Masp1 ELISA Kit for Mouse(Mus musculus) | EIAab.comMasp1 ELISA Kit for Mouse(Mus musculus)

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Masp1 (Gene name),

Mannan-binding lectin serine protease 1 (Protein name ), MASP1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Masp1(Crarf;Masp3);

Protein name:

Mannan-binding lectin serine protease 1;

Alternative:

Complement-activating component of Ra-reactive factor;Complement factor MASP-3;Mannose-binding protein-associated serine protease;Mannose-binding lectin-associated serine protease 1(MASP-1);Serine protease 5;Ra-reactive factor serine protease p100(RaRF);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer. Interacts with the oligomeric lectins MBL1, MBL2, FCN2 and FCN3; triggers the lectin pathway of complement through activation of C3. Interacts with SERPING1.

Function:

Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

704

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

704:

GVRN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P98064

KEGG:

mmu:17174

Pfam:

PF00431

UniGene:

Mm.1213

String:

P98064

Uniprot:

P98064

FOR

ELISA Kit for Mouse Mannan-binding lectin serine protease 1

Cat.:

E1895h

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96T

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ELISA Kit for Mouse Mannan-binding lectin serine protease 1

Cat.:

E1895m

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96T

ELISA Kit for Mouse Mannan-binding lectin serine protease 1

Cat.:

E1895r

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96T

CLIA Kit for Mouse Mannan-binding lectin serine protease 1

Cat.:

U1895r

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Mannan-binding lectin serine protease 1

Cat.:

U1895m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Mannan-binding lectin serine protease 1

Cat.:

U1895h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Mannan-binding lectin serine protease 1

Cat.:

P1895Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Mannan-binding lectin serine protease 1

Cat.:

P1895Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Mannan-binding lectin serine protease 1

Cat.:

P1895Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Mannan-binding lectin serine protease 1

Protein for Mouse Mannan-binding lectin serine protease 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"A 100-kDa protein in the C4-activating component of Ra-reactive factor is a new serine protease having module organization similar to C1r and C1s."
Takayama Y. , Takada F. , Takahashi A. , Kawakami M.
J. Immunol.152:2308-2316(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain: BALB/c.
tissue: Liver.
2.

"Murine serine proteases MASP-1 and MASP-3, components of the lectin pathway activation complex of complement, are encoded by a single structural gene."
Stover C.M. , Lynch N.J. , Dahl M.R. , Hanson S. , Takahashi M. , Frankenberger M. , Ziegler-Heitbrock L. , Eperon I. , Thiel S. , Schwaeble W.J.
Genes Immun.4:374-384(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2);ALTERNATIVE SPLICING (ISOFORM 1)
strain: BALB/c.
tissue: Liver.
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain: C57BL/6J.
tissue: Testis.
4.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
6.

"Presence of a serine protease in the complement-activating component of the complement-dependent bactericidal factor, RaRF, in mouse serum."
Takahashi A. , Takayama Y. , Hatsuse H. , Kawakami M.
Biochem. Biophys. Res. Commun.190:681-687(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 465-704 (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
strain: BALB/c.
tissue: Liver.
7.

"Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway."
Takahashi M. , Iwaki D. , Kanno K. , Ishida Y. , Xiong J. , Matsushita M. , Endo Y. , Miura S. , Ishii N. , Sugamura K. , Fujita T.
J. Immunol.180:6132-6138(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY

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