Protein name:
Induced myeloid leukemia cell differentiation protein Mcl-1 ;
Alternative:
Bcl-2-related protein EAT/mcl1 ;Bcl-2-like protein 3 (Bcl2-L-3) ;mcl1/EAT ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with BAD, BOK, BIK and BFM (By similarity). Interacts with PMAIP1. Isoform 1 interacts with BAX, BAK1, TPT1 and BCL2L11. Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptototic BCL2-related proteins.
Function:
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Subcellular Location:
Membrane
Single-pass membrane protein
Cytoplasm
Mitochondrion
Nucleus
nucleoplasm
Cytoplasmic, associated with mitochondria.
Protein Attributes:
50:
MFGLKRNAVI | GLNLYCGGAG | LGAGSGGATR | PGGRLLATEK | EASARREIGG |
100:
GEAGAVIGGS | AGASPPSTLT | PDSRRVARPP | PIGAEVPDVT | ATPARLLFFA |
150:
PTRRAAPLEE | MEAPAADAIM | SPEEELDGYE | PEPLGKRPAV | LPLLELVGES |
200:
GNNTSTDGSL | PSTPPPAEEE | EDELYRQSLE | IISRYLREQA | TGAKDTKPMG |
250:
RSGATSRKAL | ETLRRVGDGV | QRNHETAFQG | MLRKLDIKNE | DDVKSLSRVM |
300:
IHVFSDGVTN | WGRIVTLISF | GAFVAKHLKT | INQESCIEPL | AESITDVLVR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Dog
Rat
ELISA Kit for Human Induced myeloid leukemia cell differentiation protein Mcl-1
ELISA Kit for Human Induced myeloid leukemia cell differentiation protein Mcl-1
ELISA Kit for Human Induced myeloid leukemia cell differentiation protein Mcl-1
ELISA Kit for Human Induced myeloid leukemia cell differentiation protein Mcl-1
CLIA Kit for Human Induced myeloid leukemia cell differentiation protein Mcl-1
CLIA Kit for Human Induced myeloid leukemia cell differentiation protein Mcl-1
CLIA Kit for Human Induced myeloid leukemia cell differentiation protein Mcl-1
CLIA Kit for Human Induced myeloid leukemia cell differentiation protein Mcl-1
Polyclonal Antibody for Human Induced myeloid leukemia cell differentiation protein Mcl-1
Polyclonal Antibody for Human Induced myeloid leukemia cell differentiation protein Mcl-1
Polyclonal Antibody for Human Induced myeloid leukemia cell differentiation protein Mcl-1
Polyclonal Antibody for Human Induced myeloid leukemia cell differentiation protein Mcl-1
Monoclonal Antibody for Human Induced myeloid leukemia cell differentiation protein Mcl-1
Monoclonal Antibody for Human Induced myeloid leukemia cell differentiation protein Mcl-1
Monoclonal Antibody for Human Induced myeloid leukemia cell differentiation protein Mcl-1
Monoclonal Antibody for Human Induced myeloid leukemia cell differentiation protein Mcl-1
Protein for Human Induced myeloid leukemia cell differentiation protein Mcl-1
Protein for Human Induced myeloid leukemia cell differentiation protein Mcl-1
Protein for Human Induced myeloid leukemia cell differentiation protein Mcl-1
Protein for Human Induced myeloid leukemia cell differentiation protein Mcl-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Thalamus .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Mammary gland .
tissue :
Placenta .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 182-289 (ISOFORM 1);VARIANT VAL-227
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Ewing sarcoma .
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Oncogene23:4818-4827(2004)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF N-TERMINUS OF FRAGMENTS OBTAINED BY CASPASE CLEAVAGE;MUTAGENESIS OF ASP-127 AND ASP-157
14.
"Mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response."
Chao J.-R.
,
Wang J.-M.
,
Lee S.-F.
,
Peng H.-W.
,
Lin Y.-H.
,
Chou C.-H.
,
Li J.-C.
,
Huang H.-M.
,
Chou C.-K.
,
Kuo M.-L.
,
Yen J.J.-Y.
,
Yang-Yen H.-F.
Mol. Cell. Biol.18:4883-4898(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : INDUCTION
15.
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Cited for : INTERACTION WITH TPT1;SUBCELLULAR LOCATION
16.
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Cited for : PHOSPHORYLATION AT SER-121 AND THR-163
17.
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Cited for : INTERACTION WITH BAK;SUBCELLULAR LOCATION
18.
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Cited for : PHOSPHORYLATION AT THR-163;MUTAGENESIS OF SER-162 AND THR-163
19.
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Cited for : UBIQUITINATION;MUTAGENESIS OF LYS-5; LYS-40; LYS-136; LYS-194; LYS-197; LYS-208 AND LYS-234
20.
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Cited for : FUNCTION AS INHIBITOR OF APOPTOSIS;PHOSPHORYLATION AT SER-159 BY GSK3-ALPHA AND GSK3-BETA;UBIQUITINATION;MUTAGENESIS OF SER-159
21.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
22.
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Cited for : SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-162 AND THR-163;MUTAGENESIS OF SER-162
23.
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Cited for : INTERACTION WITH BOP/C22ORF29
24.
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Cited for : X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 151-307 IN COMPLEXES WITH PMAIP1 AND BCL2L11
25.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 172-327 IN COMPLEX WITH BCL2L11
26.
"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome."
Ley T.J.
,
Mardis E.R.
,
Ding L.
,
Fulton B.
,
McLellan M.D.
,
Chen K.
,
Dooling D.
,
Dunford-Shore B.H.
,
McGrath S.
,
Hickenbotham M.
,
Cook L.
,
Abbott R.
,
Larson D.E.
,
Koboldt D.C.
,
Pohl C.
,
Smith S.
,
Hawkins A.
,
Abbott S.
,
Locke D.
,
Hillier L.W.
,
Miner T.
,
Fulton L.
,
Magrini V.
,
Wylie T.
,
Glasscock J.
,
Conyers J.
,
Sander N.
,
Shi X.
,
Osborne J.R.
,
Minx P.
,
Gordon D.
,
Chinwalla A.
,
Zhao Y.
,
Ries R.E.
,
Payton J.E.
,
Westervelt P.
,
Tomasson M.H.
,
Watson M.
,
Baty J.
,
Ivanovich J.
,
Heath S.
,
Shannon W.D.
,
Nagarajan R.
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Walter M.J.
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Link D.C.
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Graubert T.A.
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DiPersio J.F.
,
Wilson R.K.
more...
Nature456:66-72(2008)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : VARIANT [LARGE SCALE ANALYSIS] LEU-231