Protein name:
Myocyte-specific enhancer factor 2A ;
Alternative:
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Binds DNA as a homo- or heterodimer (By similarity). Dimerizes with MEF2D. Interacts with HDAC7. Interacts with PIAS1; the interaction enhances sumoylation. Interacts with HDAC4, HDAC9 and SLC2A4RG. Interacts (via the N-terminal) with MAPK7; the interaction results in the phosphorylation and transcriptional activity of MEF2A.
Function:
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MGRKKIQITR | IMDERNRQVT | FTKRKFGLMK | KAYELSVLCD | CEIALIIFNS |
100:
SNKLFQYAST | DMDKVLLKYT | EYNEPHESRT | NSDIVEALNK | KEHRGCDSPD |
150:
PDTSYVLTPH | TEEKYKKINE | EFDNMMRNHK | IAPGLPPQNF | SMSVTVPVTS |
200:
PSALSYTNPG | SSLVSPSLAA | SSALADTSML | SPPQATLHRN | VSPGAPQRPP |
250:
STGSAGGMLS | TSDLTVPNGA | GSSPVGNGFV | NSRASPNLIG | TTGANSLGKV |
300:
MPTKSPPPPG | GGSLGMNSRK | PDLRVVIPPS | SKGMMPPLNT | QRISSSQATQ |
350:
PLATPVVSVT | TPSLPPQGLV | YSAMPTAYNT | DYSLTSADLS | ALQGFNSPGM |
400:
LSLGQVSAWQ | QHHLGQAALN | SLVAGGQLSQ | GSNLSINTNQ | NINIKSEPIS |
450:
PPRDRMTPSG | FQQQQQPQPP | PPPPQAPQPQ | PRQEVGRSPV | DSLSSSSSSY |
492:
DGSDREDPRG | DFHSPVVLGR | PPNSEDRESP | SVKRMRMDAW | VT
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Pig
Rat
Human
Bovine
Chicken
Mouse
ELISA Kit for Bovine Myocyte-specific enhancer factor 2A
ELISA Kit for Bovine Myocyte-specific enhancer factor 2A
ELISA Kit for Bovine Myocyte-specific enhancer factor 2A
ELISA Kit for Bovine Myocyte-specific enhancer factor 2A
ELISA Kit for Bovine Myocyte-specific enhancer factor 2A
ELISA Kit for Bovine Myocyte-specific enhancer factor 2A
CLIA Kit for Bovine Myocyte-specific enhancer factor 2A
CLIA Kit for Bovine Myocyte-specific enhancer factor 2A
CLIA Kit for Bovine Myocyte-specific enhancer factor 2A
CLIA Kit for Bovine Myocyte-specific enhancer factor 2A
CLIA Kit for Bovine Myocyte-specific enhancer factor 2A
CLIA Kit for Bovine Myocyte-specific enhancer factor 2A
Polyclonal Antibody for Bovine Myocyte-specific enhancer factor 2A
Polyclonal Antibody for Bovine Myocyte-specific enhancer factor 2A
Polyclonal Antibody for Bovine Myocyte-specific enhancer factor 2A
Polyclonal Antibody for Bovine Myocyte-specific enhancer factor 2A
Polyclonal Antibody for Bovine Myocyte-specific enhancer factor 2A
Polyclonal Antibody for Bovine Myocyte-specific enhancer factor 2A
Monoclonal Antibody for Bovine Myocyte-specific enhancer factor 2A
Monoclonal Antibody for Bovine Myocyte-specific enhancer factor 2A
Monoclonal Antibody for Bovine Myocyte-specific enhancer factor 2A
Monoclonal Antibody for Bovine Myocyte-specific enhancer factor 2A
Monoclonal Antibody for Bovine Myocyte-specific enhancer factor 2A
Monoclonal Antibody for Bovine Myocyte-specific enhancer factor 2A
Protein for Bovine Myocyte-specific enhancer factor 2A
Protein for Bovine Myocyte-specific enhancer factor 2A
Protein for Bovine Myocyte-specific enhancer factor 2A
Protein for Bovine Myocyte-specific enhancer factor 2A
Protein for Bovine Myocyte-specific enhancer factor 2A
Protein for Bovine Myocyte-specific enhancer factor 2A
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Hereford .
tissue :
Thymus .