Mef2c ELISA Kit for Mouse(Mus musculus) | EIAab.comMef2c ELISA Kit for Mouse(Mus musculus) | EIAab.com

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Mef2c (Gene name),

Myocyte-specific enhancer factor 2C (Protein name ), MEF2C_MOUSE from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

Mef2c;

Protein name:

Myocyte-specific enhancer factor 2C;

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with EP300 in differentiating cells; the interaction acetylates MEF2C leading to increased DNA binding and activation. Interacts with HDAC7 and CARM1 (By similarity). Interacts with HDAC4, HDAC7 AND HDAC9; the interaction WITH HDACs represses transcriptional activity. Interacts with LPIN1. Interacts with MYOCD.

Function:

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. May also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1, isoform 2 and isoform 5 (By similarity). Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

474

Sequence:

50:

MGRKKIQITR | IMDERNRQVT | FTKRKFGLMK | KAYELSVLCD | CEIALIIFNS |

100:

TNKLFQYAST | DMDKVLLKYT | EYNEPHESRT | NSDIVETLRK | KGLNGCDSPD |

150:

PDADDSVGHS | PESEDKYRKI | NEDIDLMISR | QRLCAVPPPS | FEMPVTIPVS |

200:

SHNSLVYSNP | VSTLGNPNLL | PLAHPSLQRN | SMSPGVTHRP | PSAGNTGGLM |

250:

GGDLTSGAGT | SAGNGYGNPR | NSPGLLVSPG | NLNKNIQAKS | PPPMNLGMNN |

300:

RKPDLRVLIP | PGSKNTMPSV | SEDVDLLLNQ | RINNSQSAQS | LATPVVSVAT |

350:

PTLPGQGMGG | YPSAISTTYG | TEYSLSSADL | SSLSGFNTAS | ALHLGSVTGW |

400:

QQQHLHNMPP | SALSQLGACT | STHLSQSSNL | SLPSTQSLSI | KSEPVSPPRD |

450:

RTTTPSRYPQ | HTTRHEAGRS | PVDSLSSCSS | SYDGSDREDH | RNEFHSPIGL |

474:

TRPSPDERES | PSVKRMRLSE | GWAT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

UniGene:

Pfam:

SMR:

String:

Uniprot:

FOR

ELISA Kit for Mouse Myocyte-specific enhancer factor 2C

ELISA Kit for Mouse Myocyte-specific enhancer factor 2C

ELISA Kit for Mouse Myocyte-specific enhancer factor 2C

ELISA Kit for Mouse Myocyte-specific enhancer factor 2C

CLIA Kit for Mouse Myocyte-specific enhancer factor 2C

CLIA Kit for Mouse Myocyte-specific enhancer factor 2C

CLIA Kit for Mouse Myocyte-specific enhancer factor 2C

CLIA Kit for Mouse Myocyte-specific enhancer factor 2C

Polyclonal Antibody for Mouse Myocyte-specific enhancer factor 2C

Polyclonal Antibody for Mouse Myocyte-specific enhancer factor 2C

Polyclonal Antibody for Mouse Myocyte-specific enhancer factor 2C

Polyclonal Antibody for Mouse Myocyte-specific enhancer factor 2C

Monoclonal Antibody for Mouse Myocyte-specific enhancer factor 2C

Monoclonal Antibody for Mouse Myocyte-specific enhancer factor 2C

Monoclonal Antibody for Mouse Myocyte-specific enhancer factor 2C

Monoclonal Antibody for Mouse Myocyte-specific enhancer factor 2C

Protein for Mouse Myocyte-specific enhancer factor 2C

Protein for Mouse Myocyte-specific enhancer factor 2C

Protein for Mouse Myocyte-specific enhancer factor 2C

Protein for Mouse Myocyte-specific enhancer factor 2C

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors."
Martin J.F. , Schwarz J.J. , Olson E.N.
Proc. Natl. Acad. Sci. U.S.A.90:5282-5286(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
strain: C57BL/6J.
tissue: Tongue.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5)
tissue: Eye.
4.

