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Index > Protein center > MED4(Gene name) > Human
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  • MED4 (Gene name),
  • Mediator of RNA polymerase II transcription subunit 4 (Protein name ),  MED4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MED4(HSPC126;ARC36;DRIP36;VDRIP);
    Protein name:
    Mediator of RNA polymerase II transcription subunit 4;
    Alternative:
    Mediator complex subunit 4;Activator-recruited cofactor 36 kDa component(ARC36);Vitamin D3 receptor-interacting protein complex 36 kDa component(DRIP36);TRAP/SMCC/PC2 subunit p36 subunit;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
    Function:
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    270
    Sequence:
    50:
    MAASSSGEKE | KERLGGGLGV | AGGNSTRERL | LSALEDLEVL | SRELIEMLAI | 
    100:
    SRNQKLLQAG | EENQVLELLI | HRDGEFQELM | KLALNQGKIH | HEMQVLEKEV | 
    150:
    EKRDSDIQQL | QKQLKEAEQI | LATAVYQAKE | KLKSIEKARK | GAISSEEIIK | 
    200:
    YAHRISASNA | VCAPLTWVPG | DPRRPYPTDL | EMRSGLLGQM | NNPSTNGVNG | 
    250:
    HLPGDALAAG | RLPDVLAPQY | PWQSNDMSMN | MLPPNHSSDF | LLEPPGHNKE | 
    270:
    NEDDVEIMST | DSSSSSSESD | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    String:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 4
    ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 4
    ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 4
    ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 4
    CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 4
    CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 4
    CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 4
    CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 4
    Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 4
    Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 4
    Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 4
    Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 4
    Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 4
    Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 4
    Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 4
    Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 4
    Protein for Human Mediator of RNA polymerase II transcription subunit 4
    Protein for Human Mediator of RNA polymerase II transcription subunit 4
    Protein for Human Mediator of RNA polymerase II transcription subunit 4
    Protein for Human Mediator of RNA polymerase II transcription subunit 4

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex."
      Rachez C. , Lemon B.D. , Suldan Z. , Bromleigh V. , Gamble M. , Naeaer A.M. , Erdjument-Bromage H. , Tempst P. , Freedman L.P.
      Nature398:824-828(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs."
      Malik S. , Gu W. , Wu W. , Qin J. , Roeder R.G.
      Mol. Cell5:753-760(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 14-27 AND 30-42
    3. 3.
      "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H. , Ye M. , Wu X.-Y. , Ren S.-X. , Zhao M. , Zhao C.-J. , Fu G. , Shen Y. , Fan H.-Y. , Lu G. , Zhong M. , Xu X.-R. , Han Z.-G. , Zhang J.-W. , Tao J. , Huang Q.-H. , Zhou J. , Hu G.-X. , more...
      Genome Res.10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Umbilical cord blood.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Placenta.
      tissue: Testis.
    5. 5.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
      tissue: Small intestine.
    7. 7.
      "The DNA sequence and analysis of human chromosome 13."
      Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
      Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    9. 9.
      "Composite co-activator ARC mediates chromatin-directed transcriptional activation."
      Naeaer A.M. , Beaurang P.A. , Zhou S. , Abraham S. , Solomon W.B. , Tjian R.
      Nature398:828-832(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN ARC COMPLEX;PROTEIN SEQUENCE OF 81-88; 154-165 AND 173-183
    10. 10.
      "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
      Sato S. , Tomomori-Sato C. , Parmely T.J. , Florens L. , Zybailov B. , Swanson S.K. , Banks C.A.S. , Jin J. , Cai Y. , Washburn M.P. , Conaway J.W. , Conaway R.C.
      Mol. Cell14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX
    11. 11.
      "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
      Zhang X. , Krutchinsky A. , Fukuda A. , Chen W. , Yamamura S. , Chait B.T. , Roeder R.G.
      Mol. Cell19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX;ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
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