MBP ELISA Kit for Human(Homo sapiens) | EIAab.comMBP ELISA Kit for Human(Homo sapiens)

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MBP (Gene name),

Myelin basic protein (Protein name ), MBP_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MBP;

Protein name:

Myelin basic protein(MBP);

Alternative:

Myelin membrane encephalitogenic protein;Myelin A1 protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Isoform 3 exists as a homodimer.

Function:

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

Subcellular Location:

Myelin membrane Peripheral membrane protein Cytoplasmic side Cytoplasmic side of myelin.

Protein Attributes:

Sequence length:

304

Sequence:

50:

100:

150:

200:

250:

300:

304:

MARR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P02686

Pfam:

PF01669

KEGG:

hsa:4155

SMR:

P02686

UniGene:

Hs.551713

MIM:

159430

Uniprot:

P02686

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ELISA Kit for Human MBP

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E0539p

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ELISA Kit for Human MBP

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E0539c

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96T

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ELISA Kit for Human MBP

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E0539m

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ELISA Kit for Human MBP

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E0539h

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ELISA Kit for Human MBP

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E0539r

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ELISA Kit for Human MBP

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ELISA Kit for Human MBP

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E0539b

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96T

CLIA Kit for Human MBP

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U0539p

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96T

CLIA Kit for Human MBP

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U0539m

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96T

CLIA Kit for Human MBP

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U0539h

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96T

CLIA Kit for Human MBP

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U0539r

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CLIA Kit for Human MBP

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U0539b

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CLIA Kit for Human MBP

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CLIA Kit for Human MBP

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U0539c

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Polyclonal Antibody for Human MBP

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P0539Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human MBP

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P0539Rb-h

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Polyclonal Antibody for Human MBP

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P0539Rb-r

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Polyclonal Antibody for Human MBP

Monoclonal Antibody for Human MBP

Protein for Human MBP

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Amino acid sequence of the encephalitogenic basic protein from human myelin."
Carnegie P.R.
Biochem. J.123:57-67(1971) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE (ISOFORM 5)
2.

"Isolation and characterization of a cDNA coding for a novel human 17.3K myelin basic protein (MBP) variant."
Roth H.J. , Kronquist K.E. , Pretorius P.J. , Crandall B.F. , Campagnoni A.T.
J. Neurosci. Res.16:227-238(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6)
tissue: Embryonic spinal cord.
3.

"Identification of three forms of human myelin basic protein by cDNA cloning."
Kamholz J. , de Ferra F. , Puckett C. , Lazzarini R.A.
Proc. Natl. Acad. Sci. U.S.A.83:4962-4966(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 5)
4.

"Evidence for the expression of four myelin basic protein variants in the developing human spinal cord through cDNA cloning."
Roth H.J. , Kronquist K.E. , de Rosbo N. , Crandall B.F. , Campagnoni A.T.
J. Neurosci. Res.17:321-328(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4; 5 AND 6)
tissue: Embryonic spinal cord.
5.

"The organization of the human myelin basic protein gene. Comparison with the mouse gene."
Streicher R. , Stoffel W.
Biol. Chem. Hoppe-Seyler370:503-510(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 3; 4; 5 AND 6)
6.

"The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems."
Pribyl T.M. , Campagnoni C.W. , Kampf K. , Kashima T. , Handley V.W. , McMahon J. , Campagnoni A.T.
Proc. Natl. Acad. Sci. U.S.A.90:10695-10699(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY
tissue: Brain.
7.

"Purification of immunologically active recombinant 21.5 kDa isoform of human myelin basic protein."
Nye S.H. , Pelfrey C.M. , Burkwit J.J. , Voskuhl R.R. , Lenardo M.J. , Mueller J.P.
Mol. Immunol.32:1131-1141(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3);FUNCTION;DIMERIZATION;MUTAGENESIS
8.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6)
9.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Amygdala.
10.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
tissue: Hippocampus.
tissue: Subthalamic nucleus.
11.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
12.

"DNA sequence and analysis of human chromosome 18."
Nusbaum C. , Zody M.C. , Borowsky M.L. , Kamal M. , Kodira C.D. , Taylor T.D. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Abouelleil A. , Allen N.R. , Anderson S. , Bloom T. , Bugalter B. , Butler J. , more...
Nature437:551-555(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
13.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 5 AND 6)
tissue: Brain.
tissue: Lung.
tissue: Skin.
14.

"Repetitive DNA (TGGA)n 5' to the human myelin basic protein gene: a new form of oligonucleotide repetitive sequence showing length polymorphism."
Boylan K.B. , Ayres T.M. , Popko B. , Takahashi N. , Hood L.E. , Prusiner S.B.
Genomics6:16-22(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 135-192
15.

"Analysis of the primary sequence of human myelin basic protein peptides 1-44 and 90-170 by fast atom bombardment mass spectrometry."
Scoble H.A. , Whitaker J.N. , Biemann K.
J. Neurochem.47:614-616(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 135-178 AND 224-304 (ISOFORM 3);IDENTIFICATION BY MASS SPECTROMETRY
16.

"The isolation, characterization, and lipid-aggregating properties of a citrulline containing myelin basic protein."
Wood D.D. , Moscarello M.A.
J. Biol. Chem.264:5121-5127(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 148-304 (ISOFORM 5);CITRULLINATION AT ARG-159; ARG-165; ARG-256; ARG-264; ARG-293 AND ARG-304
tissue: Brain.
17.

