Protein name:
Malignant T cell-amplified sequence 1 (MCT-1) ;
Alternative:
Multiple copies T-cell malignancies ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts (via PUA domain) with DENR.
Function:
Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when over-expressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines over-expressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3.
Subcellular Location:
Cytoplasm
Nuclear relocalization after DNA damage.
Protein Attributes:
50:
MFKKFDEKEN | VSNCIQLKTS | VIKGIKNQLI | EQFPGIEPWL | NQIMPKKDPV |
100:
KIVRCHEHIE | ILTVNGELLF | FRQREGPFYP | TLRLLHKYPF | ILPHQQVDKG |
150:
AIKFVLSGAN | IMCPGLTSPG | AKLYPAAVDT | IVAIMAEGKQ | HALCVGVMKM |
181:
SAEDIEKVNK | GIGIENIHYL | NDGLWHMKTY | K
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Chicken
Mouse
Rat
ELISA Kit for Human MCT-1
ELISA Kit for Human MCT-1
ELISA Kit for Human MCT-1
ELISA Kit for Human MCT-1
ELISA Kit for Human MCT-1
Polyclonal Antibody for Human MCT-1
Polyclonal Antibody for Human MCT-1
Polyclonal Antibody for Human MCT-1
Polyclonal Antibody for Human MCT-1
Polyclonal Antibody for Human MCT-1
Monoclonal Antibody for Human MCT-1
Monoclonal Antibody for Human MCT-1
Monoclonal Antibody for Human MCT-1
Monoclonal Antibody for Human MCT-1
Monoclonal Antibody for Human MCT-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Chondrosarcoma .
tissue :
Eye .
7.
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Cited for : FUNCTION
8.
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Cited for : FUNCTION;SUBCELLULAR LOCATION;INDUCTION
9.
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Cited for : FUNCTION
10.
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Cited for : FUNCTION
11.
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Cited for : FUNCTION
12.
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Cited for : FUNCTION;SUBCELLULAR LOCATION;DOMAIN PUA;INTERACTION WITH DENR
13.
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Cited for : FUNCTION
14.
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Cited for : FUNCTION;PHOSPHORYLATION AT THR-81 AND SER-118;MUTAGENESIS OF THR-81 AND SER-118
15.
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Cited for : FUNCTION
16.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]