

Function:

Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

1512

Sequence:

50:

MAAAAGNRAS | SSGFPGARAT | SPEAGGGGGA | LKASSAPAAA | AGLLREAGSG |

100:

GRERADWRRR | QLRKVRSVEL | DQLPEQPLFL | AASPPASSTS | PSPEPADAAG |

150:

SGTGFQPVAV | PPPHGAASRG | GAHLTESVAA | PDSGASSPAA | AEPGEKRAPA |

200:

AEPSPAAAPA | GREMENKETL | KGLHKMDDRP | EERMIREKLK | ATCMPAWKHE |

250:

WLERRNRRGP | VVVKPIPVKG | DGSEMNHLAA | ESPGEVQASA | ASPASKGRRS |

300:

PSPGNSPSGR | TVKSESPGVR | RKRVSPVPFQ | SGRITPPRRA | PSPDGFSPYS |

350:

PEETNRRVNK | VMRARLYLLQ | QIGPNSFLIG | GDSPDNKYRV | FIGPQNCSCA |

400:

RGTFCIHLLF | VMLRVFQLEP | SDPMLWRKTL | KNFEVESLFQ | KYHSRRSSRI |

450:

KAPSRNTIQK | FVSRMSNSHT | LSSSSTSTSS | SENSIKDEEE | QMCPICLLGM |

500:

LDEESLTVCE | DGCRNKLHHH | CMSIWAEECR | RNREPLICPL | CRSKWRSHDF |

550:

YSHELSSPVD | SPSSLRAAQQ | QTVQQQPLAG | SRRNQESNFN | LTHYGTQQIP |

600:

PAYKDLAEPW | IQVFGMELVG | CLFSRNWNVR | EMALRRLSHD | VSGALLLANG |

650:

ESTGNSGGSS | GSSPSGGATS | GSSQTSISGD | VVEACCSVLS | MVCADPVYKV |

700:

YVAALKTLRA | MLVYTPCHSL | AERIKLQRLL | QPVVDTILVK | CADANSRTSQ |

750:

LSISTLLELC | KGQAGELAVG | REILKAGSIG | IGGVDYVLNC | ILGNQTESNN |

800:

WQELLGRLCL | IDRLLLEFPA | EFYPHIVSTD | VSQAEPVEIR | YKKLLSLLTF |

850:

ALQSIDNSHS | MVGKLSRRIY | LSSARMVTTV | PHVFSKLLEM | LSVSSSTHFT |

900:

RMRRRLMAIA | DEVEIAEAIQ | LGVEDTLDGQ | QDSFLQASVP | NNYLETTENS |

950:

SPECTVHLEK | TGKGLCATKL | SASSEDISER | LASISVGPSS | STTTTTTTTE |

1000:

QPKPMVQTKG | RPHSQCLNSS | PLSHHSQLMF | PALSTPSSST | PSVPAGTATD |

1050:

VSKHRLQGFI | PCRIPSASPQ | TQRKFSLQFH | RNCPENKDSD | KLSPVFTQSR |

1100:

PLPSSNIHRP | KPSRPTPGNT | SKQGDPSKNS | MTLDLNSSSK | CDDSFGCSSN |

1150:

SSNAVIPSDE | TVFTPVEEKC | RLDVNTELNS | SIEDLLEASM | PSSDTTVTFK |

1200:

SEVAVLSPEK | AENDDTYKDD | VNHNQKCKEK | MEAEEEEALA | IAMAMSASQD |

1250:

ALPIVPQLQV | ENGEDIIIIQ | QDTPETLPGH | TKAKQPYRED | TEWLKGQQIG |

1300:

LGAFSSCYQA | QDVGTGTLMA | VKQVTYVRNT | SSEQEEVVEA | LREEIRMMSH |

1350:

LNHPNIIRML | GATCEKSNYN | LFIEWMAGGS | VAHLLSKYGA | FKESVVINYT |

1400:

EQLLRGLSYL | HENQIIHRDV | KGANLLIDST | GQRLRIADFG | AAARLASKGT |

1450:

GAGEFQGQLL | GTIAFMAPEV | LRGQQYGRSC | DVWSVGCAII | EMACAKPPWN |

1500:

AEKHSNHLAL | IFKIASATTA | PSIPSHLSPG | LRDVALRCLE | LQPQDRPPSR |

1512:

ELLKHPVFRT | TW

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

MIM:

UniGene:

KEGG:

Pfam:

STRING:

9606.ENSP00000382423

String:

Uniprot:

FOR

ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 1

ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 1

ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 1

CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 1

CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 1

CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 1

Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 1

Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 1

Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 1

Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 1

Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 1

Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 1

Protein for Human Mitogen-activated protein kinase kinase kinase 1

Protein for Human Mitogen-activated protein kinase kinase kinase 1

Protein for Human Mitogen-activated protein kinase kinase kinase 1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J. , Martin J. , Terry A. , Couronne O. , Grimwood J. , Lowry S. , Gordon L.A. , Scott D. , Xie G. , Huang W. , Hellsten U. , Tran-Gyamfi M. , She X. , Prabhakar S. , Aerts A. , Altherr M. , Bajorek E. , Black S. , more...
Nature431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
2.

"JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension."
Xia Y. , Wu Z. , Su B. , Murray B. , Karin M.
Genes Dev.12:3369-3381(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-1512;FUNCTION;INTERACTION WITH MAP2K4
3.

"Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5."
Vinik B.S. , Kay E.S. , Fiedorek F.T. Jr.
Mamm. Genome6:782-783(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1238-1274
tissue: Leukocyte.
4.

"SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling."
Rui H.L. , Fan E. , Zhou H.M. , Xu Z. , Zhang Y. , Lin S.C.
J. Biol. Chem.277:42981-42986(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AXIN1
5.

"The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms."
Wong C.K. , Luo W. , Deng Y. , Zou H. , Ye Z. , Lin S.-C.
J. Biol. Chem.279:39366-39373(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AXIN1
6.

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-292;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
7.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-154 AND SER-1043;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
8.

"Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38)."
Enomoto A. , Kido N. , Ito M. , Morita A. , Matsumoto Y. , Takamatsu N. , Hosoi Y. , Miyagawa K.
Oncogene27:1930-1938(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STK38
9.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-292; SER-297; SER-300; SER-507 AND SER-1018;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
11.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-275 AND SER-292;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-92 AND SER-443
13.

"Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination."
Pearlman A. , Loke J. , Le Caignec C. , White S. , Chin L. , Friedman A. , Warr N. , Willan J. , Brauer D. , Farmer C. , Brooks E. , Oddoux C. , Riley B. , Shajahan S. , Camerino G. , Homfray T. , Crosby A.H. , Couper J. , more...
Am. J. Hum. Genet.87:898-904(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SRXY6 PRO-189; ARG-189; ILE-GLN-211 INS AND ARG-616;CHARACTERIZATION OF VARIANTS SRXY6 PRO-189 AND ARG-189

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