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Index > Protein center > MELK(Gene name) > Human
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  • MELK (Gene name),
  • Maternal embryonic leucine zipper kinase (Protein name ),  MELK_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MELK(KIAA0175);
    Protein name:
    Maternal embryonic leucine zipper kinase(hMELK);
    Alternative:
    2.7.10.2;Tyrosine-protein kinase MELK);Protein kinase Eg3(pEg3 kinase);Protein kinase PK38(hPK38);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer. Interacts with ZNF622 and PPP1R8.
    Function:
    Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
    Subcellular Location:
    Cell membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    651
    Sequence:
    50:
    MKDYDELLKY | YELHETIGTG | GFAKVKLACH | ILTGEMVAIK | IMDKNTLGSD | 
    100:
    LPRIKTEIEA | LKNLRHQHIC | QLYHVLETAN | KIFMVLEYCP | GGELFDYIIS | 
    150:
    QDRLSEEETR | VVFRQIVSAV | AYVHSQGYAH | RDLKPENLLF | DEYHKLKLID | 
    200:
    FGLCAKPKGN | KDYHLQTCCG | SLAYAAPELI | QGKSYLGSEA | DVWSMGILLY | 
    250:
    VLMCGFLPFD | DDNVMALYKK | IMRGKYDVPK | WLSPSSILLL | QQMLQVDPKK | 
    300:
    RISMKNLLNH | PWIMQDYNYP | VEWQSKNPFI | HLDDDCVTEL | SVHHRNNRQT | 
    350:
    MEDLISLWQY | DHLTATYLLL | LAKKARGKPV | RLRLSSFSCG | QASATPFTDI | 
    400:
    KSNNWSLEDV | TASDKNYVAG | LIDYDWCEDD | LSTGAATPRT | SQFTKYWTES | 
    450:
    NGVESKSLTP | ALCRTPANKL | KNKENVYTPK | SAVKNEEYFM | FPEPKTPVNK | 
    500:
    NQHKREILTT | PNRYTTPSKA | RNQCLKETPI | KIPVNSTGTD | KLMTGVISPE | 
    550:
    RRCRSVELDL | NQAHMEETPK | RKGAKVFGSL | ERGLDKVITV | LTRSKRKGSA | 
    600:
    RDGPRRLKLH | YNVTTTRLVN | PDQLLNEIMS | ILPKKHVDFV | QKGYTLKCQT | 
    650:
    QSDFGKVTMQ | FELEVCQLQK | PDVVGIRRQR | LKGDAWVYKR | LVEDILSSCK | 
    651:
    V
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    String:
    UniGene:
    KEGG:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human hMELK
    Cat.:
    E15058h
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    Packing:
    96T
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    ELISA Kit for Human hMELK
    MSDS:
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    CLIA Kit for Human hMELK
    MSDS:
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    CLIA Kit for Human hMELK
    Cat.:
    U15058h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human hMELK
    Polyclonal Antibody for Human hMELK
    Monoclonal Antibody for Human hMELK
    Monoclonal Antibody for Human hMELK
    Protein for Human hMELK
    Protein for Human hMELK

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Identification of MELK whose expression was highly up-regulated in breast cancers."
      Katagiri T. , Lin M.
      Submitted (2004-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6)
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T. , Seki N. , Ishikawa K. , Tanaka A. , Nomura N.
      DNA Res.3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Bone marrow.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 4; 5; 7 AND 8)
      tissue: Spleen.
      tissue: Testis.
    4. 4.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Colon.
    7. 7.
      "Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38)."
      Seong H.-A. , Gil M. , Kim K.-T. , Kim S.-J. , Ha H.
      Biochem. J.361:597-604(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZNF622;FUNCTION IN PHOSPHORYLATION OF ZNF622
      tissue: Keratinocyte.
    8. 8.
      "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation."
      Davezac N. , Baldin V. , Blot J. , Ducommun B. , Tassan J.P.
      Oncogene21:7630-7641(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CDC25B
    9. 9.
      "Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1."
      Vulsteke V. , Beullens M. , Boudrez A. , Keppens S. , Van Eynde A. , Rider M.H. , Stalmans W. , Bollen M.
      J. Biol. Chem.279:8642-8647(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPP1R8;AUTOPHOSPHORYLATION;MUTAGENESIS OF ASP-150; THR-345; THR-387; THR-409; THR-415; THR-428; THR-446; THR-460; THR-466; THR-478 AND THR-518;PHOSPHORYLATION AT THR-478;FUNCTION
    10. 10.
      "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1."
      Lizcano J.M. , Goeransson O. , Toth R. , Deak M. , Morrice N.A. , Boudeau J. , Hawley S.A. , Udd L. , Maekelae T.P. , Hardie D.G. , Alessi D.R.
      EMBO J.23:833-843(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-167;AUTOPHOSPHORYLATION;MUTAGENESIS OF THR-167
    11. 11.
      "Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers."
      Gray D. , Jubb A.M. , Hogue D. , Dowd P. , Kljavin N. , Yi S. , Bai W. , Frantz G. , Zhang Z. , Koeppen H. , de Sauvage F.J. , Davis D.P.
      Cancer Res.65:9751-9761(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CANCER
    12. 12.
      "CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis."
      Mirey G. , Chartrain I. , Froment C. , Quaranta M. , Bouche J.P. , Monsarrat B. , Tassan J.P. , Ducommun B.
      Cell Cycle4:806-811(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CDC25B
    13. 13.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-505;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-167; SER-343; SER-356; TYR-367; THR-398; THR-409; SER-431; THR-494; SER-505 AND SER-529
    15. 15.
      "Substrate specificity and activity regulation of protein kinase MELK."
      Beullens M. , Vancauwenbergh S. , Morrice N. , Derua R. , Ceulemans H. , Waelkens E. , Bollen M.
      J. Biol. Chem.280:40003-40011(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;ENZYME REGULATION;AUTOPHOSPHORYLATION;CALCIUM-BINDING;PHOSPHORYLATION AT THR-56; TYR-163; THR-167; SER-171; SER-253; SER-336; SER-343; SER-356; SER-391; THR-398; SER-407; SER-431; THR-494; SER-505; SER-529 AND THR-539;MUTAGENESIS OF CYS-29; CYS-70; CYS-89; ASP-150; CYS-154; TYR-163; CYS-168; CYS-169; SER-171; CYS-204; 283-ASP--ASP-285; CYS-286 AND CYS-339
    16. 16.
      "Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells."
      Chartrain I. , Couturier A. , Tassan J.P.
      Biol. Cell98:253-263(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    17. 17.
      "Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family."
      Lin M.L. , Park J.H. , Nishidate T. , Nakamura Y. , Katagiri T.
      Breast Cancer Res.9:R17-R17(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF BCL2L14;MUTAGENESIS OF ASP-150
    18. 18.
      "Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas."
      Marie S.K. , Okamoto O.K. , Uno M. , Hasegawa A.P. , Oba-Shinjo S.M. , Cohen T. , Camargo A.A. , Kosoy A. , Carlotti C.G. Jr. , Toledo S. , Moreira-Filho C.A. , Zago M.A. , Simpson A.J. , Caballero O.L.
      Int. J. Cancer122:807-815(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CANCER
    19. 19.
      "Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells."
      Nakano I. , Masterman-Smith M. , Saigusa K. , Paucar A.A. , Horvath S. , Shoemaker L. , Watanabe M. , Negro A. , Bajpai R. , Howes A. , Lelievre V. , Waschek J.A. , Lazareff J.A. , Freije W.A. , Liau L.M. , Gilbertson R.J. , Cloughesy T.F. , Geschwind D.H. , more...
      J. Neurosci. Res.86:48-60(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CANCER
    20. 20.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356; SER-498; SER-505; THR-518 AND SER-529;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-431 AND SER-505;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    22. 22.
      "Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer."
      Pickard M.R. , Green A.R. , Ellis I.O. , Caldas C. , Hedge V.L. , Mourtada-Maarabouni M. , Williams G.T.
      Breast Cancer Res.11:R60-R60(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CANCER
    23. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356; SER-498; SER-505 AND SER-529;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    24. 24.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    25. 25.
      "Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumor-initiating cells in vivo."
      Hebbard L.W. , Maurer J. , Miller A. , Lesperance J. , Hassell J. , Oshima R.G. , Terskikh A.V.
      Cancer Res.70:8863-8873(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CANCER
    26. 26.
      "Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids."
      Moravcevic K. , Mendrola J.M. , Schmitz K.R. , Wang Y.H. , Slochower D. , Janmey P.A. , Lemmon M.A.
      Cell143:966-977(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    27. 27.
      "Maternal embryonic leucine zipper kinase is stabilized in mitosis by phosphorylation and is partially degraded upon mitotic exit."
      Badouel C. , Chartrain I. , Blot J. , Tassan J.P.
      Exp. Cell Res.316:2166-2173(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE;PHOSPHORYLATION
    28. 28.
      "Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression."
      Choi S. , Ku J.L.
      Biochem. Biophys. Res. Commun.412:207-213(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    29. 29.
      "Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway."
      Nakano I. , Joshi K. , Visnyei K. , Hu B. , Watanabe M. , Lam D. , Wexler E. , Saigusa K. , Nakamura Y. , Laks D.R. , Mischel P.S. , Viapiano M. , Kornblum H.I.
      Neuro-oncol.13:622-634(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
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