MED21 ELISA Kit for Human(Homo sapiens) | EIAab.comMED21 ELISA Kit for Human(Homo sapiens) | EIAab.com

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MED21 (Gene name),

Mediator of RNA polymerase II transcription subunit 21 (Protein name ), MED21_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

MED21(SRB7;SURB7);

Protein name:

Mediator of RNA polymerase II transcription subunit 21;

Alternative:

RNA polymerase II holoenzyme component SRB7(RNAPII complex component SRB7;hSrb7);Mediator complex subunit 21;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with PPARG (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with THRA in a ligand-dependent fashion.

Function:

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

144

Sequence:

50:

MADRLTQLQD | AVNSLADQFC | NAIGVLQQCG | PPASFNNIQT | AINKDQPANP |

100:

TEEYAQLFAA | LIARTAKDID | VLIDSLPSEE | STAALQAASL | YKLEEENHEA |

144:

ATCLEDVVYR | GDMLLEKIQS | ALADIAQSQL | KTRSGTHSQS | LPDS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

KEGG:

STRING:

9606.ENSP00000282892

String:

MIM:

Pfam:

SMR:

Uniprot:

FOR

ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 21

ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 21

ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 21

CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 21

CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 21

CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 21

Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 21

Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 21

Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 21

Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 21

Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 21

Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 21

Protein for Human Mediator of RNA polymerase II transcription subunit 21

Protein for Human Mediator of RNA polymerase II transcription subunit 21

Protein for Human Mediator of RNA polymerase II transcription subunit 21

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"A mammalian SRB protein associated with an RNA polymerase II holoenzyme."
Chao D.M. , Gadbois E.L. , Murray P.J. , Anderson S.F. , Sonu M.S. , Parvin J.D. , Young R.A.
Nature380:82-85(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH RNA POLYMERASE II
2.

"A human RNA polymerase II complex associated with SRB and DNA-repair proteins."
Maldonado E. , Shiekhattar R. , Sheldon M. , Cho H. , Drapkin R. , Rickert P. , Lees E. , Anderson C.W. , Linn S. , Reinberg D.
Nature381:86-89(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH RNA POLYMERASE II
tissue: Liver.
3.

Maldonado E. , Shiekhattar R. , Sheldon M. , Cho H. , Drapkin R. , Rickert P. , Lees E. , Anderson C.W. , Linn S. , Reinberg D.
Nature384:384-384(1996)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
4.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain cortex.
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Kidney.
8.

"Transcription activation via enhanced preinitiation complex assembly in a human cell-free system lacking TAFIIs."
Oelgeschlaeger T. , Tao Y. , Kang Y.K. , Roeder R.G.
Mol. Cell1:925-931(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription."
Sun X. , Zhang Y. , Cho H. , Rickert P. , Lees E. , Lane W.S. , Reinberg D.
Mol. Cell2:213-222(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN A FORM OF THE MEDIATOR COMPLEX
10.

"The human homologue of Drosophila TRF-proximal protein is associated with an RNA polymerase II-SRB complex."
Xiao H. , Tao Y. , Roeder R.G.
J. Biol. Chem.274:3937-3940(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNA POLYMERASE II AND MED21
11.

"A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation."
Gu W. , Malik S. , Ito M. , Yuan C.-X. , Fondell J.D. , Zhang X. , Martinez E. , Qin J. , Roeder R.G.
Mol. Cell3:97-108(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE SMCC COMPLEX
12.

Gu W. , Malik S. , Ito M. , Yuan C.-X. , Fondell J.D. , Zhang X. , Martinez E. , Qin J. , Roeder R.G.
Mol. Cell3:541-541(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
13.

"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
Sato S. , Tomomori-Sato C. , Parmely T.J. , Florens L. , Zybailov B. , Swanson S.K. , Banks C.A.S. , Jin J. , Cai Y. , Washburn M.P. , Conaway J.W. , Conaway R.C.
Mol. Cell14:685-691(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX
14.

"hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor."
Nevado J. , Tenbaum S.P. , Aranda A.
Mol. Cell. Endocrinol.222:41-51(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH THRA
15.

"MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
Zhang X. , Krutchinsky A. , Fukuda A. , Chen W. , Yamamura S. , Chait B.T. , Roeder R.G.
Mol. Cell19:89-100(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MED1; MED6; MED12; MED13; MED16; MED17; MED18; MED20; MED24; MED28 AND MED30;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX;ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II

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