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Index > Protein center > MARCH6(Gene name) > Human
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  • MARCH6 (Gene name),
  • E3 ubiquitin-protein ligase MARCH6 (Protein name ),  MARH6_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MARCH6(KIAA0597;RNF176;TEB4);
    Protein name:
    E3 ubiquitin-protein ligase MARCH6;
    Alternative:
    Membrane-associated RING finger protein 6;Doa10 homolog;Protein TEB-4;Membrane-associated RING-CH protein VI(MARCH-VI);RING finger protein 176;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with DIO2.
    Function:
    E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.
    Subcellular Location:
    Endoplasmic reticulum membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    910
    Sequence:
    50:
    MDTAEEDICR | VCRSEGTPEK | PLYHPCVCTG | SIKFIHQECL | VQWLKHSRKE | 
    100:
    YCELCKHRFA | FTPIYSPDMP | SRLPIQDIFA | GLVTSIGTAI | RYWFHYTLVA | 
    150:
    FAWLGVVPLT | ACRIYKCLFT | GSVSSLLTLP | LDMLSTENLL | ADCLQGCFVV | 
    200:
    TCTLCAFISL | VWLREQIVHG | GAPIWLEHAA | PPFNAAGHHQ | NEAPAGGNGA | 
    250:
    ENVAADQPAN | PPAENAVVGE | NPDAQDDQAE | EEEEDNEEED | DAGVEDAADA | 
    300:
    NNGAQDDMNW | NALEWDRAAE | ELTWERMLGL | DGSLVFLEHV | FWVVSLNTLF | 
    350:
    ILVFAFCPYH | IGHFSLVGLG | FEEHVQASHF | EGLITTIVGY | ILLAITLIIC | 
    400:
    HGLATLVKFH | RSRRLLGVCY | IVVKVSLLVV | VEIGVFPLIC | GWWLDICSLE | 
    450:
    MFDATLKDRE | LSFQSAPGTT | MFLHWLVGMV | YVFYFASFIL | LLREVLRPGV | 
    500:
    LWFLRNLNDP | DFNPVQEMIH | LPIYRHLRRF | ILSVIVFGSI | VLLMLWLPIR | 
    550:
    IIKSVLPNFL | PYNVMLYSDA | PVSELSLELL | LLQVVLPALL | EQGHTRQWLK | 
    600:
    GLVRAWTVTA | GYLLDLHSYL | LGDQEENENS | ANQQVNNNQH | ARNNNAIPVV | 
    650:
    GEGLHAAHQA | ILQQGGPVGF | QPYRRPLNFP | LRIFLLIVFM | CITLLIASLI | 
    700:
    CLTLPVFAGR | WLMSFWTGTA | KIHELYTAAC | GLYVCWLTIR | AVTVMVAWMP | 
    750:
    QGRRVIFQKV | KEWSLMIMKT | LIVAVLLAGV | VPLLLGLLFE | LVIVAPLRVP | 
    800:
    LDQTPLFYPW | QDWALGVLHA | KIIAAITLMG | PQWWLKTVIE | QVYANGIRNI | 
    850:
    DLHYIVRKLA | APVISVLLLS | LCVPYVIASG | VVPLLGVTAE | MQNLVHRRIY | 
    900:
    PFLLMVVVLM | AILSFQVRQF | KRLYEHIKND | KYLVGQRLVN | YERKSGKQGS | 
    910:
    SPPPPQSSQE | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    MIM:
    SMR:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human E3 ubiquitin-protein ligase MARCH6
    ELISA Kit for Human E3 ubiquitin-protein ligase MARCH6
    CLIA Kit for Human E3 ubiquitin-protein ligase MARCH6
    CLIA Kit for Human E3 ubiquitin-protein ligase MARCH6
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase MARCH6
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase MARCH6
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase MARCH6
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase MARCH6
    Protein for Human E3 ubiquitin-protein ligase MARCH6
    Protein for Human E3 ubiquitin-protein ligase MARCH6

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
    3. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Pancreas.
    5. 6.
      "High resolution physical and transcription maps of the Cri-du-chat critical region."
      Simmons A.D. , Lovett M.L.
      Submitted (1997-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 379-910 (ISOFORM 1);VARIANT LEU-622
    6. 7.
      "A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation."
      Swanson R. , Locher M. , Hochstrasser M.
      Genes Dev.15:2660-2674(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION
    7. 8.
      "TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum."
      Hassink G. , Kikkert M. , van Voorden S. , Lee S.-J. , Spaapen R. , van Laar T. , Coleman C.S. , Bartee E. , Frueh K. , Chau V. , Wiertz E.
      Biochem. J.388:647-655(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;UBIQUITINATION;MUTAGENESIS OF CYS-9
    8. 9.
      "Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI)."
      Kreft S.G. , Wang L. , Hochstrasser M.
      J. Biol. Chem.281:4646-4653(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TOPOLOGY
    9. 10.
      "The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase."
      Zavacki A.M. , Arrojo E Drigo R. , Freitas B.C. , Chung M. , Harney J.W. , Egri P. , Wittmann G. , Fekete C. , Gereben B. , Bianco A.C.
      Mol. Cell. Biol.29:5339-5347(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS AN E3 UBIQUITIN LIGASE FOR DIO2;INTERACTION WITH DIO2
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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