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Index > Protein center > MED18(Gene name) > Human
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  • MED18 (Gene name),
  • Mediator of RNA polymerase II transcription subunit 18 (Protein name ),  MED18_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MED18;
    Protein name:
    Mediator of RNA polymerase II transcription subunit 18;
    Alternative:
    p28b;Mediator complex subunit 18;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
    Function:
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    208
    Sequence:
    50:
    MEAPPVTMMP | VTGGTINMME | YLLQGSVLDH | SLESLIHRLR | GLCDNMEPET | 
    100:
    FLDHEMVFLL | KGQQASPFVL | RARRSMDRAG | APWHLRYLGQ | PEMGDKNRHA | 
    150:
    LVRNCVDIAT | SENLTDFLME | MGFRMDHEFV | AKGHLFRKGI | MKIMVYKIFR | 
    200:
    ILVPGNTDST | EALSLSYLVE | LSVVAPAGQD | MVSDDMKNFA | EQLKPLVHLE | 
    208:
    KIDPKRLM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    Pfam:
    KEGG:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 18
    ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 18
    ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 18
    CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 18
    CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 18
    CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 18
    Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 18
    Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 18
    Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 18
    Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 18
    Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 18
    Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 18
    Protein for Human Mediator of RNA polymerase II transcription subunit 18
    Protein for Human Mediator of RNA polymerase II transcription subunit 18
    Protein for Human Mediator of RNA polymerase II transcription subunit 18

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Physical and functional connections between human Mediator complex and general transcription machinery."
      Furumoto T. , Malik S. , Hayashi K. , Tanaka A. , Ito M. , Roeder R.G. , Hanaoka F. , Ohkuma Y.
      Submitted (2003-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Lymphoma.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Colon.
    3. 3.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Uterus.
    6. 6.
      "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3."
      Sato S. , Tomomori-Sato C. , Banks C.A.S. , Sorokina I. , Parmely T.J. , Kong S.E. , Jin J. , Cai Y. , Lane W.S. , Brower C.S. , Conaway R.C. , Conaway J.W.
      J. Biol. Chem.278:15123-15127(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MED10 AND MED20
    7. 7.
      "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
      Sato S. , Tomomori-Sato C. , Parmely T.J. , Florens L. , Zybailov B. , Swanson S.K. , Banks C.A.S. , Jin J. , Cai Y. , Washburn M.P. , Conaway J.W. , Conaway R.C.
      Mol. Cell14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX
    8. 8.
      "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
      Zhang X. , Krutchinsky A. , Fukuda A. , Chen W. , Yamamura S. , Chait B.T. , Roeder R.G.
      Mol. Cell19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CCNC; MED1; MED12; MED13; MED17; MED20 AND MED21;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX;ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II
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