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Index > Protein center > MEF2A(Gene name) > Human
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  • MEF2A (Gene name),
  • Myocyte-specific enhancer factor 2A (Protein name ),  MEF2A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MEF2A(MEF2);
    Protein name:
    Myocyte-specific enhancer factor 2A;
    Alternative:
    Serum response factor-like protein 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds DNA as a homo- or heterodimer. Dimerizes with MEF2D. Interacts with HDAC7 (By similarity). Interacts with PIAS1; the interaction enhances sumoylation. Interacts with HDAC4, HDAC9 and SLC2A4RG. Interacts (via the N-terminal) with MAPK7; the interaction results in the phosphorylation and transcriptional activity of MEF2A.
    Function:
    Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    507
    Sequence:
    50:
    MGRKKIQITR | IMDERNRQVT | FTKRKFGLMK | KAYELSVLCD | CEIALIIFNS | 
    100:
    SNKLFQYAST | DMDKVLLKYT | EYNEPHESRT | NSDIVEALNK | KEHRGCDSPD | 
    150:
    PDTSYVLTPH | TEEKYKKINE | EFDNMMRNHK | IAPGLPPQNF | SMSVTVPVTS | 
    200:
    PNALSYTNPG | SSLVSPSLAA | SSTLTDSSML | SPPQTTLHRN | VSPGAPQRPP | 
    250:
    STGNAGGMLS | TTDLTVPNGA | GSSPVGNGFV | NSRASPNLIG | ATGANSLGKV | 
    300:
    MPTKSPPPPG | GGNLGMNSRK | PDLRVVIPPS | SKGMMPPLSE | EEELELNTQR | 
    350:
    ISSSQATQPL | ATPVVSVTTP | SLPPQGLVYS | AMPTAYNTDY | SLTSADLSAL | 
    400:
    QGFNSPGMLS | LGQVSAWQQH | HLGQAALSSL | VAGGQLSQGS | NLSINTNQNI | 
    450:
    SIKSEPISPP | RDRMTPSGFQ | QQQQQQQQQQ | PPPPPQPQPQ | PPQPQPRQEM | 
    500:
    GRSPVDSLSS | SSSSYDGSDR | EDPRGDFHSP | IVLGRPPNTE | DRESPSVKRM | 
    507:
    RMDAWVT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    MIM:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Myocyte-specific enhancer factor 2A
    ELISA Kit for Human Myocyte-specific enhancer factor 2A
    ELISA Kit for Human Myocyte-specific enhancer factor 2A
    ELISA Kit for Human Myocyte-specific enhancer factor 2A
    ELISA Kit for Human Myocyte-specific enhancer factor 2A
    ELISA Kit for Human Myocyte-specific enhancer factor 2A
    CLIA Kit for Human Myocyte-specific enhancer factor 2A
    CLIA Kit for Human Myocyte-specific enhancer factor 2A
    CLIA Kit for Human Myocyte-specific enhancer factor 2A
    CLIA Kit for Human Myocyte-specific enhancer factor 2A
    CLIA Kit for Human Myocyte-specific enhancer factor 2A
    CLIA Kit for Human Myocyte-specific enhancer factor 2A
    Polyclonal Antibody for Human Myocyte-specific enhancer factor 2A
    Polyclonal Antibody for Human Myocyte-specific enhancer factor 2A
    Polyclonal Antibody for Human Myocyte-specific enhancer factor 2A
    Polyclonal Antibody for Human Myocyte-specific enhancer factor 2A
    Polyclonal Antibody for Human Myocyte-specific enhancer factor 2A
    Polyclonal Antibody for Human Myocyte-specific enhancer factor 2A
    Monoclonal Antibody for Human Myocyte-specific enhancer factor 2A
    Monoclonal Antibody for Human Myocyte-specific enhancer factor 2A
    Monoclonal Antibody for Human Myocyte-specific enhancer factor 2A
    Monoclonal Antibody for Human Myocyte-specific enhancer factor 2A
    Monoclonal Antibody for Human Myocyte-specific enhancer factor 2A
    Monoclonal Antibody for Human Myocyte-specific enhancer factor 2A
    Protein for Human Myocyte-specific enhancer factor 2A
    Protein for Human Myocyte-specific enhancer factor 2A
    Protein for Human Myocyte-specific enhancer factor 2A
    Protein for Human Myocyte-specific enhancer factor 2A
    Protein for Human Myocyte-specific enhancer factor 2A
    Protein for Human Myocyte-specific enhancer factor 2A

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Human SRF-related proteins: DNA-binding properties and potential regulatory targets."
