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Index > Protein center > MCHR1(Gene name) > Human
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  • MCHR1 (Gene name),
  • Melanin-concentrating hormone receptor 1 (Protein name ),  MCHR1_HUMAN from NCBI database.
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  • Gene name:
    MCHR1(GPR24;SLC1);
    Protein name:
    Melanin-concentrating hormone receptor 1(MCH receptor 1;MCH-R1;MCHR-1);
    Alternative:
    MCH-1R(MCH1R;MCHR);G-protein coupled receptor 24;Somatostatin receptor-like protein;SLC-1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with NCDN.
    Function:
    Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    422
    Sequence:
    50:
    MSVGAMKKGV | GRAVGLGGGS | GCQATEEDPL | PNCGACAPGQ | GGRRWRLPQP | 
    100:
    AWVEGSSARL | WEQATGTGWM | DLEASLLPTG | PNASNTSDGP | DNLTSAGSPP | 
    150:
    RTGSISYINI | IMPSVFGTIC | LLGIIGNSTV | IFAVVKKSKL | HWCNNVPDIF | 
    200:
    IINLSVVDLL | FLLGMPFMIH | QLMGNGVWHF | GETMCTLITA | MDANSQFTST | 
    250:
    YILTAMAIDR | YLATVHPISS | TKFRKPSVAT | LVICLLWALS | FISITPVWLY | 
    300:
    ARLIPFPGGA | VGCGIRLPNP | DTDLYWFTLY | QFFLAFALPF | VVITAAYVRI | 
    350:
    LQRMTSSVAP | ASQRSIRLRT | KRVTRTAIAI | CLVFFVCWAP | YYVLQLTQLS | 
    400:
    ISRPTLTFVY | LYNAAISLGY | ANSCLNPFVY | IVLCETFRKR | LVLSVKPAAQ | 
    422:
    GQLRAVSNAQ | TADEERTESK | GT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    Pfam:
    SMR:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human MCH receptor 1
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    E1146h
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    ELISA Kit for Human MCH receptor 1
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    ELISA Kit for Human MCH receptor 1
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    ELISA Kit for Human MCH receptor 1
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    CLIA Kit for Human MCH receptor 1
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    Packing:
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    CLIA Kit for Human MCH receptor 1
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    CLIA Kit for Human MCH receptor 1
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    U1146m
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    Packing:
    96T
    CLIA Kit for Human MCH receptor 1
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    U1146h
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    Polyclonal Antibody for Human MCH receptor 1
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    P1146Rb-r
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    Packing:
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    Polyclonal Antibody for Human MCH receptor 1
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human MCH receptor 1
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    P1146Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human MCH receptor 1
    Monoclonal Antibody for Human MCH receptor 1
    Monoclonal Antibody for Human MCH receptor 1
    Monoclonal Antibody for Human MCH receptor 1
    Monoclonal Antibody for Human MCH receptor 1
    Protein for Human MCH receptor 1
    Protein for Human MCH receptor 1
    Protein for Human MCH receptor 1
    Protein for Human MCH receptor 1

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    References
    1. 1.
      "Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor."
      Shimomura Y. , Mori M. , Sugo T. , Ishibashi Y. , Abe M. , Kurokawa T. , Onda H. , Nishimura O. , Sumino Y. , Fujino M.
      Biochem. Biophys. Res. Commun.261:622-626(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS MET-25; VAL-28; ASP-32; HIS-210; MET-305; GLN-317; SER-377 AND MET-411;CHARACTERIZATION OF VARIANT ASP-32
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ASP-32
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ASP-32
    5. 5.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      King M.M. , Aronstam R.S. , Sharma S.V.
      Submitted (2004-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ASP-32
      tissue: Brain.
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ASP-32
      tissue: Brain.
    7. 7.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ASP-32
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ASP-32
      tissue: Brain.
    10. 10.
      "Characterization of a human gene related to genes encoding somatostatin receptors."
      Kolakowski L.F. Jr. , Jung B.P. , Nguyen T. , Johnson M.P. , Lynch K.R. , Cheng R. , Heng H.H.Q. , George S.R. , O'Dowd B.F.
      FEBS Lett.398:253-258(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-422
    11. 11.
      "Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1."
      Chambers J. , Ames R.S. , Bergsma D. , Muir A. , Fitzgerald L.R. , Hervieu G. , Dytko G.M. , Foley J.J. , Martin J. , Liu W.S. , Park J. , Ellis C. , Ganguly S. , Konchar S. , Cluderay J. , Leslie R. , Wilson S. , Sarau H.M.
      Nature400:261-265(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      "Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization."
      Francke F. , Ward R.J. , Jenkins L. , Kellett E. , Richter D. , Milligan G. , Baechner D.
      J. Biol. Chem.281:32496-32507(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCDN
    13. 13.
      "Melanin-concentrating hormone receptor mutations and human obesity: functional analysis."
      Gibson W.T. , Pissios P. , Trombly D.J. , Luan J. , Keogh J. , Wareham N.J. , Maratos-Flier E. , O'Rahilly S. , Farooqi I.S.
      Obes. Res.12:743-749(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-250 AND GLN-317;CHARACTERIZATION OF VARIANT GLN-317
    14. 14.
      "Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2."
      Hawes B.E. , Green B. , O'Neill K. , Fried S. , Arreaza M.G. , Qiu P. , Simon J.S.
      Obes. Res.12:1327-1334(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-34;CHARACTERIZATION OF VARIANT ARG-34
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