"Identification of MELK whose expression was highly up-regulated in breast cancers."
Katagiri T. , Lin M.
Submitted (2004-07) to the EMBL/GenBank/DDBJ databases

"Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
Nagase T. , Seki N. , Ishikawa K. , Tanaka A. , Nomura N.
DNA Res.3:17-24(1996) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , Yamamoto J. , Saito K. , Kawai Y. , Isono Y. , Nakamura Y. , Nagahari K. , Murakami K. , Yasuda T. , Iwayanagi T. , Wagatsuma M. , Shiratori A. , Sudo H. , Hosoiri T. , Kaku Y. , Kodaira H. , Kondo H. , Sugawara M. , Takahashi M. , Kanda K. , Yokoi T. , Furuya T. , Kikkawa E. , Omura Y. , Abe K. , Kamihara K. , Katsuta N. , Sato K. , Tanikawa M. , Yamazaki M. , Ninomiya K. , Ishibashi T. , Yamashita H. , Murakawa K. , Fujimori K. , Tanai H. , Kimata M. , Watanabe M. , Hiraoka S. , Chiba Y. , Ishida S. , Ono Y. , Takiguchi S. , Watanabe S. , Yosida M. , Hotuta T. , Kusano J. , Kanehori K. , Takahashi-Fujii A. , Hara H. , Tanase T.-O. , Nomura Y. , Togiya S. , Komai F. , Hara R. , Takeuchi K. , Arita M. , Imose N. , Musashino K. , Yuuki H. , Oshima A. , Sasaki N. , Aotsuka S. , Yoshikawa Y. , Matsunawa H. , Ichihara T. , Shiohata N. , Sano S. , Moriya S. , Momiyama H. , Satoh N. , Takami S. , Terashima Y. , Suzuki O. , Nakagawa S. , Senoh A. , Mizoguchi H. , Goto Y. , Shimizu F. , Wakebe H. , Hishigaki H. , Watanabe T. , Sugiyama A. , Takemoto M. , Kawakami B. , Yamazaki M. , Watanabe K. , Kumagai A. , Itakura S. , Fukuzumi Y. , Fujimori Y. , Komiyama M. , Tashiro H. , Tanigami A. , Fujiwara T. , Ono T. , Yamada K. , Fujii Y. , Ozaki K. , Hirao M. , Ohmori Y. , Kawabata A. , Hikiji T. , Kobatake N. , Inagaki H. , Ikema Y. , Okamoto S. , Okitani R. , Kawakami T. , Noguchi S. , Itoh T. , Shigeta K. , Senba T. , Matsumura K. , Nakajima Y. , Mizuno T. , Morinaga M. , Sasaki M. , Togashi T. , Oyama M. , Hata H. , Watanabe M. , Komatsu T. , Mizushima-Sugano J. , Satoh T. , Shirai Y. , Takahashi Y. , Nakagawa K. , Okumura K. , Nagase T. , Nomura N. , Kikuchi H. , Masuho Y. , Yamashita R. , Nakai K. , Yada T. , Nakamura Y. , Ohara O. , Isogai T. , Sugano S. more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , Bailey J. , Banerjee R. , Barker D.J. , Barlow K.F. , Bates K. , Beasley H. , Beasley O. , Bird C.P. , Bray-Allen S. , Brown A.J. , Brown J.Y. , Burford D. , Burrill W. , Burton J. , Carder C. , Carter N.P. , Chapman J.C. , Chen Y. , Clarke G. , Clark S.Y. , Clee C.M. , Clegg S. , Collier R.E. , Corby N. , Crosier M. , Cummings A.T. , Davies J. , Dhami P. , Dunn M. , Dutta I. , Dyer L.W. , Earthrowl M.E. , Faulkner L. , Fleming C.J. , Frankish A. , Frankland J.A. , French L. , Fricker D.G. , Garner P. , Garnett J. , Ghori J. , Gilbert J.G.R. , Glison C. , Grafham D.V. , Gribble S. , Griffiths C. , Griffiths-Jones S. , Grocock R. , Guy J. , Hall R.E. , Hammond S. , Harley J.L. , Harrison E.S.I. , Hart E.A. , Heath P.D. , Henderson C.D. , Hopkins B.L. , Howard P.J. , Howden P.J. , Huckle E. , Johnson C. , Johnson D. , Joy A.A. , Kay M. , Keenan S. , Kershaw J.K. , Kimberley A.M. , King A. , Knights A. , Laird G.K. , Langford C. , Lawlor S. , Leongamornlert D.A. , Leversha M. , Lloyd C. , Lloyd D.M. , Lovell J. , Martin S. , Mashreghi-Mohammadi M. , Matthews L. , McLaren S. , McLay K.E. , McMurray A. , Milne S. , Nickerson T. , Nisbett J. , Nordsiek G. , Pearce A.V. , Peck A.I. , Porter K.M. , Pandian R. , Pelan S. , Phillimore B. , Povey S. , Ramsey Y. , Rand V. , Scharfe M. , Sehra H.K. , Shownkeen R. , Sims S.K. , Skuce C.D. , Smith M. , Steward C.A. , Swarbreck D. , Sycamore N. , Tester J. , Thorpe A. , Tracey A. , Tromans A. , Thomas D.W. , Wall M. , Wallis J.M. , West A.P. , Whitehead S.L. , Willey D.L. , Williams S.A. , Wilming L. , Wray P.W. , Young L. , Ashurst J.L. , Coulson A. , Blocker H. , Durbin R.M. , Sulston J.E. , Hubbard T. , Jackson M.J. , Bentley D.R. , Beck S. , Rogers J. , Dunham I. more...
Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , Yooseph S. , Lu F. , Nusskern D.R. , Shue B.C. , Zheng X.H. , Zhong F. , Delcher A.L. , Huson D.H. , Kravitz S.A. , Mouchard L. , Reinert K. , Remington K.A. , Clark A.G. , Waterman M.S. , Eichler E.E. , Adams M.D. , Hunkapiller M.W. , Myers E.W. , Venter J.C. more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38)."
Seong H.-A. , Gil M. , Kim K.-T. , Kim S.-J. , Ha H.
Biochem. J.361:597-604(2002) [PubMed] [Europe PMC] [Abstract]

"Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation."
Davezac N. , Baldin V. , Blot J. , Ducommun B. , Tassan J.P.
Oncogene21:7630-7641(2002) [PubMed] [Europe PMC] [Abstract]

"Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1."
Vulsteke V. , Beullens M. , Boudrez A. , Keppens S. , Van Eynde A. , Rider M.H. , Stalmans W. , Bollen M.
J. Biol. Chem.279:8642-8647(2004) [PubMed] [Europe PMC] [Abstract]

"LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1."
Lizcano J.M. , Goeransson O. , Toth R. , Deak M. , Morrice N.A. , Boudeau J. , Hawley S.A. , Udd L. , Maekelae T.P. , Hardie D.G. , Alessi D.R.
EMBO J.23:833-843(2004) [PubMed] [Europe PMC] [Abstract]

"Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers."
Gray D. , Jubb A.M. , Hogue D. , Dowd P. , Kljavin N. , Yi S. , Bai W. , Frantz G. , Zhang Z. , Koeppen H. , de Sauvage F.J. , Davis D.P.
Cancer Res.65:9751-9761(2005) [PubMed] [Europe PMC] [Abstract]

"CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis."
Mirey G. , Chartrain I. , Froment C. , Quaranta M. , Bouche J.P. , Monsarrat B. , Tassan J.P. , Ducommun B.
Cell Cycle4:806-811(2005) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"M-phase MELK activity is regulated by MPF and MAPK."
Badouel C. , Korner R. , Frank-Vaillant M. , Couturier A. , Nigg E.A. , Tassan J.P.
Cell Cycle5:883-889(2006) [PubMed] [Europe PMC] [Abstract]

