Mbp ELISA Kit for Mouse(Mus musculus) | EIAab.comMbp ELISA Kit for Mouse(Mus musculus)

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Mbp (Gene name),

Myelin basic protein (Protein name ), MBP_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Mbp(Shi);

Protein name:

Myelin basic protein(MBP);

Alternative:

Myelin A1 protein;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer.

Function:

The classic group of MBP isoforms (isoform 4-isoform 13) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined to optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function.

Subcellular Location:

Isoform 1 Cytoplasm Nucleus

Protein Attributes:

Sequence length:

250

Sequence:

50:

100:

150:

200:

250:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF01669

SMR:

P04370

String:

P04370

KEGG:

mmu:17196

UniGene:

Mm.252063

Uniprot:

P04370

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ELISA Kit for Mouse MBP

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E0539p

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ELISA Kit for Mouse MBP

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E0539c

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96T

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ELISA Kit for Mouse MBP

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E0539m

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ELISA Kit for Mouse MBP

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E0539h

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ELISA Kit for Mouse MBP

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E0539r

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ELISA Kit for Mouse MBP

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ELISA Kit for Mouse MBP

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E0539b

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96T

CLIA Kit for Mouse MBP

Cat.:

U0539p

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96T

CLIA Kit for Mouse MBP

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U0539m

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96T

CLIA Kit for Mouse MBP

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U0539h

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96T

CLIA Kit for Mouse MBP

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U0539r

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96T

CLIA Kit for Mouse MBP

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U0539b

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CLIA Kit for Mouse MBP

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CLIA Kit for Mouse MBP

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U0539c

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96T

Polyclonal Antibody for Mouse MBP

Cat.:

P0539Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse MBP

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P0539Rb-h

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Polyclonal Antibody for Mouse MBP

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P0539Rb-r

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Polyclonal Antibody for Mouse MBP

Monoclonal Antibody for Mouse MBP

Protein for Mouse MBP

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Cloning and characterization of the myelin basic protein gene from mouse: one gene can encode both 14 kd and 18.5 kd MBPs by alternate use of exons."
Takahashi N. , Roach A. , Teplow D.B. , Prusiner S.B. , Hood L.E.
Cell42:139-148(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"Alternative splicing accounts for the four forms of myelin basic protein."
de Ferra F. , Engh H. , Hudson L. , Kamholz J. , Puckett C. , Molineaux S. , Lazzarini R.A.
Cell43:721-727(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Identification of a cDNA coding for a fifth form of myelin basic protein in mouse."
Newman S. , Kitamura K. , Campagnoni A.T.
Proc. Natl. Acad. Sci. U.S.A.84:886-890(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6 AND 7);NUCLEOTIDE SEQUENCE [MRNA] OF 9-194
strain: C57BL/6J.
tissue: Brain.
4.

"Expression of a novel transcript of the myelin basic protein gene."
Kitamura K. , Newman S.L. , Campagnoni C.W. , Verdi J.M. , Mohandas T. , Handley V.W. , Campagnoni A.T.
J. Neurochem.54:2032-2041(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8)
5.

"A novel transcript overlapping the myelin basic protein gene."
Grima B. , Zelenika D. , Pessac B.
J. Neurochem.59:2318-2323(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain: C57BL/6.
tissue: Bone marrow.
6.

"Structure and developmental regulation of Golli-mbp, a 105-kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain."
Campagnoni A.T. , Pribyl T.M. , Campagnoni C.W. , Kampf K. , Amur-Umarjee S. , Landry C.F. , Handley V.W. , Newman S. , Garbay B. , Kitamura K.
J. Biol. Chem.268:4930-4938(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 3)
strain: C57BL/6.
tissue: Brain.
7.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8)
strain: C57BL/6J.
tissue: Cerebellum.
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9)
tissue: Mammary tumor.
9.

"The promoter elements of the mouse myelin basic protein gene function efficiently in NG108-15 neuronal/glial cells."
Miura M. , Tamura T.A. , Aoyama A. , Mikoshiba K.
Gene75:31-38(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 135-157
10.

Lubec G. , Kang S.U.
Submitted (2007-04) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 146-157; 164-175; 196-205 AND 211-222;IDENTIFICATION BY MASS SPECTROMETRY
strain: C57BL/6.
tissue: Brain.
11.

"Gene organization and transcription of duplicated MBP genes of myelin deficient (shi(mld)) mutant mouse."
Okano H. , Tamura T. , Miura M. , Aoyama A. , Ikenaka K. , Oshimura M. , Mikoshiba K.
EMBO J.7:77-83(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 191-224
12.

"Characterization of mouse myelin basic protein messenger RNAs with a myelin basic protein cDNA clone."
Zeller N.K. , Hunkeler M.J. , Campagnoni A.T. , Sprague J. , Lazzarini R.A.
Proc. Natl. Acad. Sci. U.S.A.81:18-22(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 193-222
13.

"Identification of three forms of human myelin basic protein by cDNA cloning."
Kamholz J. , de Ferra F. , Puckett C. , Lazzarini R.A.
Proc. Natl. Acad. Sci. U.S.A.83:4962-4966(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 6 AND 9)
14.

"Identification of the new isoforms of mouse myelin basic protein: the existence of exon 5a."
Aruga J. , Okano H. , Mikoshiba K.
J. Neurochem.56:1222-1226(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 10 AND 11)
tissue: Spinal cord.
15.

"Novel isoforms of mouse myelin basic protein predominantly expressed in embryonic stage."
Nakajima K. , Ikenaka K. , Kagawa T. , Aruga J. , Nakao J. , Nakahira K. , Shiota C. , Kim S.U. , Mikoshiba K.
J. Neurochem.60:1554-1563(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 12 AND 13)
tissue: Embryonic brain.
16.

"Embryonic expression of the myelin basic protein gene: identification of a promoter region that targets transgene expression to pioneer neurons."
Landry C.F. , Pribyl T.M. , Ellison J.A. , Givogri M.I. , Kampf K. , Campagnoni C.W. , Campagnoni A.T.
J. Neurosci.18:7315-7327(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
17.

"The pathobiology of myelin mutants reveal novel biological functions of the MBP and PLP genes."
Campagnoni A.T. , Skoff R.P.
Brain Pathol.11:74-91(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
18.

"Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol."
Vosseller K. , Hansen K.C. , Chalkley R.J. , Trinidad J.C. , Wells L. , Hart G.W. , Burlingame A.L.
Proteomics5:388-398(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-167 AND THR-229;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135 (ISOFORM 10);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139 (ISOFORM 4);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-122 (ISOFORMS 4 AND 6);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113 (ISOFORM 5);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-96 (ISOFORMS 5 AND 8);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain.
20.

"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-199;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-147 (ISOFORM 10);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-151 (ISOFORM 4);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-125 (ISOFORM 5);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain.
21.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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