      Pollock R. , Treisman R.
      Genes Dev.5:2327-2341(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MEF2; RSRFC4 AND RSRFC9);DNA-BINDING;TISSUE SPECIFICITY;DIMERIZATION
      tissue: Placenta.
    2. 2.
      Treisman R.
      Submitted (1993-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RSRFC9);SEQUENCE REVISION
    3. 3.
      "Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors."
      Yu Y.-T. , Breitbart R.E. , Smoot L.B. , Lee Y. , Mahdavi V. , Nadal-Ginard B.
      Genes Dev.6:1783-1798(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MEF2 AND RSRFC9);TISSUE SPECIFICITY
      tissue: Heart.
      tissue: Skeletal muscle.
    4. 4.
      Suzuki E. , Lowry J. , Sonoda G. , Testa J.R. , Walsh K.
      Submitted (1996-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS RSRFC4 AND RSRFC9)
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7)
      tissue: Amygdala.
    6. 6.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno F.R.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6)
      tissue: Brain.
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 8)
      tissue: Pancreas.
      tissue: Uterus.
    8. 9.
      "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1."
      Yang C.-C. , Ornatsky O.I. , McDermott J.C. , Cruz T.F. , Prody C.A.
      Nucleic Acids Res.26:4771-4777(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAPK7;PHOSPHORYLATION
    9. 10.
      "HDAC4 deacetylase associates with and represses the MEF2 transcription factor."
      Miska E.A. , Karlsson C. , Langley E. , Nielsen S.J. , Pines J. , Kouzarides T.
      EMBO J.18:5099-5107(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HDAC4 AND HDAC9
    10. 11.
      "Regulation of the MEF2 family of transcription factors by p38."
      Zhao M. , New L. , Kravchenko V.V. , Kato Y. , Gram H. , di Padova F. , Olson E.N. , Ulevitch R.J. , Han J.-D.
      Mol. Cell. Biol.19:21-30(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-312; THR-319 AND SER-453;FUNCTION;HETERODIMERIZATION;MUTAGENESIS OF THR-312; THR-319; SER-355; SER-453 AND SER-479
    11. 12.
      "Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors."
      Yang S.-H. , Galanis A. , Sharrocks A.D.
      Mol. Cell. Biol.19:4028-4038(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAPK14;PHOSPHORYLATION AT THR-312 AND THR-319;MUTAGENESIS OF ARG-269; LYS-270; LEU-273; VAL-275; ILE-277 AND PRO-278
    12. 13.
      "Big mitogen-activated kinase regulates multiple members of the MEF2 protein family."
      Kato Y. , Zhao M. , Morikawa A. , Sugiyama T. , Chakravortty D. , Koide N. , Yoshida T. , Tapping R.I. , Yang Y. , Yokochi T. , Lee J.D.
      J. Biol. Chem.275:18534-18540(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-312; THR-319 AND SER-355;MUTAGENESIS OF THR-312; THR-319 AND SER-355
    13. 14.
      "Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis."
      Okamoto S. , Li Z. , Ju C. , Scholzke M.N. , Mathews E. , Cui J. , Salvesen G.S. , Bossy-Wetzel E. , Lipton S.A.
      Proc. Natl. Acad. Sci. U.S.A.99:3974-3979(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING AT ASP-176; ASP-213 AND ASP-466;FUNCTION;MUTAGENESIS OF ASP-176 AND ASP-213
    14. 15.
      "Phosphorylation motifs regulating the stability and function of myocyte enhancer factor 2A."
      Cox D.M. , Du M. , Marback M. , Yang E.C.C. , Chan J. , Siu K.W.M. , McDermott J.C.
      J. Biol. Chem.278:15297-15303(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-255; THR-312; THR-319 AND SER-408;IDENTIFICATION BY MASS SPECTROMETRY;MUTAGENESIS OF SER-255
    15. 16.
      "Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis."
