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Index > Protein center > SMCR7L(Gene name) > Human
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  • SMCR7L (Gene name),
  • Mitochondrial dynamic protein MID51 (Protein name ),  MID51_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SMCR7L(MID51;MIEF1);
    Protein name:
    Mitochondrial dynamic protein MID51;
    Alternative:
    Mitochondrial elongation factor 1;Mitochondrial dynamic protein of 51 kDa;Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like(SMCR7-like protein);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes: fusion and fission. Seems to have a key role in inhibiting DNM1L-induced mitochondrial fission.
    Subcellular Location:
    Mitochondrion outer membrane Single-pass membrane protein
    Protein Attributes:
    Sequence length:
    463
    Sequence:
    50:
    MAGAGERKGK | KDDNGIGTAI | DFVLSNARLV | LGVGGAAMLG | IATLAVKRMY | 
    100:
    DRAISAPTSP | TRLSHSGKRS | WEEPNWMGSP | RLLNRDMKTG | LSRSLQTLPT | 
    150:
    DSSTFDTDTF | CPPRPKPVAR | KGQVDLKKSR | LRMSLQEKLL | TYYRNRAAIP | 
    200:
    AGEQARAKQA | AVDICAELRS | FLRAKLPDMP | LRDMYLSGSL | YDDLQVVTAD | 
    250:
    HIQLIVPLVL | EQNLWSCIPG | EDTIMNVPGF | FLVRRENPEY | FPRGSSYWDR | 
    300:
    CVVGGYLSPK | TVADTFEKVV | AGSINWPAIG | SLLDYVIRPA | PPPEALTLEV | 
    350:
    QYERDKHLFI | DFLPSVTLGD | TVLVAKPHRL | AQYDNLWRLS | LRPAETARLR | 
    400:
    ALDQADSGCR | SLCLKILKAI | CKSTPALGHL | TASQLTNVIL | HLAQEEADWS | 
    450:
    PDMLADRFLQ | ALRGLISYLE | AGVLPSALNP | KVNLFAELTP | EEIDELGYTL | 
    463:
    YCSLSEPEVL | LQT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    KEGG:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Mitochondrial dynamic protein MID51
    ELISA Kit for Human Mitochondrial dynamic protein MID51
    ELISA Kit for Human Mitochondrial dynamic protein MID51
    CLIA Kit for Human Mitochondrial dynamic protein MID51
    CLIA Kit for Human Mitochondrial dynamic protein MID51
    CLIA Kit for Human Mitochondrial dynamic protein MID51
    Polyclonal Antibody for Human Mitochondrial dynamic protein MID51
    Polyclonal Antibody for Human Mitochondrial dynamic protein MID51
    Polyclonal Antibody for Human Mitochondrial dynamic protein MID51
    Monoclonal Antibody for Human Mitochondrial dynamic protein MID51
    Monoclonal Antibody for Human Mitochondrial dynamic protein MID51
    Monoclonal Antibody for Human Mitochondrial dynamic protein MID51
    Protein for Human Mitochondrial dynamic protein MID51
    Protein for Human Mitochondrial dynamic protein MID51
    Protein for Human Mitochondrial dynamic protein MID51

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Reevaluating human gene annotation: a second-generation analysis of chromosome 22."
      Collins J.E. , Goward M.E. , Cole C.G. , Smink L.J. , Huckle E.J. , Knowles S. , Bye J.M. , Beare D.M. , Dunham I.
      Genome Res.13:27-36(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Testis.
    4. 4.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    7. 7.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55 AND SER-59;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "MiD49 and MiD51, new components of the mitochondrial fission machinery."
      Palmer C.S. , Osellame L.D. , Laine D. , Koutsopoulos O.S. , Frazier A.E. , Ryan M.T.
      EMBO Rep.12:565-573(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION
    10. 10.
      "Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission."
      Zhao J. , Liu T. , Jin S. , Wang X. , Qu M. , Uhlen P. , Tomilin N. , Shupliakov O. , Lendahl U. , Nister M.
      EMBO J.30:2762-2778(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;SUBUNIT;TISSUE SPECIFICITY;INTERACTION WITH DNM1L AND FIS1;FUNCTION
    11. 11.
      "MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission."
      Palmer C.S. , Elgass K.D. , Parton R.G. , Osellame L.D. , Stojanovski D. , Ryan M.T.
      J. Biol. Chem.288:27584-27593(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      "Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission."
      Loson O.C. , Song Z. , Chen H. , Chan D.C.
      Mol. Biol. Cell24:659-667(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DNM1L
    13. 13.
      "Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission."
      Koirala S. , Guo Q. , Kalia R. , Bui H.T. , Eckert D.M. , Frost A. , Shaw J.M.
      Proc. Natl. Acad. Sci. U.S.A.110:E1342-E1351(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    14. 14.
      "Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission."
      Richter V. , Palmer C.S. , Osellame L.D. , Singh A.P. , Elgass K. , Stroud D.A. , Sesaki H. , Kvansakul M. , Ryan M.T.
      J. Cell Biol.204:477-486(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.12 ANGSTROMS) OF 119-463 IN COMPLEXES WITH ADP AND GDP;NUCLEOTIDE-BINDING;FUNCTION;INTERACTION WITH DNM1L;SUBCELLULAR LOCATION;MUTAGENESIS OF HIS-201; ARG-235; 238-PRO--PRO-242; ARG-342; LYS-368 AND LYS-372
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