Gene name:
MARCH6 (KIAA0597;RNF176;TEB4) ;
Protein name:
E3 ubiquitin-protein ligase MARCH6 ;
Alternative:
Membrane-associated RING finger protein 6 ;Doa10 homolog ;Protein TEB-4 ;Membrane-associated RING-CH protein VI (MARCH-VI) ;RING finger protein 176 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with DIO2.
Function:
E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.
Subcellular Location:
Endoplasmic reticulum membrane
Multi-pass membrane protein
Protein Attributes:
50:
MDTAEEDICR | VCRSEGTPEK | PLYHPCVCTG | SIKFIHQECL | VQWLKHSRKE |
100:
YCELCKHRFA | FTPIYSPDMP | SRLPIQDIFA | GLVTSIGTAI | RYWFHYTLVA |
150:
FAWLGVVPLT | ACRIYKCLFT | GSVSSLLTLP | LDMLSTENLL | ADCLQGCFVV |
200:
TCTLCAFISL | VWLREQIVHG | GAPIWLEHAA | PPFNAAGHHQ | NEAPAGGNGA |
250:
ENVAADQPAN | PPAENAVVGE | NPDAQDDQAE | EEEEDNEEED | DAGVEDAADA |
300:
NNGAQDDMNW | NALEWDRAAE | ELTWERMLGL | DGSLVFLEHV | FWVVSLNTLF |
350:
ILVFAFCPYH | IGHFSLVGLG | FEEHVQASHF | EGLITTIVGY | ILLAITLIIC |
400:
HGLATLVKFH | RSRRLLGVCY | IVVKVSLLVV | VEIGVFPLIC | GWWLDICSLE |
450:
MFDATLKDRE | LSFQSAPGTT | MFLHWLVGMV | YVFYFASFIL | LLREVLRPGV |
500:
LWFLRNLNDP | DFNPVQEMIH | LPIYRHLRRF | ILSVIVFGSI | VLLMLWLPIR |
550:
IIKSVLPNFL | PYNVMLYSDA | PVSELSLELL | LLQVVLPALL | EQGHTRQWLK |
600:
GLVRAWTVTA | GYLLDLHSYL | LGDQEENENS | ANQQVNNNQH | ARNNNAIPVV |
650:
GEGLHAAHQA | ILQQGGPVGF | QPYRRPLNFP | LRIFLLIVFM | CITLLIASLI |
700:
CLTLPVFAGR | WLMSFWTGTA | KIHELYTAAC | GLYVCWLTIR | AVTVMVAWMP |
750:
QGRRVIFQKV | KEWSLMIMKT | LIVAVLLAGV | VPLLLGLLFE | LVIVAPLRVP |
800:
LDQTPLFYPW | QDWALGVLHA | KIIAAITLMG | PQWWLKTVIE | QVYANGIRNI |
850:
DLHYIVRKLA | APVISVLLLS | LCVPYVIASG | VVPLLGVTAE | MQNLVHRRIY |
900:
PFLLMVVVLM | AILSFQVRQF | KRLYEHIKND | KYLVGQRLVN | YERKSGKQGS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human E3 ubiquitin-protein ligase MARCH6
ELISA Kit for Human E3 ubiquitin-protein ligase MARCH6
CLIA Kit for Human E3 ubiquitin-protein ligase MARCH6
CLIA Kit for Human E3 ubiquitin-protein ligase MARCH6
Polyclonal Antibody for Human E3 ubiquitin-protein ligase MARCH6
Polyclonal Antibody for Human E3 ubiquitin-protein ligase MARCH6
Monoclonal Antibody for Human E3 ubiquitin-protein ligase MARCH6
Monoclonal Antibody for Human E3 ubiquitin-protein ligase MARCH6
Protein for Human E3 ubiquitin-protein ligase MARCH6
Protein for Human E3 ubiquitin-protein ligase MARCH6
R&D Technical Data
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Precision
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Recovery
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Linearity
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