Masp1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comMasp1 ELISA Kit for Rat(Rattus norvegicus)

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Masp1 (Gene name),

Mannan-binding lectin serine protease 1 (Protein name ), MASP1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Masp1(Crarf;Masp3);

Protein name:

Mannan-binding lectin serine protease 1;

Alternative:

Complement-activating component of Ra-reactive factor;Complement factor MASP-3;Mannose-binding protein-associated serine protease;Mannose-binding lectin-associated serine protease 1(MASP-1);Serine protease 5;Ra-reactive factor serine protease p100(RaRF);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homodimer. Interacts with the oligomeric lectins MBL1, MBL2, FCN2 and FCN3; triggers the lectin pathway of complement through activation of C3. Interacts with SERPING1.

Function:

Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

704

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

704:

GVRN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:64023

String:

Q8CHN8

Pfam:

PF00431

UniGene:

Rn.203236

Uniprot:

Q8CHN8

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ELISA Kit for Rat Mannan-binding lectin serine protease 1

Cat.:

E1895h

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96T

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ELISA Kit for Rat Mannan-binding lectin serine protease 1

Cat.:

E1895m

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Packing:

96T

ELISA Kit for Rat Mannan-binding lectin serine protease 1

Cat.:

E1895r

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96T

CLIA Kit for Rat Mannan-binding lectin serine protease 1

Cat.:

U1895r

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MSDS:

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Packing:

96T

CLIA Kit for Rat Mannan-binding lectin serine protease 1

Cat.:

U1895m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat Mannan-binding lectin serine protease 1

Cat.:

U1895h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat Mannan-binding lectin serine protease 1

Cat.:

P1895Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Mannan-binding lectin serine protease 1

Cat.:

P1895Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Mannan-binding lectin serine protease 1

Cat.:

P1895Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat Mannan-binding lectin serine protease 1

Protein for Rat Mannan-binding lectin serine protease 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Murine serine proteases MASP-1 and MASP-3, components of the lectin pathway activation complex of complement, are encoded by a single structural gene."
Stover C.M. , Lynch N.J. , Dahl M.R. , Hanson S. , Takahashi M. , Frankenberger M. , Ziegler-Heitbrock L. , Eperon I. , Thiel S. , Schwaeble W.J.
Genes Immun.4:374-384(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [MRNA] OF 307-461 (ISOFORM 2);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain: Sprague-Dawley.
tissue: Liver.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Heart.
3.

"Interaction of mannose-binding protein with associated serine proteases: effects of naturally occurring mutations."
Wallis R. , Dodd R.B.
J. Biol. Chem.275:30962-30969(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-704 (ISOFORM 1);GLYCOSYLATION;HOMODIMERIZATION;INTERACTION WITH MBL1
tissue: Liver.
4.

"The complement-activating protease P100 is expressed by hepatocytes and is induced by IL-6 in vitro and during the acute phase reaction in vivo."
Knittel T. , Fellmer P. , Neubauer K. , Kawakami M. , Grundmann A. , Ramadori G.
Lab. Invest.77:221-230(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-223 (ISOFORM 1)
5.

"Stoichiometry of complexes between mannose-binding protein and its associated serine proteases. Defining functional units for complement activation."
Chen C.-B. , Wallis R.
J. Biol. Chem.276:25894-25902(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SER-651;AUTOCATALYTIC CLEAVAGE;HOMODIMERIZATION;INTERACTION WITH MBL1
6.

"Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases."
Chen C.-B. , Wallis R.
J. Biol. Chem.279:26058-26065(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES

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