MBL2 ELISA Kit for Human(Homo sapiens) | EIAab.comMBL2 ELISA Kit for Human(Homo sapiens)

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MBL2 (Gene name),

Mannose-binding protein C (Protein name ), MBL2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MBL2(COLEC1;MBL);

Protein name:

Mannose-binding protein C(MBP-C);

Alternative:

MBP1;Collectin-1;Mannose-binding lectin;Mannan-binding protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2. Interacts with MEP1A and MEP1B and may inhibit their catalytic activity.

Function:

Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

248

Sequence:

50:

100:

150:

200:

248:

NRLTYTNWNE | GEPNNAGSDE | DCVLLLKNGQ | WNDVPCSTSH | LAVCEFPI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF01391

MIM:

154545

UniGene:

Hs.499674

KEGG:

hsa:4153

String:

P11226

STRING:

9606.ENSP00000363079

SMR:

P11226

Uniprot:

P11226

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ELISA Kit for Human MBP-C

Cat.:

E1480h

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96T

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ELISA Kit for Human MBP-C

Cat.:

E1480m

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96T

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ELISA Kit for Human MBP-C

Cat.:

E1480p

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96T

ELISA Kit for Human MBP-C

Cat.:

E1480r

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CLIA Kit for Human MBP-C

Cat.:

U1480r

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96T

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CLIA Kit for Human MBP-C

Cat.:

U1480p

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MSDS:

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Packing:

96T

CLIA Kit for Human MBP-C

Cat.:

U1480m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human MBP-C

Cat.:

U1480h

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96T

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Polyclonal Antibody for Human MBP-C

Cat.:

P1480Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MBP-C

Cat.:

P1480Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human MBP-C

Cat.:

P1480Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MBP-C

Monoclonal Antibody for Human MBP-C

Protein for Human MBP-C

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"A human mannose-binding protein is an acute-phase reactant that shares sequence homology with other vertebrate lectins."
Ezekowitz R.A.B. , Day L.E. , Herman G.A.
J. Exp. Med.167:1034-1046(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

Ezekowitz R.A.B. , Day L.E. , Herman G.A.
J. Exp. Med.174:753-753(1991)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
3.

"The human mannose-binding protein gene. Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10."
Sastry K. , Herman G.A. , Day L.E. , Deignan E. , Bruns G. , Morton C.C. , Ezekowitz R.A.B.
J. Exp. Med.170:1175-1189(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SEQUENCE REVISION
tissue: Liver.
4.

"Structure and evolutionary origin of the gene encoding a human serum mannose-binding protein."
Taylor M.E. , Brickell P.M. , Craig R.K. , Summerfield J.A.
Biochem. J.262:763-771(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Different molecular events result in low protein levels of mannan-binding lectin in populations from South-East Africa and South America."
Madsen H.O. , Satz M.L. , Hogh B. , Svejgaard A. , Garred P.
J. Immunol.161:3169-3175(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS CYS-52; ASP-54 AND GLU-57
6.

"Cloning and sequencing of mannan-binding lectin cDNA of Chinese."
Chen Z. , Zhu X. , Xie P.
Mian Yi Xue Za Zhi15:83-86(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ALA-24
tissue: Liver.
7.

"Prokaryotic expression of human mbl."
Wu Z. , Zhang S. , Wang Y.
Submitted (2004-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
8.

"Genetic variation in immune response genes."
Tan J. , Ong R. , Hibberd M.L. , Seielstad M.
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
9.

"Cloning and sequencing of mannan-binding lectin gene from chinese Han people."
Lai Q. , Zuo D. , Chen Z.
Submitted (2008-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
10.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ASP-54
12.

"Restricted polymorphisms of the mannose-binding lectin gene in a population of Papua New Guinea."
Jueliger S. , Kremsner P.G. , Alpers M.P. , Reeder J.C. , Kun J.F.J.
Mutat. Res.505:87-91(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-59;VARIANT ASP-54
13.

"Structure and function of mannan-binding proteins isolated from human liver and serum."
Kurata H. , Sannoh T. , Kozutsumi Y. , Yokota Y. , Kawasaki T.
J. Biochem.115:1148-1154(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-248;SUBCELLULAR LOCATION;HYDROXYLATION AT PRO-47; PRO-73; PRO-79; PRO-82 AND PRO-88
tissue: Liver.
tissue: Plasma.
14.

