MFN1 ELISA Kit for Human(Homo sapiens) | EIAab.comMFN1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > MFN1(Gene name) > Human

MFN1 (Gene name),

Mitofusin-1 (Protein name ), MFN1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

MFN1;

Protein name:

Mitofusin-1;

Alternative:

Transmembrane GTPase MFN1;Fzo homolog;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms homomultimers and heteromultimers with MFN2. Multimerization, which is probably mediated by the coiled coil region, may play an essential role in mitochondrion fusion (By similarity). Participates in a high molecular weight multiprotein complex.

Function:

Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.

Subcellular Location:

Isoform 2 Cytoplasm

Protein Attributes:

Sequence length:

741

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

741:

EIDQLEKIQN | NSKLLRNKAV | QLENELENFT | KQFLPSSNEE | S

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000263969

UniGene:

Hs.478383

SMR:

Q8IWA4

MIM:

608506

String:

Q8IWA4

KEGG:

hsa:55669

Pfam:

PF00350

Uniprot:

Q8IWA4

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ELISA Kit for Human Mitofusin-1

Cat.:

E15253h

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MSDS:

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Packing:

96T

ELISA Kit for Human Mitofusin-1

Cat.:

E15253m

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MSDS:

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96T

ELISA Kit for Human Mitofusin-1

Cat.:

E15253r

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MSDS:

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Packing:

96T

CLIA Kit for Human Mitofusin-1

Cat.:

U15253r

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MSDS:

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Packing:

96T

CLIA Kit for Human Mitofusin-1

Cat.:

U15253m

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MSDS:

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Packing:

96T

CLIA Kit for Human Mitofusin-1

Cat.:

U15253h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Mitofusin-1

Cat.:

P15253Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Mitofusin-1

Cat.:

P15253Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Mitofusin-1

Cat.:

P15253Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Mitofusin-1

Protein for Human Mitofusin-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Control of mitochondrial morphology by a human mitofusin."
Santel A. , Fuller M.T.
J. Cell Sci.114:867-874(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;VARIANT ARG-523
tissue: Heart.
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT ARG-523
tissue: Ileal mucosa.
tissue: Trachea.
3.

"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ARG-523
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ARG-523
tissue: Testis.
6.

"Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase."
Hales K.G. , Fuller M.T.
Cell90:121-129(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 138-741 (ISOFORM 3)
tissue: Brain.
7.

Yu W. , Gibbs R.A.
Submitted (1998-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 374-741;VARIANT ARG-523
tissue: Brain.
8.

"Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display."
Chung J.-G. , Yeh K.-T. , Wu S.-L. , Hsu N.-Y. , Chen G.-W. , Yeh Y.-W. , Ho H.-C.
Cancer Res.61:8873-8879(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
9.

"Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo."
Rojo M. , Legros F. , Chateau D. , Lombes A.
J. Cell Sci.115:1663-1674(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
10.

"Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins."
Legros F. , Lombes A. , Frachon P. , Rojo M.
Mol. Biol. Cell13:4343-4354(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells."
Santel A. , Frank S. , Gaume B. , Herrler M. , Youle R.J. , Fuller M.T.
J. Cell Sci.116:2763-2774(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;MUTAGENESIS OF LYS-88 AND THR-109
12.

"Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1."
Park Y.Y. , Lee S. , Karbowski M. , Neutzner A. , Youle R.J. , Cho H.
J. Cell Sci.123:619-626(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY MARCH5
13.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission."
Palmer C.S. , Elgass K.D. , Parton R.G. , Osellame L.D. , Stojanovski D. , Ryan M.T.
J. Biol. Chem.288:27584-27593(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy."
Burchell V.S. , Nelson D.E. , Sanchez-Martinez A. , Delgado-Camprubi M. , Ivatt R.M. , Pogson J.H. , Randle S.J. , Wray S. , Lewis P.A. , Houlden H. , Abramov A.Y. , Hardy J. , Wood N.W. , Whitworth A.J. , Laman H. , Plun-Favreau H.
Nat. Neurosci.16:1257-1265(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
16.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-415

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