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Index > Protein center > MAEA(Gene name) > Human
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  • MAEA (Gene name),
  • Macrophage erythroblast attacher (Protein name ),  MAEA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MAEA(HLC10;PIG5;EMP);
    Protein name:
    Macrophage erythroblast attacher;
    Alternative:
    Erythroblast macrophage protein;Cell proliferation-inducing gene 5 protein;Human lung cancer oncogene 10 protein(HLC-10);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms a complex with F-actin.
    Function:
    Play a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events.
    Subcellular Location:
    Nucleus matrix Cell membrane Cytoplasm cytoskeleton Localized as nuclear speckled-like pattern.
    Protein Attributes:
    Sequence length:
    396
    Sequence:
    50:
    MAVQESAAQL | SMTLKVQEYP | TLKVPYETLN | KRFRAAQKNI | DRETSHVTMV | 
    100:
    VAELEKTLSG | CPAVDSVVSL | LDGVVEKLSV | LKRKAVESIQ | AEDESAKLCK | 
    150:
    RRIEHLKEHS | SDQPAAASVW | KRKRMDRMMV | EHLLRCGYYN | TAVKLARQSG | 
    200:
    IEDLVNIEMF | LTAKEVEESL | ERRETATCLA | WCHDNKSRLR | KMKSCLEFSL | 
    250:
    RIQEFIELIR | QNKRLDAVRH | ARKHFSQAEG | SQLDEVRQAM | GMLAFPPDTH | 
    300:
    ISPYKDLLDP | ARWRMLIQQF | RYDNYRLHQL | GNNSVFTLTL | QAGLSAIKTP | 
    350:
    QCYKEDGSSK | SPDCPVCSRS | LNKLAQPLPM | AHCANSRLVC | KISGDVMNEN | 
    396:
    NPPMMLPNGY | VYGYNSLLSI | RQDDKVVCPR | TKEVFHFSQA | EKVYIM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    KEGG:
    MIM:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Macrophage erythroblast attacher
    ELISA Kit for Human Macrophage erythroblast attacher
    ELISA Kit for Human Macrophage erythroblast attacher
    ELISA Kit for Human Macrophage erythroblast attacher
    ELISA Kit for Human Macrophage erythroblast attacher
    CLIA Kit for Human Macrophage erythroblast attacher
    CLIA Kit for Human Macrophage erythroblast attacher
    CLIA Kit for Human Macrophage erythroblast attacher
    CLIA Kit for Human Macrophage erythroblast attacher
    CLIA Kit for Human Macrophage erythroblast attacher
    Polyclonal Antibody for Human Macrophage erythroblast attacher
    Polyclonal Antibody for Human Macrophage erythroblast attacher
    Polyclonal Antibody for Human Macrophage erythroblast attacher
    Polyclonal Antibody for Human Macrophage erythroblast attacher
    Polyclonal Antibody for Human Macrophage erythroblast attacher
    Monoclonal Antibody for Human Macrophage erythroblast attacher
    Monoclonal Antibody for Human Macrophage erythroblast attacher
    Monoclonal Antibody for Human Macrophage erythroblast attacher
    Monoclonal Antibody for Human Macrophage erythroblast attacher
    Monoclonal Antibody for Human Macrophage erythroblast attacher
    Protein for Human Macrophage erythroblast attacher
    Protein for Human Macrophage erythroblast attacher
    Protein for Human Macrophage erythroblast attacher
    Protein for Human Macrophage erythroblast attacher
    Protein for Human Macrophage erythroblast attacher

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    References
    1. 1.
      "Identification of a human cell proliferation gene 5."
      Kim J.W.
      Submitted (2003-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4)
      tissue: Embryo.
      tissue: Thymus.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
    4. 4.
      "Molecular identification and functional characterization of a novel protein that mediates the attachment of erythroblasts to macrophages."
      Hanspal M. , Smockova Y. , Uong Q.
      Blood92:2940-2950(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-396 (ISOFORM 2);REGION;FUNCTION;TISSUE SPECIFICITY
    5. 5.
      "Identification of new human cancer-related gene (HLC-10)."
      Kim J.W.
      Submitted (2002-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-396 (ISOFORM 1)
    6. 6.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-396 (ISOFORM 1)
    7. 7.
      "Emp is a component of the nuclear matrix of mammalian cells and undergoes dynamic rearrangements during cell division."
      Bala S. , Kumar A. , Soni S. , Sinha S. , Hanspal M.
      Biochem. Biophys. Res. Commun.342:1040-1048(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBUNIT;DEVELOPMENTAL STAGE;SUBCELLULAR LOCATION
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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