Macf1 ELISA Kit for Mouse(Mus musculus) | EIAab.comMacf1 ELISA Kit for Mouse(Mus musculus)

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Macf1 (Gene name),

Microtubule-actin cross-linking factor 1 (Protein name ), MACF1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Macf1(Acf7;Aclp7;Macf);

Protein name:

Microtubule-actin cross-linking factor 1;

Alternative:

Actin cross-linking family 7;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Isoform 2 interacts with AXIN1, LRP6 and GOLGA4 (By similarity). Isoform 2 is found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (By similarity). Isoform 2 interacts with MAPRE1, CLASP1 AND CLASP2.

Function:

Isoform 2 is a F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells.

Subcellular Location:

Isoform 1 Cytoplasm Golgi apparatus

Protein Attributes:

Sequence length:

7354

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GPKR

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

UniGene:

Mm.402299

Pfam:

PF00307

String:

Q9QXZ0

STRING:

10090.ENSMUSP00000081324

SMR:

Q9QXZ0

Uniprot:

Q9QXZ0

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ELISA Kit for Mouse Microtubule-actin cross-linking factor 1

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E15471r

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ELISA Kit for Mouse Microtubule-actin cross-linking factor 1

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E15471h

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ELISA Kit for Mouse Microtubule-actin cross-linking factor 1

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E15471m

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ELISA Kit for Mouse Microtubule-actin cross-linking factor 1

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E15471h

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96T

CLIA Kit for Mouse Microtubule-actin cross-linking factor 1

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U15471h

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96T

CLIA Kit for Mouse Microtubule-actin cross-linking factor 1

Cat.:

U15471m

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96T

CLIA Kit for Mouse Microtubule-actin cross-linking factor 1

Cat.:

U15471h

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MSDS:

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96T

CLIA Kit for Mouse Microtubule-actin cross-linking factor 1

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U15471r

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Polyclonal Antibody for Mouse Microtubule-actin cross-linking factor 1

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P15471Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Microtubule-actin cross-linking factor 1

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P15471Rb-m

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Polyclonal Antibody for Mouse Microtubule-actin cross-linking factor 1

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P15471Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Microtubule-actin cross-linking factor 1

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P15471Rb-h

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Monoclonal Antibody for Mouse Microtubule-actin cross-linking factor 1

Protein for Mouse Microtubule-actin cross-linking factor 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Microtubule actin cross-linking factor (MACF): a hybrid of dystonin and dystrophin that can interact with the actin and microtubule cytoskeletons."
Leung C.L. , Sun D. , Zheng M. , Knowles D.R. , Liem R.K.H.
J. Cell Biol.147:1275-1286(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain: BALB/c.
2.

"Microtubule actin crosslinking factor 1b: a novel plakin that localizes to the Golgi complex."
Lin C.-M. , Chen H.-J. , Leung C.L. , Parry D.A.D. , Liem R.K.H.
J. Cell Sci.118:3727-3738(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
strain: BALB/c.
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

"Cloning and characterization of mouse ACF7, a novel member of the dystonin subfamily of actin binding proteins."
Bernier G. , Mathieu M. , De Repentigny Y. , Vidal S.M. , Kothary R.
Genomics38:19-29(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-3909 (ISOFORMS 2 AND 4);PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
strain: BALB/c.
tissue: Brain.
5.

Lubec G. , Kang S.U.
Submitted (2007-04) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 881-888; 5824-5832 AND 6671-6678;IDENTIFICATION BY MASS SPECTROMETRY
strain: C57BL/6.
tissue: Brain.
6.

"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A. , Villen J. , Beausoleil S.A. , Schwartz D. , Gygi S.P.
Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic brain.
7.

"The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway."
Chen H.J. , Lin C.M. , Lin C.S. , Perez-Olle R. , Leung C.L. , Liem R.K.
Genes Dev.20:1933-1945(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
8.

"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain.
9.

"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P. , Tweedie-Cullen R. , Livingstone-Zatchej M. , Weinandy F. , Waidelich M. , Longo D. , Gehrig P. , Potthast F. , Rutishauser D. , Gerrits B. , Panse C. , Schlapbach R. , Mansuy I.M.
Mol. Cell. Proteomics6:283-293(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain cortex.
10.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3082; SER-3085; SER-7296 AND SER-7299;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
11.

"ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity."
Wu X. , Kodama A. , Fuchs E.
Cell135:137-148(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH MAPRE1; CLASP1 AND CLASP2
12.

"Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3beta."
Wu X. , Shen Q.T. , Oristian D.S. , Lu C.P. , Zheng Q. , Wang H.W. , Fuchs E.
Cell144:341-352(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;IDENTIFICATION BY MASS SPECTROMETRY;SUBCELLULAR LOCATION;TISSUE SPECIFICITY

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