Gene name:
MED4 (HSPC126;ARC36;DRIP36;VDRIP) ;
Protein name:
Mediator of RNA polymerase II transcription subunit 4 ;
Alternative:
Mediator complex subunit 4 ;Activator-recruited cofactor 36 kDa component (ARC36) ;Vitamin D3 receptor-interacting protein complex 36 kDa component (DRIP36) ;TRAP/SMCC/PC2 subunit p36 subunit ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MAASSSGEKE | KERLGGGLGV | AGGNSTRERL | LSALEDLEVL | SRELIEMLAI |
100:
SRNQKLLQAG | EENQVLELLI | HRDGEFQELM | KLALNQGKIH | HEMQVLEKEV |
150:
EKRDSDIQQL | QKQLKEAEQI | LATAVYQAKE | KLKSIEKARK | GAISSEEIIK |
200:
YAHRISASNA | VCAPLTWVPG | DPRRPYPTDL | EMRSGLLGQM | NNPSTNGVNG |
250:
HLPGDALAAG | RLPDVLAPQY | PWQSNDMSMN | MLPPNHSSDF | LLEPPGHNKE |
270:
NEDDVEIMST | DSSSSSSESD |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
Bovine
ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 4
ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 4
ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 4
ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 4
CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 4
CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 4
CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 4
CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 4
Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 4
Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 4
Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 4
Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 4
Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 4
Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 4
Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 4
Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 4
Protein for Human Mediator of RNA polymerase II transcription subunit 4
Protein for Human Mediator of RNA polymerase II transcription subunit 4
Protein for Human Mediator of RNA polymerase II transcription subunit 4
Protein for Human Mediator of RNA polymerase II transcription subunit 4
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 14-27 AND 30-42
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Placenta .
tissue :
Testis .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX;ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
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PubMed ]
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]