"The expression of MEF2 genes is implicated in CNS neuronal differentiation."
Lin X. , Shah S. , Bulleit R.F.
Brain Res. Mol. Brain Res.42:307-316(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
5.

"Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity."
Molkentin J.D. , Li L. , Olson E.N.
J. Biol. Chem.271:17199-17204(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-59;MUTAGENESIS OF SER-59
6.

"Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C."
Lin Q. , Schwarz J. , Bucana C. , Olson E.N.
Science276:1404-1407(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"Requirement of the MADS-box transcription factor MEF2C for vascular development."
Lin Q. , Lu J. , Yanagisawa H. , Webb R. , Lyons G.E. , Richardson J.A. , Olson E.N.
Development125:4565-4574(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE
8.

"A dynamic role for HDAC7 in MEF2-mediated muscle differentiation."
Dressel U. , Bailey P.J. , Wang S.-C.M. , Downes M. , Evans R.M. , Muscat G.E.O.
J. Biol. Chem.276:17007-17013(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HDAC7
9.

"The coactivator-associated arginine methyltransferase is necessary for muscle differentiation: CARM1 coactivates myocyte enhancer factor-2."
Chen S.L. , Loffler K.A. , Chen D. , Stallcup M.R. , Muscat G.E.
J. Biol. Chem.277:4324-4333(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CARM1
10.

"Phosphorylation and alternative pre-mRNA splicing converge to regulate myocyte enhancer factor 2C activity."
Zhu B. , Gulick T.
Mol. Cell. Biol.24:8264-8275(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY OF ISOFORMS
11.

"Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain."
Zhu B. , Ramachandran B. , Gulick T.
J. Biol. Chem.280:28749-28760(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY OF ISOFORMS
12.

"Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR."
Creemers E.E. , Sutherland L.B. , Oh J. , Barbosa A.C. , Olson E.N.
Mol. Cell23:83-96(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYOCD
13.

"Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation."
Wilker P.R. , Kohyama M. , Sandau M.M. , Albring J.C. , Nakagawa O. , Schwarz J.J. , Murphy K.M.
Nat. Immunol.9:603-612(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
14.

"Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cells."
Angelelli C. , Magli A. , Ferrari D. , Ganassi M. , Matafora V. , Parise F. , Razzini G. , Bachi A. , Ferrari S. , Molinari S.
Nucleic Acids Res.36:915-928(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-4;DNA-BINDING;IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;MUTAGENESIS OF ARG-3 AND LYS-4
15.

"MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function."
Barbosa A.C. , Kim M.S. , Ertunc M. , Adachi M. , Nelson E.D. , McAnally J. , Richardson J.A. , Kavalali E.T. , Monteggia L.M. , Bassel-Duby R. , Olson E.N.
Proc. Natl. Acad. Sci. U.S.A.105:9391-9396(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY
16.

"Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo."
Li H. , Radford J.C. , Ragusa M.J. , Shea K.L. , McKercher S.R. , Zaremba J.D. , Soussou W. , Nie Z. , Kang Y.J. , Nakanishi N. , Okamoto S. , Roberts A.J. , Schwarz J.J. , Lipton S.A.
Proc. Natl. Acad. Sci. U.S.A.105:9397-9402(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
17.

"Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis."
Gekas C. , Rhodes K.E. , Gereige L.M. , Helgadottir H. , Ferrari R. , Kurdistani S.K. , Montecino-Rodriguez E. , Bassel-Duby R. , Olson E. , Krivtsov A.V. , Armstrong S. , Orkin S.H. , Pellegrini M. , Mikkola H.K.
Blood113:3461-3471(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
18.

"Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells."
Liu G.H. , Gerace L.
PLoS ONE4:E7031-E7031(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LIPN1

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