Mef2d ELISA Kit for Rat(Rattus norvegicus) | EIAab.comMef2d ELISA Kit for Rat(Rattus norvegicus)

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Mef2d (Gene name),

Myocyte-specific enhancer factor 2D (Protein name ), MEF2D_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Mef2d;

Protein name:

Myocyte-specific enhancer factor 2D;

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with HDAC4 (in undifferentiating cells); the interaction translocates MEF2D to nuclear dots. Forms a heterodimer with MEF2A (By similarity). Interacts with MAPK7; the interaction phosphorylates but does not activate MEF2D.

Function:

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis.

Subcellular Location:

Nucleus Translocated by HDAC4 to nuclear dots.

Protein Attributes:

Sequence length:

507

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

507:

LDTWTLK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10116.ENSRNOP00000058851

Pfam:

PF12347

String:

O89038

KEGG:

rno:81518

UniGene:

Rn.89018

SMR:

O89038

Uniprot:

O89038

FOR

ELISA Kit for Rat Myocyte-specific enhancer factor 2D

CLIA Kit for Rat Myocyte-specific enhancer factor 2D

Polyclonal Antibody for Rat Myocyte-specific enhancer factor 2D

Monoclonal Antibody for Rat Myocyte-specific enhancer factor 2D

Protein for Rat Myocyte-specific enhancer factor 2D

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1."
Yang C.-C. , Ornatsky O.I. , McDermott J.C. , Cruz T.F. , Prody C.A.
Nucleic Acids Res.26:4771-4777(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH MAPK7
strain: Wistar.
tissue: Heart.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Testis.

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