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Index > Protein center > ABCB1(Gene name) > Human
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  • ABCB1 (Gene name),
  • Multidrug resistance protein 1 (Protein name ),  MDR1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    ABCB1(MDR1;PGY1);
    Protein name:
    Multidrug resistance protein 1;
    Alternative:
    P-glycoprotein 1;ATP-binding cassette sub-family B member 1;
    CD:
    CD243;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PSMB8.
    Function:
    Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1280
    Sequence:
    50:
    MDLEGDRNGG | AKKKNFFKLN | NKSEKDKKEK | KPTVSVFSMF | RYSNWLDKLY | 
    100:
    MVVGTLAAII | HGAGLPLMML | VFGEMTDIFA | NAGNLEDLMS | NITNRSDIND | 
    150:
    TGFFMNLEED | MTRYAYYYSG | IGAGVLVAAY | IQVSFWCLAA | GRQIHKIRKQ | 
    200:
    FFHAIMRQEI | GWFDVHDVGE | LNTRLTDDVS | KINEGIGDKI | GMFFQSMATF | 
    250:
    FTGFIVGFTR | GWKLTLVILA | ISPVLGLSAA | VWAKILSSFT | DKELLAYAKA | 
    300:
    GAVAEEVLAA | IRTVIAFGGQ | KKELERYNKN | LEEAKRIGIK | KAITANISIG | 
    350:
    AAFLLIYASY | ALAFWYGTTL | VLSGEYSIGQ | VLTVFFSVLI | GAFSVGQASP | 
    400:
    SIEAFANARG | AAYEIFKIID | NKPSIDSYSK | SGHKPDNIKG | NLEFRNVHFS | 
    450:
    YPSRKEVKIL | KGLNLKVQSG | QTVALVGNSG | CGKSTTVQLM | QRLYDPTEGM | 
    500:
    VSVDGQDIRT | INVRFLREII | GVVSQEPVLF | ATTIAENIRY | GRENVTMDEI | 
    550:
    EKAVKEANAY | DFIMKLPHKF | DTLVGERGAQ | LSGGQKQRIA | IARALVRNPK | 
    600:
    ILLLDEATSA | LDTESEAVVQ | VALDKARKGR | TTIVIAHRLS | TVRNADVIAG | 
    650:
    FDDGVIVEKG | NHDELMKEKG | IYFKLVTMQT | AGNEVELENA | ADESKSEIDA | 
    700:
    LEMSSNDSRS | SLIRKRSTRR | SVRGSQAQDR | KLSTKEALDE | SIPPVSFWRI | 
    750:
    MKLNLTEWPY | FVVGVFCAII | NGGLQPAFAI | IFSKIIGVFT | RIDDPETKRQ | 
    800:
    NSNLFSLLFL | ALGIISFITF | FLQGFTFGKA | GEILTKRLRY | MVFRSMLRQD | 
    850:
    VSWFDDPKNT | TGALTTRLAN | DAAQVKGAIG | SRLAVITQNI | ANLGTGIIIS | 
    900:
    FIYGWQLTLL | LLAIVPIIAI | AGVVEMKMLS | GQALKDKKEL | EGSGKIATEA | 
    950:
    IENFRTVVSL | TQEQKFEHMY | AQSLQVPYRN | SLRKAHIFGI | TFSFTQAMMY | 
    1000:
    FSYAGCFRFG | AYLVAHKLMS | FEDVLLVFSA | VVFGAMAVGQ | VSSFAPDYAK | 
    1050:
    AKISAAHIIM | IIEKTPLIDS | YSTEGLMPNT | LEGNVTFGEV | VFNYPTRPDI | 
    1100:
    PVLQGLSLEV | KKGQTLALVG | SSGCGKSTVV | QLLERFYDPL | AGKVLLDGKE | 
    1150:
    IKRLNVQWLR | AHLGIVSQEP | ILFDCSIAEN | IAYGDNSRVV | SQEEIVRAAK | 
    1200:
    EANIHAFIES | LPNKYSTKVG | DKGTQLSGGQ | KQRIAIARAL | VRQPHILLLD | 
    1250:
    EATSALDTES | EKVVQEALDK | AREGRTCIVI | AHRLSTIQNA | DLIVVFQNGR | 
    1280:
    VKEHGTHQQL | LAQKGIYFSM | VSVQAGTKRQ | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    MIM:
    MIM:
    String:
    KEGG:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Multidrug resistance protein 1
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    ELISA Kit for Human Multidrug resistance protein 1
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    ELISA Kit for Human Multidrug resistance protein 1
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    CLIA Kit for Human Multidrug resistance protein 1
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    CLIA Kit for Human Multidrug resistance protein 1
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    Packing:
    96T
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    CLIA Kit for Human Multidrug resistance protein 1
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    Packing:
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    Polyclonal Antibody for Human Multidrug resistance protein 1
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    P8039Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Multidrug resistance protein 1
    Polyclonal Antibody for Human Multidrug resistance protein 1
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    P8039Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Multidrug resistance protein 1
    Monoclonal Antibody for Human Multidrug resistance protein 1
    Monoclonal Antibody for Human Multidrug resistance protein 1
    Protein for Human Multidrug resistance protein 1
    Protein for Human Multidrug resistance protein 1
    Protein for Human Multidrug resistance protein 1

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    Precision
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    Linearity
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    References
    1. 1.
      "Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells."
      Chen C.-J. , Chin J.E. , Ueda K. , Clark D.P. , Pastan I. , Gottesman M.M. , Roninson I.B.
      Cell47:381-389(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS VAL-185 AND ALA-893
    2. 2.
      "Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins."
      Chen C.-J. , Clark D.P. , Ueda K. , Pastan I. , Gottesman M.M. , Roninson I.B.
      J. Biol. Chem.265:506-514(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ALA-893
    3. 3.
      "Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins."
      Chen G. , Duran G.E. , Steger K.A. , Lacayo N.J. , Jaffrezou J.P. , Dumontet C. , Sikic B.I.
      J. Biol. Chem.272:5974-5982(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS VAL-185 AND ALA-893
    4. 4.
      "Cloning of P-glycoprotein cDNA sequence from breast cancer MCF7 cell line."
      Jiang Y. , Sun Q. , Xie Z. , Liu F. , Xu W. , Wang Y.
      Submitted (2008-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    5. 5.
      NIEHS SNPs program
      Submitted (2005-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LEU-17; ASP-21; ASN-400; LYS-566; CYS-593; VAL-836; ALA-893; ALA-1051; THR-1141 AND ILE-1251
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ASP-21
      tissue: Thalamus.
    7. 7.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "mdr1/P-glycoprotein gene segments analyzed from various human leukemic cell lines exhibiting different multidrug resistance profiles."
      Gekeler V. , Weger S. , Probst H.
      Biochem. Biophys. Res. Commun.169:796-802(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 178-215 AND 800-856
    9. 9.
      "P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance."
      Kioka N. , Tsubota J. , Kakehi Y. , Komano T. , Gottesman M.M. , Pastan I. , Ueda K.
      Biochem. Biophys. Res. Commun.162:224-231(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-23 (ISOFORM 1/2)
    10. 10.
      "ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2."
      Kerb R. , Hoffmeyer S. , Brinkmann U.
      Pharmacogenomics2:51-64(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    11. 11.
      "Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome."
      Begley G.S. , Horvath A.R. , Taylor J.C. , Higgins C.F.
      Mol. Immunol.42:137-141(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PSMB5
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      "Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function."
      Katayama K. , Yamaguchi M. , Noguchi K. , Sugimoto Y.
      Cancer Lett.345:124-131(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPP2R3C
    15. 15.
      "An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene."
      Choi K.H. , Chen C.-J. , Kriegler M. , Roninson I.B.
      Cell53:519-529(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-185
    16. 16.
      "Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors."
      Mickley L.A. , Lee J.-S. , Weng Z. , Zhan Z. , Alvarez M. , Wilson W. , Bates S.E. , Fojo T.
      Blood91:1749-1756(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-893 AND THR-999
    17. 17.
      "A new polymorphism (N21D) in the exon 2 of the human MDR1 gene encoding the P-glycoprotein."
      Decleves X. , Chevillard S. , Charpentier C. , Vielh P. , Laplanche J.-L.
      Hum. Mutat.15:486-486(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASP-21
    18. 18.
      "Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo."
      Hoffmeyer S. , Burk O. , von Richter O. , Arnold H.P. , Brockmoeller J. , Johne A. , Cascorbi I. , Gerloff T. , Roots I. , Eichelbaum M. , Brinkmann U.
      Proc. Natl. Acad. Sci. U.S.A.97:3473-3478(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASP-21; LEU-103 AND ASN-400
    19. 19.
      "Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects."
      Cascorbi I. , Gerloff T. , Johne A. , Meisel C. , Hoffmeyer S. , Schwab M. , Schaeffeler E. , Eichelbaum M. , Brinkmann U. , Roots I.
      Clin. Pharmacol. Ther.69:169-174(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASP-21; ASN-400; ALA-893; THR-893 AND PRO-1107
    20. 20.
      "Polymorphism of MDR1 gene in healthy Japanese subjects: a novel SNP with an amino acid substitution (Glu108Lys)."
      Honda T. , Dan Y. , Koyabu N. , Ieiri I. , Otsubo K. , Higuchi S. , Ohtani H. , Sawada J.
      Drug Metab. Pharmacokinet.17:479-481(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LYS-108
    21. 21.
      "Twelve novel single nucleotide polymorphisms in ABCB1/MDR1 among Japanese patients with ventricular tachycardia who were administered amiodarone."
      Itoda M. , Saito Y. , Komamura K. , Ueno K. , Kamakura S. , Ozawa S. , Sawada J.
      Drug Metab. Pharmacokinet.17:566-571(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ILE-1251
    22. 22.
      "Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population."
      Saito S. , Iida A. , Sekine A. , Miura Y. , Ogawa C. , Kawauchi S. , Higuchi S. , Nakamura Y.
      J. Hum. Genet.47:38-50(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-893 AND THR-893
    23. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-893 AND THR-893;ASSOCIATION WITH SUSCEPTIBILITY TO IBD13
    24. 24.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    25. 25.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-887
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