Med28 ELISA Kit for Mouse(Mus musculus) | EIAab.comMed28 ELISA Kit for Mouse(Mus musculus)

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Med28 (Gene name),

Mediator of RNA polymerase II transcription subunit 28 (Protein name ), MED28_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Med28(Fksg20);

Protein name:

Mediator of RNA polymerase II transcription subunit 28;

Alternative:

Mediator complex subunit 28;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Forms a ternary complex with NF2/merlin and GRB2. Binds to actin.

Function:

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways.

Subcellular Location:

Nucleus Cytoplasm Membrane May be also cytoplasmic and membrane-associated.

Protein Attributes:

Sequence length:

178

Sequence:

50:

100:

150:

178:

KKPADMPQGS | LAFLEQASAN | IPAPLKQT

3D Structure: