Protein name:
Menin ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Interacts with POLR2A phosphorylated at 'Ser-5', but not with the unphosphorylated, nor 'Ser-2' phosphorylated POLR2A forms (By similarity). Interacts with FANCD2 and DBF4 (By similarity). Interacts with SMAD3, but not with SMAD2, nor SMAD4 (By similarity). Directly interacts with NFKB1, NFKB2 and RELA (By similarity). Interacts with JUND.
Function:
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4) (By similarity). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression (By similarity). Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity (By similarity). Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA (By similarity). Positively regulates HOXC8 and HOXC6 gene expression (By similarity). May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair.
Subcellular Location:
Nucleus
May be perinuclear in testis.
Protein Attributes:
50:
MGLKAAQKTL | FPLRSIDDVV | RLFAAELGRE | EPDLVLLSLV | LGFVEHFLAV |
100:
NRVIPTNVPE | LTFQPSPAPD | PPGGLTYFPV | ADLSIIAALY | ARFTAQIRGA |
150:
VDLSLYPREG | GVSSRELVKK | VSDVIWNSLS | RSYFKDRAHI | QSLFSFITGT |
200:
KLDSSGVAFA | VVGACQALGL | RDVHLALSED | HAWVVFGPNG | EQTAEVTWHG |
250:
KGNEDRRGQT | VNAGVAERSW | LYLKGSYMRC | DRKMEVAFMV | CAINPSIDLH |
300:
TDSLELLQLQ | QKLLWLLYDL | GHLERYPMAL | GNLADLEELE | PTPGRPDPLT |
350:
LYHKGIASAK | TYYQDEHIYP | YMYLAGYHCR | NRNVREALQA | WADTATVIQD |
400:
YNYCREDEEI | YKEFFEVAND | VIPNLLKEAA | SLLETGEERT | GEQAQGTQGQ |
450:
GSALQDPECF | AHLLRFYDGI | CKWEEGSPTP | VLHVGWATFL | VQSLGRFEGQ |
500:
VRQKVHIVSR | EAEAAEAEEP | WGDEAREGRR | RGPRRESKPE | EPPPPKKPAL |
550:
DKGPGSGQSA | GSGPPRKTSG | TVPGTTRGGQ | EVGNAAQAPA | PAASPPPEGP |
600:
VLTFQSEKMK | GMKELLVATK | INSSAIKLQL | TAQSQVQMKK | QKVSTPSDYT |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Rat
Mouse
Human
Dog
ELISA Kit for Mouse Menin
ELISA Kit for Mouse Menin
ELISA Kit for Mouse Menin
ELISA Kit for Mouse Menin
ELISA Kit for Mouse Menin
Polyclonal Antibody for Mouse Menin
Polyclonal Antibody for Mouse Menin
Polyclonal Antibody for Mouse Menin
Polyclonal Antibody for Mouse Menin
Polyclonal Antibody for Mouse Menin
Monoclonal Antibody for Mouse Menin
Monoclonal Antibody for Mouse Menin
Monoclonal Antibody for Mouse Menin
Monoclonal Antibody for Mouse Menin
Monoclonal Antibody for Mouse Menin
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
strain :
BALB/c X CBA .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
strain :
129/Ola .
4.
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PubMed ]
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
strain :
129/Sv .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain :
ICR .
tissue :
Brain .
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Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
NOD .
tissue :
Dendritic cell .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain :
FVB/N .
tissue :
Salivary gland .
9.
"Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription."
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH JUND
10.
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Proc. Natl. Acad. Sci. U.S.A.98:1118-1123(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION