Protein name:
Mediator of RNA polymerase II transcription subunit 18 ;
Alternative:
p28b ;Mediator complex subunit 18 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MEAPPVTMMP | VTGGTINMME | YLLQGSVLDH | SLESLIHRLR | GLCDNMEPET |
100:
FLDHEMVFLL | KGQQASPFVL | RARRSMDRAG | APWHLRYLGQ | PEMGDKNRHA |
150:
LVRNCVDIAT | SENLTDFLME | MGFRMDHEFV | AKGHLFRKGI | MKIMVYKIFR |
200:
ILVPGNTDST | EALSLSYLVE | LSVVAPAGQD | MVSDDMKNFA | EQLKPLVHLE |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Mouse
ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 18
ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 18
ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 18
CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 18
CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 18
CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 18
Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 18
Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 18
Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 18
Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 18
Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 18
Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 18
Protein for Human Mediator of RNA polymerase II transcription subunit 18
Protein for Human Mediator of RNA polymerase II transcription subunit 18
Protein for Human Mediator of RNA polymerase II transcription subunit 18
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Lymphoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Colon .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Uterus .
6.
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[
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MED10 AND MED20
7.
"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
Sato S.
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Tomomori-Sato C.
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Parmely T.J.
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Florens L.
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Mol. Cell14:685-691(2004)
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PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CCNC; MED1; MED12; MED13; MED17; MED20 AND MED21;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX;ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II