MCPH1 ELISA Kit for Human(Homo sapiens) | EIAab.comMCPH1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > MCPH1(Gene name) > Human

MCPH1 (Gene name),

Microcephalin (Protein name ), MCPH1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MCPH1;

Protein name:

Microcephalin;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.

Subcellular Location:

Cytoplasm cytoskeleton centrosome

Protein Attributes:

Sequence length:

835

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

835:

SGKKKATVKY | LSEKWVLDSI | TQHKVCAPEN | YLLSQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q8NEM0

Pfam:

PF00533

STRING:

9606.ENSP00000342924

UniGene:

Hs.656769

KEGG:

hsa:79648

MIM:

251200

SMR:

Q8NEM0

Uniprot:

Q8NEM0

FOR

ELISA Kit for Human Microcephalin

CLIA Kit for Human Microcephalin

Polyclonal Antibody for Human Microcephalin

Monoclonal Antibody for Human Microcephalin

Protein for Human Microcephalin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Prostate cancer-related gene 3 (pg3) and biallelic markers thereof."
Barry C. , Chumakov I. , Blumenfeld M.

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS SER-171 AND GLY-392
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 96-835;VARIANTS SER-171; HIS-314 AND GLY-392
tissue: Testis.
3.

"DNA sequence and analysis of human chromosome 8."
Nusbaum C. , Mikkelsen T.S. , Zody M.C. , Asakawa S. , Taudien S. , Garber M. , Kodira C.D. , Schueler M.G. , Shimizu A. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Allen N.R. , Anderson S. , Asakawa T. , more...
Nature439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANTS SER-171; HIS-314 AND GLY-392
tissue: Testis.
5.

Lin S.-Y. , Elledge S.J.
Submitted (2003-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 96-835 (ISOFORM 1);VARIANTS SER-171; HIS-314 AND GLY-392
6.

"Identification of microcephalin, a protein implicated in determining the size of the human brain."
Jackson A.P. , Eastwood H. , Bell S.M. , Toomes C. , Adu J. , Carr I.M. , Roberts E. , Hampshire D.J. , Crow Y.J. , Mighell A.J. , Karbani G. , Jafri H. , Rashid Y. , Mueller R.F. , Markham A.F. , Woods C.G.
Am. J. Hum. Genet.71:136-142(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INVOLVEMENT IN MCPH1
7.

"Mutations in microcephalin cause aberrant regulation of chromosome condensation."
Trimborn M. , Bell S.M. , Felix C. , Rashid Y. , Jafri H. , Griffiths P.D. , Neumann L.M. , Krebs A. , Reis A. , Sperling K. , Neitzel H. , Jackson A.P.
Am. J. Hum. Genet.75:261-266(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INVOLVEMENT IN MCPH1
8.

"Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1."
Xu X. , Lee J. , Stern D.F.
J. Biol. Chem.279:34091-34094(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Microcephalin encodes a centrosomal protein."
Zhong X. , Pfeifer G.P. , Xu X.
Cell Cycle5:457-458(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
10.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation."
Richards M.W. , Leung J.W. , Roe S.M. , Li K. , Chen J. , Bayliss R.
J. Mol. Biol.395:908-915(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 1-95
12.

"Molecular basis for the association of microcephalin (MCPH1) protein with the cell division cycle protein 27 (Cdc27) subunit of the anaphase-promoting complex."
Singh N. , Wiltshire T.D. , Thompson J.R. , Mer G. , Couch F.J.
J. Biol. Chem.287:2854-2862(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 640-835 IN COMPLEX WITH PHOSPHORYLATED CDC27 PEPTIDE
13.

"Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure."
Shao Z. , Li F. , Sy S.M. , Yan W. , Zhang Z. , Gong D. , Wen B. , Huen M.S. , Gong Q. , Wu J. , Shi Y.
J. Struct. Biol.177:459-468(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 639-835 OF MUTANT ALA-761 ALONE AND IN COMPLEX WITH H2FAX PEPTIDE
14.

"Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1."
Singh N. , Basnet H. , Wiltshire T.D. , Mohammad D.H. , Thompson J.R. , Heroux A. , Botuyan M.V. , Yaffe M.B. , Couch F.J. , Rosenfeld M.G. , Mer G.
Proc. Natl. Acad. Sci. U.S.A.109:14381-14386(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 640-835
15.

"The first missense alteration in the MCPH1 gene causes autosomal recessive microcephaly with an extremely mild cellular and clinical phenotype."
Trimborn M. , Richter R. , Sternberg N. , Gavvovidis I. , Schindler D. , Jackson A.P. , Prott E.-C. , Sperling K. , Gillessen-Kaesbach G. , Neitzel H.
Hum. Mutat.26:496-496(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MCPH1 ARG-27
16.

"A common SNP of MCPH1 is associated with cranial volume variation in Chinese population."
Wang J.-K. , Li Y. , Su B.
Hum. Mol. Genet.17:1329-1335(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-314; ALA-761 AND SER-828

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