"Substrate specificity and activity regulation of protein kinase MELK."
Beullens M. , Vancauwenbergh S. , Morrice N. , Derua R. , Ceulemans H. , Waelkens E. , Bollen M.
J. Biol. Chem.280:40003-40011(2005) [PubMed] [Europe PMC] [Abstract]

"Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells."
Chartrain I. , Couturier A. , Tassan J.P.
Biol. Cell98:253-263(2006) [PubMed] [Europe PMC] [Abstract]

"Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family."
Lin M.L. , Park J.H. , Nishidate T. , Nakamura Y. , Katagiri T.
Breast Cancer Res.9:R17-R17(2007) [PubMed] [Europe PMC] [Abstract]

"Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas."
Marie S.K. , Okamoto O.K. , Uno M. , Hasegawa A.P. , Oba-Shinjo S.M. , Cohen T. , Camargo A.A. , Kosoy A. , Carlotti C.G. Jr. , Toledo S. , Moreira-Filho C.A. , Zago M.A. , Simpson A.J. , Caballero O.L.
Int. J. Cancer122:807-815(2008) [PubMed] [Europe PMC] [Abstract]

"Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells."
Nakano I. , Masterman-Smith M. , Saigusa K. , Paucar A.A. , Horvath S. , Shoemaker L. , Watanabe M. , Negro A. , Bajpai R. , Howes A. , Lelievre V. , Waschek J.A. , Lazareff J.A. , Freije W.A. , Liau L.M. , Gilbertson R.J. , Cloughesy T.F. , Geschwind D.H. , Nelson S.F. , Mischel P.S. , Terskikh A.V. , Kornblum H.I. more...
J. Neurosci. Res.86:48-60(2008) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer."
Pickard M.R. , Green A.R. , Ellis I.O. , Caldas C. , Hedge V.L. , Mourtada-Maarabouni M. , Williams G.T.
Breast Cancer Res.11:R60-R60(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumor-initiating cells in vivo."
Hebbard L.W. , Maurer J. , Miller A. , Lesperance J. , Hassell J. , Oshima R.G. , Terskikh A.V.
Cancer Res.70:8863-8873(2010) [PubMed] [Europe PMC] [Abstract]

"Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids."
Moravcevic K. , Mendrola J.M. , Schmitz K.R. , Wang Y.H. , Slochower D. , Janmey P.A. , Lemmon M.A.
Cell143:966-977(2010) [PubMed] [Europe PMC] [Abstract]

"Maternal embryonic leucine zipper kinase is stabilized in mitosis by phosphorylation and is partially degraded upon mitotic exit."
Badouel C. , Chartrain I. , Blot J. , Tassan J.P.
Exp. Cell Res.316:2166-2173(2010) [PubMed] [Europe PMC] [Abstract]

"Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression."
Choi S. , Ku J.L.
Biochem. Biophys. Res. Commun.412:207-213(2011) [PubMed] [Europe PMC] [Abstract]

"Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway."
Nakano I. , Joshi K. , Visnyei K. , Hu B. , Watanabe M. , Lam D. , Wexler E. , Saigusa K. , Nakamura Y. , Laks D.R. , Mischel P.S. , Viapiano M. , Kornblum H.I.
Neuro-oncol.13:622-634(2011) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , Choudhury B. , Clements J. , Cole J. , Dicks E. , Forbes S. , Gray K. , Halliday K. , Harrison R. , Hills K. , Hinton J. , Jenkinson A. , Jones D. , Menzies A. , Mironenko T. , Perry J. , Raine K. , Richardson D. , Shepherd R. , Small A. , Tofts C. , Varian J. , Webb T. , West S. , Widaa S. , Yates A. , Cahill D.P. , Louis D.N. , Goldstraw P. , Nicholson A.G. , Brasseur F. , Looijenga L. , Weber B.L. , Chiew Y.-E. , DeFazio A. , Greaves M.F. , Green A.R. , Campbell P. , Birney E. , Easton D.F. , Chenevix-Trench G. , Tan M.-H. , Khoo S.K. , Teh B.T. , Yuen S.T. , Leung S.Y. , Wooster R. , Futreal P.A. , Stratton M.R. more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]