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Index > Protein center > Men1(Gene name) > Mouse
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  • Men1 (Gene name),
  • Menin (Protein name ),  MEN1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Men1;
    Protein name:
    Menin;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Interacts with POLR2A phosphorylated at 'Ser-5', but not with the unphosphorylated, nor 'Ser-2' phosphorylated POLR2A forms (By similarity). Interacts with FANCD2 and DBF4 (By similarity). Interacts with SMAD3, but not with SMAD2, nor SMAD4 (By similarity). Directly interacts with NFKB1, NFKB2 and RELA (By similarity). Interacts with JUND.
    Function:
    Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4) (By similarity). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression (By similarity). Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity (By similarity). Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA (By similarity). Positively regulates HOXC8 and HOXC6 gene expression (By similarity). May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair.
    Subcellular Location:
    Nucleus May be perinuclear in testis.
    Protein Attributes:
    Sequence length:
    611
    Sequence:
    50:
    MGLKAAQKTL | FPLRSIDDVV | RLFAAELGRE | EPDLVLLSLV | LGFVEHFLAV | 
    100:
    NRVIPTNVPE | LTFQPSPAPD | PPGGLTYFPV | ADLSIIAALY | ARFTAQIRGA | 
    150:
    VDLSLYPREG | GVSSRELVKK | VSDVIWNSLS | RSYFKDRAHI | QSLFSFITGT | 
    200:
    KLDSSGVAFA | VVGACQALGL | RDVHLALSED | HAWVVFGPNG | EQTAEVTWHG | 
    250:
    KGNEDRRGQT | VNAGVAERSW | LYLKGSYMRC | DRKMEVAFMV | CAINPSIDLH | 
    300:
    TDSLELLQLQ | QKLLWLLYDL | GHLERYPMAL | GNLADLEELE | PTPGRPDPLT | 
    350:
    LYHKGIASAK | TYYQDEHIYP | YMYLAGYHCR | NRNVREALQA | WADTATVIQD | 
    400:
    YNYCREDEEI | YKEFFEVAND | VIPNLLKEAA | SLLETGEERT | GEQAQGTQGQ | 
    450:
    GSALQDPECF | AHLLRFYDGI | CKWEEGSPTP | VLHVGWATFL | VQSLGRFEGQ | 
    500:
    VRQKVHIVSR | EAEAAEAEEP | WGDEAREGRR | RGPRRESKPE | EPPPPKKPAL | 
    550:
    DKGPGSGQSA | GSGPPRKTSG | TVPGTTRGGQ | EVGNAAQAPA | PAASPPPEGP | 
    600:
    VLTFQSEKMK | GMKELLVATK | INSSAIKLQL | TAQSQVQMKK | QKVSTPSDYT | 
    611:
    LSFLKRQRKG | L
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Menin
    ELISA Kit for Mouse Menin
    ELISA Kit for Mouse Menin
    ELISA Kit for Mouse Menin
    ELISA Kit for Mouse Menin
    CLIA Kit for Mouse Menin
    CLIA Kit for Mouse Menin
    CLIA Kit for Mouse Menin
    CLIA Kit for Mouse Menin
    CLIA Kit for Mouse Menin
    Polyclonal Antibody for Mouse Menin
    Polyclonal Antibody for Mouse Menin
    Polyclonal Antibody for Mouse Menin
    Polyclonal Antibody for Mouse Menin
    Polyclonal Antibody for Mouse Menin
    Monoclonal Antibody for Mouse Menin
    Monoclonal Antibody for Mouse Menin
    Monoclonal Antibody for Mouse Menin
    Monoclonal Antibody for Mouse Menin
    Monoclonal Antibody for Mouse Menin
    Protein for Mouse Menin
    Protein for Mouse Menin
    Protein for Mouse Menin
    Protein for Mouse Menin
    Protein for Mouse Menin

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    2. 2.
      "Primary structure, gene expression and chromosomal mapping of rodent homologs of the MEN1 tumor suppressor gene."
      Karges W. , Maier S. , Wissmann A. , Dralle H. , Dosch H.M. , Boehm B.O.
      Biochim. Biophys. Acta1446:286-294(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
      strain: BALB/c X CBA.
    3. 3.
      "Studies of the murine homolog of the multiple endocrine neoplasia type 1 (MEN1) gene, men1."
      Bassett J.H.D. , Rashbass P. , Harding B. , Forbes S.A. , Pannett A.A. , Thakker R.V.
      J. Bone Miner. Res.14:3-10(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
      strain: 129/Ola.
    4. 4.
      "Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene."
      Guru S.C. , Crabtree J.S. , Brown K.D. , Dunn K.J. , Manickam P. , Prasad N.B. , Wangsa D. , Burns A.L. , Spiegel A.M. , Marx S.J. , Pavan W.J. , Collins F.S. , Chandrasekharappa S.C.
      Mamm. Genome10:592-596(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
      strain: 129/Sv.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: ICR.
      tissue: Brain.
    6. 6.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: NOD.
      tissue: Dendritic cell.
    7. 7.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: FVB/N.
      tissue: Salivary gland.
    9. 9.
      "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription."
      Agarwal S.K. , Guru S.C. , Heppner C. , Erdos M.R. , Collins R.M. , Park S.Y. , Saggar S. , Chandrasekharappa S.C. , Collins F.S. , Spiegel A.M. , Marx S.J. , Burns A.L.
      Cell96:143-152(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JUND
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    11. 11.
      "The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression."
      Chen Y.X. , Yan J. , Keeshan K. , Tubbs A.T. , Wang H. , Silva A. , Brown E.J. , Hess J.L. , Pear W.S. , Hua X.
      Proc. Natl. Acad. Sci. U.S.A.103:1018-1023(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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