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Index > Protein center > MCTS1(Gene name) > Human
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  • MCTS1 (Gene name),
  • Malignant T cell-amplified sequence 1 (Protein name ),  MCTS1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MCTS1(MCT1);
    Protein name:
    Malignant T cell-amplified sequence 1(MCT-1);
    Alternative:
    Multiple copies T-cell malignancies;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts (via PUA domain) with DENR.
    Function:
    Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when over-expressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines over-expressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3.
    Subcellular Location:
    Cytoplasm Nuclear relocalization after DNA damage.
    Protein Attributes:
    Sequence length:
    181
    Sequence:
    50:
    MFKKFDEKEN | VSNCIQLKTS | VIKGIKNQLI | EQFPGIEPWL | NQIMPKKDPV | 
    100:
    KIVRCHEHIE | ILTVNGELLF | FRQREGPFYP | TLRLLHKYPF | ILPHQQVDKG | 
    150:
    AIKFVLSGAN | IMCPGLTSPG | AKLYPAAVDT | IVAIMAEGKQ | HALCVGVMKM | 
    181:
    SAEDIEKVNK | GIGIENIHYL | NDGLWHMKTY | K
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    KEGG:
    UniGene:
    String:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human MCT-1
    Cat.:
    E15021h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human MCT-1
    MSDS:
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    ELISA Kit for Human MCT-1
    MSDS:
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    ELISA Kit for Human MCT-1
    MSDS:
    Please sign in first.
    ELISA Kit for Human MCT-1
    MSDS:
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    CLIA Kit for Human MCT-1
    MSDS:
    Please sign in first.
    CLIA Kit for Human MCT-1
    Cat.:
    U15021h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MCT-1
    MSDS:
    Please sign in first.
    CLIA Kit for Human MCT-1
    MSDS:
    Please sign in first.
    CLIA Kit for Human MCT-1
    MSDS:
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    Polyclonal Antibody for Human MCT-1
    Polyclonal Antibody for Human MCT-1
    Polyclonal Antibody for Human MCT-1
    Polyclonal Antibody for Human MCT-1
    Polyclonal Antibody for Human MCT-1
    Monoclonal Antibody for Human MCT-1
    Monoclonal Antibody for Human MCT-1
    Monoclonal Antibody for Human MCT-1
    Monoclonal Antibody for Human MCT-1
    Monoclonal Antibody for Human MCT-1
    Protein for Human MCT-1
    Protein for Human MCT-1
    Protein for Human MCT-1
    Protein for Human MCT-1
    Protein for Human MCT-1

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    References
    1. 1.
      "A novel candidate oncogene, MCT-1, is involved in cell cycle progression."
      Prosniak M. , Dierov J. , Okami K. , Tilton B. , Jameson B. , Sawaya B.E. , Gartenhaus R.B.
      Cancer Res.58:4233-4237(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
    2. 2.
      "NovelFam3000 -- uncharacterized human protein domains conserved across model organisms."
      Kemmer D. , Podowski R.M. , Arenillas D. , Lim J. , Hodges E. , Roth P. , Sonnhammer E.L.L. , Hoeoeg C. , Wasserman W.W.
      BMC Genomics7:48-48(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
      tissue: Brain.
    4. 4.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Chondrosarcoma.
      tissue: Eye.
    7. 7.
      "Increased G1 cyclin/cdk activity in cells overexpressing the candidate oncogene, MCT-1."
      Dierov J. , Prosniak M. , Gallia G. , Gartenhaus R.B.
      J. Cell. Biochem.74:544-550(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "Expression and stabilization of the MCT-1 protein by DNA damaging agents."
      Herbert G.B. , Shi B. , Gartenhaus R.B.
      Oncogene20:6777-6783(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INDUCTION
    9. 9.
      "Expression of the candidate MCT-1 oncogene in B- and T-cell lymphoid malignancies."
      Shi B. , Hsu H.-L. , Evens A.M. , Gordon L.I. , Gartenhaus R.B.
      Blood102:297-302(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "MCT-1 oncogene contributes to increased in vivo tumorigenicity of MCF7 cells by promotion of angiogenesis and inhibition of apoptosis."
      Levenson A.S. , Thurn K.E. , Simons L.A. , Veliceasa D. , Jarrett J. , Osipo C. , Jordan V.C. , Volpert O.V. , Satcher R.L. Jr. , Gartenhaus R.B.
      Cancer Res.65:10651-10656(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      "The MCT-1 oncogene product impairs cell cycle checkpoint control and transforms human mammary epithelial cells."
      Hsu H.-L. , Shi B. , Gartenhaus R.B.
      Oncogene24:4956-4964(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      "MCT-1 protein interacts with the cap complex and modulates messenger RNA translational profiles."
      Reinert L.S. , Shi B. , Nandi S. , Mazan-Mamczarz K. , Vitolo M. , Bachman K.E. , He H. , Gartenhaus R.B.
      Cancer Res.66:8994-9001(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;DOMAIN PUA;INTERACTION WITH DENR
    13. 13.
      "MCT-1 oncogene downregulates p53 and destabilizes genome structure in the response to DNA double-strand damage."
      Hsu H.-L. , Choy C.O. , Kasiappan R. , Shih H.-J. , Sawyer J.R. , Shu C.-L. , Chu K.-L. , Chen Y.-R. , Hsu H.-F. , Gartenhaus R.B.
      DNA Repair6:1319-1332(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    14. 14.
      "Phosphorylation of MCT-1 by p44/42 MAPK is required for its stabilization in response to DNA damage."
      Nandi S. , Reinert L.S. , Hachem A. , Mazan-Mamczarz K. , Hagner P. , He H. , Gartenhaus R.B.
      Oncogene26:2283-2289(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT THR-81 AND SER-118;MUTAGENESIS OF THR-81 AND SER-118
    15. 15.
      "Activities of ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling."
      Skabkin M.A. , Skabkina O.V. , Dhote V. , Komar A.A. , Hellen C.U. , Pestova T.V.
      Genes Dev.24:1787-1801(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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