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Index > Protein center > Mif(Gene name) > Rat
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  • Mif (Gene name),
  • Macrophage migration inhibitory factor (Protein name ),  MIF_RAT from NCBI database.
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  • Gene name:
    Mif;
    Protein name:
    Macrophage migration inhibitory factor(MIF);
    Alternative:
    L-dopachrome isomerase;Glutathione-binding 13 kDa protein;Phenylpyruvate tautomerase;5.3.3.12;L-dopachrome tautomerase);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Homotrimer. Interacts with BNIPL (By similarity). Interacts with the CD74 extracellular domain. Interacts with COPS5 and with the CXCR2 extracellular domain.
    Function:
    Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
    Subcellular Location:
    Secreted Cytoplasm Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens.
    Protein Attributes:
    Sequence length:
    115
    Sequence:
    50:
    MPMFIVNTNV | PRASVPEGFL | SELTQQLAQA | TGKPAQYIAV | HVVPDQLMTF | 
    100:
    SGTSDPCALC | SLHSIGKIGG | AQNRNYSKLL | CGLLSDRLHI | SPDRVYINYY | 
    115:
    DMNAANVGWN | GSTFA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    String:
    KEGG:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat MIF
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    ELISA Kit for Rat MIF
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    ELISA Kit for Rat MIF
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    E0698r
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    ELISA Kit for Rat MIF
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    ELISA Kit for Rat MIF
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    ELISA Kit for Rat MIF
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    E0698c
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    96T
    CLIA Kit for Rat MIF
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    U0698b
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    CLIA Kit for Rat MIF
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    CLIA Kit for Rat MIF
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    96T
    CLIA Kit for Rat MIF
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    CLIA Kit for Rat MIF
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    96T
    CLIA Kit for Rat MIF
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    U0698r
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Rat MIF
    Polyclonal Antibody for Rat MIF
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    P0698Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat MIF
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    P0698Rb-r
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    Polyclonal Antibody for Rat MIF
    Polyclonal Antibody for Rat MIF
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    P0698Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat MIF
    Monoclonal Antibody for Rat MIF
    Monoclonal Antibody for Rat MIF
    Monoclonal Antibody for Rat MIF
    Monoclonal Antibody for Rat MIF
    Monoclonal Antibody for Rat MIF
    Monoclonal Antibody for Rat MIF
    Protein for Rat MIF
    Protein for Rat MIF
    Cat.:
    R0698m
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    Packing:
    1mg
    Purity:
    >90%
    Protein for Rat MIF
    Cat.:
    R0698h
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    Packing:
    1mg
    Purity:
    >90%
    Protein for Rat MIF
    Protein for Rat MIF
    Protein for Rat MIF

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    12% SDS-PAGE analysis

           12% SDS-PAGE analysis

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    Linearity
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    References
    1. 1.
      "Glutathione binding rat liver 13k protein is the homologue of the macrophage migration inhibitory factor."
      Sakai M. , Nishihira J. , Hibiya Y. , Koyama Y. , Nishi S.
      Biochem. Mol. Biol. Int.33:439-446(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    2. 2.
      Wen Y. , Li G. , Bekhor I.
      Submitted (1995-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Lens.
    3. 3.
      Sleeman M.A. , Huckle J.W. , Robinson M. , Jahoda C.A.B. , Reynolds A.J. , Whitehouse C.J.
      Submitted (1996-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: PVG/C.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Pituitary.
    5. 5.
      "Rat liver protein linking chemical and immunological detoxification systems."
      Blocki F.A. , Schlievert P.M. , Wackett L.P.
      Nature360:269-270(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-26
    6. 6.
      Lubec G. , Diao W. , Kang S.U.
      Submitted (2007-07) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-12 AND 79-87;IDENTIFICATION BY MASS SPECTROMETRY
      strain: Sprague-Dawley.
      tissue: Brain.
      tissue: Hippocampus.
    7. 7.
      "Crystal structure of the macrophage migration inhibitory factor from rat liver."
      Suzuki M. , Sugimoto H. , Nakagawa A. , Tanaka I. , Nishihira J. , Sakai M.
      Nat. Struct. Biol.3:259-266(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
      tissue: Liver.
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