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Index > Protein center > Marcks(Gene name) > Mouse
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  • Marcks (Gene name),
  • Myristoylated alanine-rich C-kinase substrate (Protein name ),  MARCS_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Marcks(Macs);
    Protein name:
    Myristoylated alanine-rich C-kinase substrate(MARCKS);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
    Subcellular Location:
    Cytoplasm cytoskeleton Membrane Lipid-anchor
    Protein Attributes:
    Sequence length:
    309
    Sequence:
    50:
    MGAQFSKTAA | KGEATAERPG | EAAVASSPSK | ANGQENGHVK | VNGDASPAAA | 
    100:
    EPGAKEELQA | NGSAPAADKE | EPASGSAATP | AAAEKDEAAA | ATEPGAGAAD | 
    150:
    KEAAEAEPAE | PSSPAAEAEG | ASASSTSSPK | AEDGAAPSPS | SETPKKKKKR | 
    200:
    FSFKKSFKLS | GFSFKKSKKE | SGEGAEAEGA | TAEGAKDEAA | AAAGGEGAAA | 
    250:
    PGEQAGGAGA | EGAAGGEPRE | AEAAEPEQPE | QPEQPAAEEP | QAEEQSEAAG | 
    300:
    EKAEEPAPGA | TAGDASSAAG | PEQEAPAATD | EAAASAAPAA | SPEPQPECSP | 
    309:
    EAPPAPTAE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse MARCKS
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    E15218m
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    ELISA Kit for Mouse MARCKS
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    E15218c
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    Packing:
    96T
    ELISA Kit for Mouse MARCKS
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    E15218h
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    ELISA Kit for Mouse MARCKS
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    E15218b
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    ELISA Kit for Mouse MARCKS
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    E15218r
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    96T
    CLIA Kit for Mouse MARCKS
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    U15218m
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    96T
    CLIA Kit for Mouse MARCKS
    Cat.:
    U15218b
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    Packing:
    96T
    CLIA Kit for Mouse MARCKS
    Cat.:
    U15218h
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    96T
    CLIA Kit for Mouse MARCKS
    Cat.:
    U15218r
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    Packing:
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    CLIA Kit for Mouse MARCKS
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    U15218c
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    96T
    Polyclonal Antibody for Mouse MARCKS
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    P15218Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse MARCKS
    Polyclonal Antibody for Mouse MARCKS
    Polyclonal Antibody for Mouse MARCKS
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    P15218Rb-m
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    Packing:
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    Polyclonal Antibody for Mouse MARCKS
    Cat.:
    P15218Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse MARCKS
    Monoclonal Antibody for Mouse MARCKS
    Monoclonal Antibody for Mouse MARCKS
    Monoclonal Antibody for Mouse MARCKS
    Monoclonal Antibody for Mouse MARCKS
    Protein for Mouse MARCKS
    Protein for Mouse MARCKS
    Protein for Mouse MARCKS
    Protein for Mouse MARCKS
    Protein for Mouse MARCKS

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    Linearity
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    References
    1. 1.
      "Cloning and molecular characterization of the murine macrophage '68-kDa' protein kinase C substrate and its regulation by bacterial lipopolysaccharide."
      Seykora J.T. , Ravetch J.V. , Aderem A.
      Proc. Natl. Acad. Sci. U.S.A.88:2505-2509(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Macrophage.
    2. 2.
      "Protein kinase C activation potently down-regulates the expression of its major substrate, 80K, in Swiss 3T3 cells."
      Brooks S.F. , Herget T. , Erusalimsky J.D. , Rozengurt E.
      EMBO J.10:2497-2505(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
      tissue: Fibroblast.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Olfactory epithelium.
    4. 4.
      Lubec G. , Kang S.U.
      Submitted (2007-04) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 131-145 AND 170-186;IDENTIFICATION BY MASS SPECTROMETRY
      strain: C57BL/6.
      tissue: Brain.
    5. 5.
      "Purification and internal amino acid sequence of the 80 kDa protein kinase C substrate from Swiss 3T3 fibroblasts. Homology with substrates from brain."
      Brooks S.F. , Erusalimsky J.D. , Totty N.F. , Rozengurt E.
      FEBS Lett.268:291-295(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE
      strain: Swiss.
      tissue: Fibroblast.
    6. 6.
      "p42 MAPK phosphorylates 80 kDa MARCKS at Ser-113."
      Schoenwasser D.C. , Palmer R.H. , Herget T. , Parker P.J.
      FEBS Lett.395:1-5(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 102-130;PHOSPHORYLATION AT SER-113;MUTAGENESIS OF SER-113
    7. 7.
      "Relationship between the major protein kinase C substrates acidic 80-kDa protein-kinase-C substrate (80K) and myristoylated alanine-rich C-kinase substrate (MARCKS). Members of a gene family or equivalent genes in different species."
      Herget T. , Brooks S.F. , Broad S. , Rozengurt E.
      Eur. J. Biochem.209:7-14(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 182-301
    8. 8.
      "The myristoylated alanine-rich C-kinase substrate (MARCKS) is sequentially phosphorylated by conventional, novel and atypical isotypes of protein kinase C."
      Herget T. , Oehrlein S.A. , Pappin D.J.C. , Rozengurt E. , Parker P.J.
      Eur. J. Biochem.233:448-457(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-152; SER-156 AND SER-163
    9. 9.
      "Phosphoproteomic analysis of the developing mouse brain."
      Ballif B.A. , Villen J. , Beausoleil S.A. , Schwartz D. , Gygi S.P.
      Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46 AND SER-246;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic brain.
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    11. 11.
      "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
      Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
    12. 12.
      "Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca2+-calmodulin."
      Yamauchi E. , Nakatsu T. , Matsubara M. , Kato H. , Taniguchi H.
      Nat. Struct. Biol.10:226-231(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 148-166 IN COMPLEX WITH CALMODULIN
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