Protein name:
Myb-binding protein 1A ;
Alternative:
PAR-interacting protein (PIP) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Binds to and represses JUN and MYB via the leucine zipper regions present in these proteins. Also binds to and represses PPARGC1A: this interaction is abrogated when PPARGC1A is phosphorylated by MAPK1/ERK. Binds to and stimulates transcription by AHR. Binds to KPNA2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21.
Function:
May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity).
Subcellular Location:
Nucleus
nucleolus
Cytoplasm
Predominantly nucleolar. Also shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1.
Protein Attributes:
50:
MAEMKSPTKA | EPASPAEAPQ | GDRRSLLEHS | REFLDFFWDI | AKPDQETRLR |
100:
ATEKLLEYLR | TRPSDSEMKY | ALKRLITGLG | VGREAARPCY | SLALAQLLQS |
150:
FEDIQLCDIL | GQIQEKYNLQ | AMNKAMMRPT | LFANLFGVLA | LFQSGRLVKD |
200:
KEALMKCVRL | LKILSHHYNH | LQGQPVKALV | DILSEVPESM | FQEILPKVLK |
250:
GDMKVILSSP | KYLELFLLAR | QRVPAELESL | VGSVDLFSED | NIPSLVNILK |
300:
VAANSVKKEQ | KLPDVALNLL | RLALQENKFE | RFWKEVLEEG | LLKKPSYTSS |
350:
YMCFRLLGAS | LPLLSDEQLQ | LVMRGDLIRH | FGEHMVVSKS | QNPLRFIPEI |
400:
SAYVGTFLEG | CQDDPKRQFT | VMVAFTAITN | QGLPVMPTFW | RVTRFLNTEA |
450:
LQNYVTWLRD | MFLQPDLDSL | VDFSTANQKR | VQVASLNVPE | RTVFRLRKWI |
500:
IHRLVSLVDH | LHLEKDEAVV | EQIARFCLFH | AFFKTKKATP | QIPETKQHFS |
550:
FPLEDGNRGV | IVSAFFSLLQ | TLSVKFRQTP | DLAENGKPWT | YRLVQLADML |
600:
LKHNRNVANV | TPLTAQQRQA | WDQMMSTLKE | LEAQSSETRA | IAFQHLLLLV |
650:
GLHLFKSPAE | SCDVLGDIQT | CIKKSMEQNL | RRSRSRAKAS | QEPVWVEVMV |
700:
EILLSLLAQP | SNLMRQVVRS | VFGHVCSHLT | PRGLQLILAV | LNPETNEDEE |
750:
DNVVVTDTDE | KQLKHGEDAD | SDSEDSKNSE | SDVDSEDGEE | SEEEDRDKDV |
800:
DPGFRQQLME | VLQAGNALGG | EEEEEEELGD | EAMMALDQNL | ASLFAEQKMR |
850:
IQARHEEKNK | LQKEKQLRRD | FQIRALDLIE | VLVTKQPEHP | LILELLEPLL |
900:
NIIQRSMRSR | GSTKQEQDLL | HKTARIFMHH | LCRARHYCHE | VEPGAEALHA |
950:
QVERLVQQAG | NQADASVALY | YFNASLYLLR | VLKGNTTKRY | QDGQKLEGAD |
1000:
IKSEPKDSEV | QTTSCLDLDF | VTRVYSASLE | SLLTKRNSPL | TIPMFLDLFS |
1050:
RYPVICKNLL | PIVVQHVAGS | SRPRHQAQAC | LLLQKALSAR | ELRVCFEDPE |
1100:
WEQLISQVLG | KTTQTLQTLG | EAQSKGEHQR | ELSILELLNT | VFRIVNHEKL |
1150:
SVDLTAFLGM | LQGKQQKLQQ | NLQQGNHSSG | SSRLYDLYWQ | AMNLLGVQRP |
1200:
KSEKKNVKDI | PSDSQSPIST | KRKKKGFLPE | TKKRKKLKSE | GTTSEKKAAS |
1250:
QQDAVTEGAM | PAATGKDQPP | STGKKRRKRV | KANTPSQVNG | VTVAKSPAPN |
1300:
NPTLSPSTPP | AKTPKVQKKK | EKLSQVNGST | PVSPVEPESK | KHQKALSTKE |
1344:
VKRRSSQSAL | PKKRARLSLV | SRSPSLLQSG | IRKRRVARRR | VQTP
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Rat Myb-binding protein 1A
ELISA Kit for Rat Myb-binding protein 1A
ELISA Kit for Rat Myb-binding protein 1A
CLIA Kit for Rat Myb-binding protein 1A
CLIA Kit for Rat Myb-binding protein 1A
CLIA Kit for Rat Myb-binding protein 1A
Polyclonal Antibody for Rat Myb-binding protein 1A
Polyclonal Antibody for Rat Myb-binding protein 1A
Polyclonal Antibody for Rat Myb-binding protein 1A
Monoclonal Antibody for Rat Myb-binding protein 1A
Monoclonal Antibody for Rat Myb-binding protein 1A
Monoclonal Antibody for Rat Myb-binding protein 1A
Protein for Rat Myb-binding protein 1A
Protein for Rat Myb-binding protein 1A
Protein for Rat Myb-binding protein 1A
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Nature428:493-521(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Brown Norway .
2.
"Isolation of PIP, a 160 kDa nucleolar protein that interacts with the activation domain of PAR transcription factors."
Comte P.A.
,
Ossipow V.
,
Schibler U.
Submitted (1997-01) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 68-1344