      Gong X. , Tang X. , Wiedmann M. , Wang X. , Peng J. , Zheng D. , Blair L.A.C. , Marshall J. , Mao Z.
      Neuron38:33-46(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-408;FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-408
    16. 17.
      "Regulation of the human GLUT4 gene promoter: interaction between a transcriptional activator and myocyte enhancer factor 2A."
      Knight J.B. , Eyster C.A. , Griesel B.A. , Olson A.L.
      Proc. Natl. Acad. Sci. U.S.A.100:14725-14730(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLC2A4RG
    17. 18.
      "Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain."
      Zhu B. , Ramachandran B. , Gulick T.
      J. Biol. Chem.280:28749-28760(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF BETA DOMAIN
    18. 19.
      "Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2."
      Tang X. , Wang X. , Gong X. , Tong M. , Park D. , Xia Z. , Mao Z.
      J. Neurosci.25:4823-4834(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING;PHOSPHORYLATION
    19. 20.
      "SUMO-1 modification of MEF2A regulates its transcriptional activity."
      Riquelme C. , Barthel K.K. , Liu X.
      J. Cell. Mol. Med.10:132-144(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-403;INTERACTION WITH PIAS1;FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-403
    20. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-403;PHOSPHORYLATION AT SER-408;FUNCTION;MUTAGENESIS OF LYS-403 AND SER-408
    21. 22.
      "A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation."
      Shalizi A. , Gaudilliere B. , Yuan Z. , Stegmueller J. , Shirogane T. , Ge Q. , Tan Y. , Schulman B. , Harper J.W. , Bonni A.
      Science311:1012-1017(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-408;FUNCTION
    22. 23.
      "Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development."
      Satoh K. , Ohnishi J. , Sato A. , Takeyama M. , Iemura S. , Natsume T. , Shibuya H.
      Mol. Cell. Biol.27:7623-7630(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-312 BY NLK
    23. 24.
      "Quantitative control of adaptive cardiac hypertrophy by acetyltransferase p300."
      Wei J.Q. , Shehadeh L.A. , Mitrani J.M. , Pessanha M. , Slepak T.I. , Webster K.A. , Bishopric N.H.
      Circulation118:934-946(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION;INVOLVEMENT IN CARDIAC HYPERTROPHY
    24. 25.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98; SER-235 AND SER-255;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30 (ISOFORMS 7 AND 8);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    25. 26.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-249;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    26. 27.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    27. 28.
      "Identification of HZF1 as a novel target gene of the MEF2 transcription factor."
      Liu X. , Jin E.Z. , Zhi J.X. , Li X.Q.
      Mol. Med. Report.4:465-469(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CHROMATIN BINDING
    28. 29.
      "Transcription factor MEF2A mutations in patients with coronary artery disease."
      Bhagavatula M.R.K. , Fan C. , Shen G.-Q. , Cassano J. , Plow E.F. , Topol E.J. , Wang Q.
      Hum. Mol. Genet.13:3181-3188(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SER-263; LEU-279 AND ASP-283;CHARACTERIZATION OF VARIANTS SER-263; LEU-279 AND ASP-283
    29. 30.
      "The Pro279Leu variant in the transcription factor MEF2A is associated with myocardial infarction."
      Gonzalez P. , Garcia-Castro M. , Reguero J.R. , Batalla A. , Ordonez A.G. , Palop R.L. , Lozano I. , Montes M. , Alvarez V. , Coto E.
      J. Med. Genet.43:167-169(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-279;ASSOCIATION WITH SUSCEPTIBILITY TO MYOCARDIAL INFARCTION
    30. 31.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-279;LACK OF ASSOCIATION WITH MYOCARDIAL INFARCTION
    31. 32.
      "Solution structure of the MEF2A-DNA complex: structural basis for the modulation of DNA bending and specificity by MADS-box transcription factors."
      Huang K. , Louis J.M. , Donaldson L. , Lim F.L. , Sharrocks A.D. , Clore G.M.
      EMBO J.19:2615-2628(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 2-86 IN COMPLEX WITH DNA
    32. 33.
      "Crystal structure of MEF2A core bound to DNA at 1.5 A resolution."
      Santelli E. , Richmond T.J.
      J. Mol. Biol.297:437-449(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 2-78 IN COMPLEX WITH DNA;DIMERIZATION
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