Protein name:
Macrophage migration inhibitory factor (MIF) ;
Alternative:
L-dopachrome isomerase ;Glutathione-binding 13 kDa protein ;Phenylpyruvate tautomerase ;5.3.3.12;L-dopachrome tautomerase ) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homotrimer. Interacts with BNIPL (By similarity). Interacts with the CD74 extracellular domain. Interacts with COPS5 and with the CXCR2 extracellular domain.
Function:
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
Subcellular Location:
Secreted
Cytoplasm
Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens.
Protein Attributes:
50:
MPMFIVNTNV | PRASVPEGFL | SELTQQLAQA | TGKPAQYIAV | HVVPDQLMTF |
100:
SGTSDPCALC | SLHSIGKIGG | AQNRNYSKLL | CGLLSDRLHI | SPDRVYINYY |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Pig
Bovine
Rat
Human
Mouse
Chicken
Polyclonal Antibody for Rat MIF
Polyclonal Antibody for Rat MIF
Polyclonal Antibody for Rat MIF
Polyclonal Antibody for Rat MIF
Polyclonal Antibody for Rat MIF
Polyclonal Antibody for Rat MIF
Monoclonal Antibody for Rat MIF
Monoclonal Antibody for Rat MIF
Monoclonal Antibody for Rat MIF
Monoclonal Antibody for Rat MIF
Monoclonal Antibody for Rat MIF
Monoclonal Antibody for Rat MIF
R&D Technical Data
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12% SDS-PAGE analysis
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Liver .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Lens .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
PVG/C .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Pituitary .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-26
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-12 AND 79-87;IDENTIFICATION BY MASS SPECTROMETRY
strain :
Sprague-Dawley .
tissue :
Brain .
tissue :
Hippocampus .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
tissue :
Liver .