"A second serine protease associated with mannan-binding lectin that activates complement."
Thiel S. , Vorup-Jensen T. , Stover C.M. , Schwaeble W.J. , Laursen S.B. , Poulsen K. , Willis A.C. , Eggleton P. , Hansen S. , Holmskov U. , Reid K.B.M. , Jensenius J.C.
Nature386:506-510(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MASP1 AND MASP2
15.

"Mannose-binding lectin engagement with late apoptotic and necrotic cells."
Nauta A.J. , Raaschou-Jensen N. , Roos A. , Daha M.R. , Madsen H.O. , Borrias-Essers M.C. , Ryder L.P. , Koch C. , Garred P.
Eur. J. Immunol.33:2853-2863(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
16.

"Nucleic acid is a novel ligand for innate, immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin."
Palaniyar N. , Nadesalingam J. , Clark H. , Shih M.J. , Dodds A.W. , Reid K.B.M.
J. Biol. Chem.279:32728-32736(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING
17.

"Mannan-binding protein blocks the activation of metalloproteases meprin alpha and beta."
Hirano M. , Ma B.Y. , Kawasaki N. , Okimura K. , Baba M. , Nakagawa T. , Miwa K. , Kawasaki N. , Oka S. , Kawasaki T.
J. Immunol.175:3177-3185(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MEP1A AND MEP1B
18.

"Comparative study of the human ficolins reveals unique features of Ficolin-3 (Hakata antigen)."
Hummelshoej T. , Fog L.M. , Madsen H.O. , Sim R.B. , Garred P.
Mol. Immunol.45:1623-1632(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
19.

"Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple alpha-helical coiled-coil."
Sheriff S. , Chang C.Y. , Ezekowitz R.A.
Nat. Struct. Biol.1:789-794(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 108-248;SUBUNIT;COILED-COIL
20.

"Molecular basis of opsonic defect in immunodeficient children."
Sumiya M. , Super M. , Tabona P. , Levinsky R.J. , Arai T. , Turner M.W. , Summerfield J.A.
Lancet337:1569-1570(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASP-54;ASSOCIATION WITH MANNOSE-BINDING PROTEIN DEFICIENCY AND SUSCEPTIBILITY TO CHRONIC INFECTIONS
21.

"High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene."
Lipscombe R.J. , Sumiya M. , Hill A.V.S. , Lau Y.L. , Levinsky R.J. , Summerfield J.A. , Turner M.W.
Hum. Mol. Genet.1:709-715(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASP-54 AND GLU-57;ASSOCIATION WITH MANNOSE-BINDING PROTEIN DEFICIENCY
22.

Lipscombe R.J. , Sumiya M. , Hill A.V.S. , Lau Y.L. , Levinsky R.J. , Summerfield J.A. , Turner M.W.
Hum. Mol. Genet.2:342-342(1993)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
23.

"Distinct and overlapping functions of allelic forms of human mannose binding protein."
Super M. , Gillies S.D. , Foley S. , Sastry K. , Schweinle J.E. , Silverman V.J. , Ezekowitz R.A.
Nat. Genet.2:50-55(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASP-54
24.

"Genotyping of the three major allelic variants of the human mannose-binding lectin gene by denaturing gradient gel electrophoresis."
Gabolde M. , Muralitharan S. , Besmond C.
Hum. Mutat.14:80-83(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-52; ASP-54 AND GLU-57
25.

"Mannose binding lectin genotypes influence recovery from hepatitis B virus infection."
Thio C.L. , Mosbruger T. , Astemborski J. , Greer S. , Kirk G.D. , O'Brien S.J. , Thomas D.L.
J. Virol.79:9192-9196(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO HBV INFECTION;VARIANTS CYS-52; ASP-54 AND GLU-57
26.

"Variant G57E of mannose binding lectin associated with protection against tuberculosis caused by Mycobacterium africanum but not by M. tuberculosis."
Thye T. , Niemann S. , Walter K. , Homolka S. , Intemann C.D. , Chinbuah M.A. , Enimil A. , Gyapong J. , Osei I. , Owusu-Dabo E. , Rusch-Gerdes S. , Horstmann R.D. , Ehlers S. , Meyer C.G.
PLoS ONE6:E20908-E20908(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLU-57;ASSOCIATION WITH PROTECTION AGAINST TUBERCULOSIS

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