"The isolation and characterization of four myelin basic proteins from the unbound fraction during CM52 chromatography."
Boulias C. , Pang H. , Mastronardi F. , Moscarello M.A.
Arch. Biochem. Biophys.322:174-182(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 156-172 AND 302-304;CHARACTERIZATION OF C8
tissue: Brain.
18.

"Amino acid sequence of human myelin basic protein peptide 45-89 as determined by mass spectrometry."
Gibson B.W. , Gilliom R.D. , Whitaker J.N. , Biemann K.
J. Biol. Chem.259:5028-5031(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 179-223 (ISOFORM 5);IDENTIFICATION BY MASS SPECTROMETRY
19.

"Encephalitogenic fragment of myelin basic protein. Amino acid sequence of bovine, rabbit, guinea pig, monkey, and human fragments."
Shapira R. , McKneally S.S. , Chou F. , Kibler R.F.
J. Biol. Chem.246:4630-4640(1971)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 179-222 (ISOFORM 5);SEQUENCE REVISION
20.

"Immunologic properties of the main encephalitogenic peptide from the basic protein of human myelin."
Lennon V.A. , Wilks A.V. , Carnegie P.R.
J. Immunol.105:1223-1230(1970) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 246-269 (ISOFORM 3);ENCEPHALITOGENIC PEPTIDE
21.

"Leukocyte gelatinase B cleavage releases encephalitogens from human myelin basic protein."
Proost P. , Van Damme J. , Opdenakker G.
Biochem. Biophys. Res. Commun.192:1175-1181(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE
tissue: Brain.
22.

"Isolation and partial characterization of methylated arginines from the encephalitogenic basic protein of myelin."
Baldwin G.S. , Carnegie P.R.
Biochem. J.123:69-74(1971) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: METHYLATION AT ARG-241
23.

"Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6."
Enslen H. , Raingeaud J. , Davis R.J.
J. Biol. Chem.273:1741-1748(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY MAPK11; MAPK12 AND MAPK14
24.

"Specific Ser-Pro phosphorylation by the RNA-recognition motif containing kinase KIS."
Maucuer A. , Le Caer J.P. , Manceau V. , Sobel A.
Eur. J. Biochem.267:4456-4464(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-299 BY UMHK1
25.

"PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the JNK MAPK pathway and regulates actin cytoskeletal organisation."
Moore T.M. , Garg R. , Johnson C. , Coptcoat M.J. , Ridley A.J. , Morris J.D.H.
J. Biol. Chem.275:4311-4322(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY TAOK2
26.

"Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells."
Nicke B. , Bastien J. , Khanna S.J. , Warne P.H. , Cowling V. , Cook S.J. , Peters G. , Delpuech O. , Schulze A. , Berns K. , Mullenders J. , Beijersbergen R.L. , Bernards R. , Ganesan T.S. , Downward J. , Hancock D.C.
Mol. Cell20:673-685(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY MINK1
27.

"The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines."
Blanco S. , Klimcakova L. , Vega F.M. , Lazo P.A.
FEBS J.273:2487-2504(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY VRK2
28.

"Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK-and caspase-dependent nuclear localization is a requirement for membrane blebbing."
Zihni C. , Mitsopoulos C. , Tavares I.A. , Baum B. , Ridley A.J. , Morris J.D.
J. Biol. Chem.282:6484-6493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY TAOK2
29.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
30.

"The 21.5-kDa isoform of myelin basic protein has a non-traditional PY-nuclear-localization signal."
Smith G.S. , Seymour L.V. , Boggs J.M. , Harauz G.
Biochem. Biophys. Res. Commun.422:670-675(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION (ISOFORM 3)
31.

"Identification and Characterization of citrulline-modified brain proteins by combining HCD and CID fragmentation."
Jin Z. , Fu Z. , Yang J. , Troncosco J. , Everett A.D. , Van Eyk J.E.
Proteomics13:2682-2691(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CITRULLINATION AT ARG-167; ARG-199; ARG-231; ARG-264; ARG-296 AND ARG-303
32.

"Conformation of a tetradecapeptide epitope of myelin basic protein."
Mendz G.L. , Barden J.A. , Martenson R.E.
Eur. J. Biochem.231:659-666(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 135-148;CLEAVAGE OF INITIATOR METHIONINE (ISOFORMS 3; 4; 5 AND 6);ACETYLATION AT ALA-2 (ISOFORMS 3; 4; 5 AND 6)
33.

"Three-dimensional structure of myelin basic protein. II. Molecular modeling and considerations of predicted structures in multiple sclerosis."
Ridsdale R.A. , Beniac D.R. , Tompkins T.A. , Moscarello M.A. , Harauz G.
J. Biol. Chem.272:4269-4275(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF 135-279 (ISOFORM 5)
34.

"Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins."
Li Y. , Li H. , Martin R. , Mariuzza R.A.
J. Mol. Biol.304:177-188(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 218-237 IN COMPLEX WITH HLA-DRA/HLA-DRB5 HETERODIMER
35.

"Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II."
Li Y. , Li H. , Dimasi N. , McCormick J.K. , Martin R. , Schuck P. , Schlievert P.M. , Mariuzza R.A.
Immunity14:93-104(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 221-233 IN COMPLEX WITH HLA-DRA/HLA-DRB5 HETERODIMER AND STREPTOCOCCUS PYOGENES SPEC PEPTIDE
36.

"Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule."
Li Y. , Huang Y. , Lue J. , Quandt J.A. , Martin R. , Mariuzza R.A.
EMBO J.24:2968-2979(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 221-233 IN COMPLEX WITH HLA-DRA/HLA-DRB5 HETERODIMER AND TRAC

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