Gene name:
Masp1 (Crarf;Masp3) ;
Protein name:
Mannan-binding lectin serine protease 1 ;
Alternative:
Complement-activating component of Ra-reactive factor ;Complement factor MASP-3 ;Mannose-binding protein-associated serine protease ;Mannose-binding lectin-associated serine protease 1 (MASP-1) ;Serine protease 5 ;Ra-reactive factor serine protease p100 (RaRF) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homodimer. Interacts with the oligomeric lectins MBL1, MBL2, FCN2 and FCN3; triggers the lectin pathway of complement through activation of C3. Interacts with SERPING1.
Function:
Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.
Subcellular Location:
Secreted
Protein Attributes:
50:
MRFLSFRRLL | LYHVLCLTLT | EVSAHTVELN | EMFGQIQSPG | YPDSYPSDSE |
100:
VTWNITVPEG | FRVQLYFMHF | NLESSYLCEY | DYVKVETEDQ | VLATFCGRET |
150:
TDTEQTPGQE | VVLSPGSFMS | VTFRSDFSNE | ERFTGFDAHY | MAVDVDECKE |
200:
REDEELSCDH | YCHNYIGGYY | CSCRFGYILH | TDNRTCRVEC | SGNLFTQRTG |
250:
TITSPDYPNP | YPKSSECSYT | IDLEEGFMVT | LQFEDIFDIE | DHPEVPCPYD |
300:
YIKIKAGSKV | WGPFCGEKSP | EPISTQSHSI | QILFRSDNSG | ENRGWRLSYR |
350:
AAGNECPKLQ | PPVYGKIEPS | QAVYSFKDQV | LISCDTGYKV | LKDNEVMDTF |
400:
QIECLKDGAW | SNKIPTCKIV | DCGVPAVLKH | GLVTFSTRNN | LTTYKSEIRY |
450:
SCQQPYYKML | HNTTGVYTCS | AHGTWTNEVL | KRSLPTCLPV | CGLPKFSRKH |
500:
ISRIFNGRPA | QKGTTPWIAM | LSQLNGQPFC | GGSLLGSNWV | LTAAHCLHHP |
550:
LDPEEPILHN | SHLLSPSDFK | IIMGKHWRRR | SDEDEQHLHV | KHIMLHPLYN |
600:
PSTFENDLGL | VELSESPRLN | DFVMPVCLPE | HPSTEGTMVI | VSGWGKQFLQ |
650:
RLPENLMEIE | IPIVNYHTCQ | EAYTPLGKKV | TQDMICAGEK | EGGKDACAGD |
700:
SGGPMVTKDA | ERDQWYLVGV | VSWGEDCGKK | DRYGVYSYIY | PNKDWIQRVT |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Rat Mannan-binding lectin serine protease 1
ELISA Kit for Rat Mannan-binding lectin serine protease 1
ELISA Kit for Rat Mannan-binding lectin serine protease 1
CLIA Kit for Rat Mannan-binding lectin serine protease 1
CLIA Kit for Rat Mannan-binding lectin serine protease 1
CLIA Kit for Rat Mannan-binding lectin serine protease 1
Polyclonal Antibody for Rat Mannan-binding lectin serine protease 1
Polyclonal Antibody for Rat Mannan-binding lectin serine protease 1
Polyclonal Antibody for Rat Mannan-binding lectin serine protease 1
Monoclonal Antibody for Rat Mannan-binding lectin serine protease 1
Monoclonal Antibody for Rat Mannan-binding lectin serine protease 1
Monoclonal Antibody for Rat Mannan-binding lectin serine protease 1
Protein for Rat Mannan-binding lectin serine protease 1
Protein for Rat Mannan-binding lectin serine protease 1
Protein for Rat Mannan-binding lectin serine protease 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Murine serine proteases MASP-1 and MASP-3, components of the lectin pathway activation complex of complement, are encoded by a single structural gene."
Stover C.M.
,
Lynch N.J.
,
Dahl M.R.
,
Hanson S.
,
Takahashi M.
,
Frankenberger M.
,
Ziegler-Heitbrock L.
,
Eperon I.
,
Thiel S.
,
Schwaeble W.J.
Genes Immun.4:374-384(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [MRNA] OF 307-461 (ISOFORM 2);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain :
Sprague-Dawley .
tissue :
Liver .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue :
Heart .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 4-704 (ISOFORM 1);GLYCOSYLATION;HOMODIMERIZATION;INTERACTION WITH MBL1
tissue :
Liver .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 12-223 (ISOFORM 1)
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS OF SER-651;AUTOCATALYTIC CLEAVAGE;HOMODIMERIZATION;INTERACTION WITH MBL1
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES