MAPKAPK3 ELISA Kit for Human(Homo sapiens) | EIAab.comMAPKAPK3 ELISA Kit for Human(Homo sapiens)

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MAPKAPK3 (Gene name),

MAP kinase-activated protein kinase 3 (Protein name ), MAPK3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MAPKAPK3;

Protein name:

MAP kinase-activated protein kinase 3(MAPK-activated protein kinase 3;MAPKAP kinase 3;MAPKAPK-3);

Alternative:

Chromosome 3p kinase(3pK);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with TCF3 and with polycomb proteins, such as PCH2 and BMI1/PCGF4.

Function:

Modulator of polycomb-mediated repression, which can be activated either by ERK, p38 and JNK. Substrate of CSBP. In vitro, phosphorylates HSPB1, BMI1/PCGF4 and TCF3.

Subcellular Location:

Nucleus Cytoplasm Predominantly located in the nucleus, when activated it translocates to the cytoplasm.

Protein Attributes:

Sequence length:

382

Sequence:

50:

100:

150:

200:

250:

300:

350:

382:

IKDLKTSNNR | LLNKRRKKQA | GSSSASQGCN | NQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q16644

MIM:

602130

STRING:

9606.ENSP00000350639

UniGene:

Hs.234521

KEGG:

hsa:7867

String:

Q16644

Pfam:

PF00069

Uniprot:

Q16644

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ELISA Kit for Human MAPK-activated protein kinase 3

Cat.:

E1632r

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96T

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ELISA Kit for Human MAPK-activated protein kinase 3

Cat.:

E1632h

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96T

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ELISA Kit for Human MAPK-activated protein kinase 3

Cat.:

E1632b

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96T

ELISA Kit for Human MAPK-activated protein kinase 3

Cat.:

E1632m

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96T

CLIA Kit for Human MAPK-activated protein kinase 3

Cat.:

U1632m

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96T

CLIA Kit for Human MAPK-activated protein kinase 3

Cat.:

U1632b

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96T

CLIA Kit for Human MAPK-activated protein kinase 3

Cat.:

U1632h

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MSDS:

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Packing:

96T

CLIA Kit for Human MAPK-activated protein kinase 3

Cat.:

U1632r

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96T

Polyclonal Antibody for Human MAPK-activated protein kinase 3

Cat.:

P1632Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human MAPK-activated protein kinase 3

Cat.:

P1632Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human MAPK-activated protein kinase 3

Cat.:

P1632Rb-m

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40ug/0.2ml

Monoclonal Antibody for Human MAPK-activated protein kinase 3

Protein for Human MAPK-activated protein kinase 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase."
McLaughlin M.M. , Kumar S. , McDonnell P.C. , Van Horn S. , Lee J.C. , Livi G.P. , Young P.R.
J. Biol. Chem.271:8488-8492(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;PHOSPHORYLATION
2.

"3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region."
Sithanandam G. , Latif F. , Duh F.-M. , Bernal R. , Smola U. , Li H. , Kuzmin I. , Wixler V. , Geil L. , Shrestha S. , Lloyd P.A. , Bader S. , Sekido Y. , Tartof K.D. , Kashuba V.I. , Zabarovsky E.R. , Dean M. , Klein G. , more...
Mol. Cell. Biol.16:868-876(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;PHOSPHORYLATION BY MAPK1/ERK2 AND MAPK3/ERK1
tissue: Heart.
3.

Sithanandam G. , Latif F. , Duh F.-M. , Bernal R. , Smola U. , Li H. , Kuzmin I. , Wixler V. , Geil L. , Shrestha S. , Lloyd P.A. , Bader S. , Sekido Y. , Tartof K.D. , Kashuba V.I. , Zabarovsky E.R. , Dean M. , Klein G. , more...
Mol. Cell. Biol.16:1880-1880(1996)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
4.

"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Goshima N. , Kawamura Y. , Fukumoto A. , Miura A. , Honma R. , Satoh R. , Wakamatsu A. , Yamamoto J. , Kimura K. , Nishikawa T. , Andoh T. , Iida Y. , Ishikawa K. , Ito E. , Kagawa N. , Kaminaga C. , Kanehori K. , Kawakami B. , more...
Nat. Methods5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Colon.
tissue: Skin.
7.

"A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress."
Clifton A.D. , Young P.R. , Cohen P.
FEBS Lett.392:209-214(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;FUNCTION IN PHOSPHORYLATION OF HSPB1
8.

"Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation."
Rogalla T. , Ehrnsperger M. , Preville X. , Kotlyarov A. , Lutsch G. , Ducasse C. , Paul C. , Wieske M. , Arrigo A.P. , Buchner J. , Gaestel M.
J. Biol. Chem.274:18947-18956(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF HSPB1
9.

"Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity."
Neufeld B. , Grosse-Wilde A. , Hoffmeyer A. , Jordan B.W. , Chen P. , Dinev D. , Ludwig S. , Rapp U.R.
J. Biol. Chem.275:20239-20242(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TCF3
10.

"Mitogen-activated 3p kinase is active in the nucleus."
Zakowski V. , Keramas G. , Kilian K. , Rapp U.R. , Ludwig S.
Exp. Cell Res.299:101-109(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
11.

"MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1."
Voncken J.W. , Niessen H. , Neufeld B. , Rennefahrt U. , Dahlmans V. , Kubben N. , Holzer B. , Ludwig S. , Rapp U.R.
J. Biol. Chem.280:5178-5187(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF LYS-73;INTERACTION WITH PHC2 AND BMI1
12.

"Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex."
Mendoza H. , Campbell D.G. , Burness K. , Hastie J. , Ronkina N. , Shim J.H. , Arthur J.S. , Davis R.J. , Gaestel M. , Johnson G.L. , Ghosh S. , Cohen P.
Biochem. J.409:711-722(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF TAB3
13.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin."
Ronkina N. , Menon M.B. , Schwermann J. , Tiedje C. , Hitti E. , Kotlyarov A. , Gaestel M.
Biochem. Pharmacol.80:1915-1920(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"MK2 and MK3--a pair of isoenzymes?"
Ronkina N. , Kotlyarov A. , Gaestel M.
Front. Biosci.13:5511-5521(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
16.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"High-resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand."
Cheng R. , Felicetti B. , Palan S. , Toogood-Johnson I. , Scheich C. , Barker J. , Whittaker M. , Hesterkamp T.
Protein Sci.19:168-173(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 33-349 IN COMPLEX WITH INHIBITOR P4O
19.

"Structure-based lead identification of ATP-competitive MK2 inhibitors."
Barf T. , Kaptein A. , de Wilde S. , van der Heijden R. , van Someren R. , Demont D. , Schultz-Fademrecht C. , Versteegh J. , van Zeeland M. , Seegers N. , Kazemier B. , van de Kar B. , van Hoek M. , de Roos J. , Klop H. , Smeets R. , Hofstra C. , Hornberg J. , more...
Bioorg. Med. Chem. Lett.21:3818-3822(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.09 ANGSTROMS) OF 33-349 IN COMPLEX WITH INHIBITOR 5B
20.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-28; ALA-105 AND TYR-276

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