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Index > Protein center > RHOT1(Gene name) > Human
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  • RHOT1 (Gene name),
  • Mitochondrial Rho GTPase 1 (Protein name ),  MIRO1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    RHOT1(ARHT1);
    Protein name:
    Mitochondrial Rho GTPase 1(MIRO-1;hMiro-1);
    Alternative:
    Ras homolog gene family member T1;Rac-GTP-binding protein-like protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules.
    Function:
    Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.
    Subcellular Location:
    Mitochondrion outer membrane Single-pass type IV membrane protein
    Protein Attributes:
    Sequence length:
    618
    Sequence:
    50:
    MKKDVRILLV | GEPRVGKTSL | IMSLVSEEFP | EEVPPRAEEI | TIPADVTPER | 
    100:
    VPTHIVDYSE | AEQSDEQLHQ | EISQANVICI | VYAVNNKHSI | DKVTSRWIPL | 
    150:
    INERTDKDSR | LPLILVGNKS | DLVEYSSMET | ILPIMNQYTE | IETCVECSAK | 
    200:
    NLKNISELFY | YAQKAVLHPT | GPLYCPEEKE | MKPACIKALT | RIFKISDQDN | 
    250:
    DGTLNDAELN | FFQRICFNTP | LAPQALEDVK | NVVRKHISDG | VADSGLTLKG | 
    300:
    FLFLHTLFIQ | RGRHETTWTV | LRRFGYDDDL | DLTPEYLFPL | LKIPPDCTTE | 
    350:
    LNHHAYLFLQ | STFDKHDLDR | DCALSPDELK | DLFKVFPYIP | WGPDVNNTVC | 
    400:
    TNERGWITYQ | GFLSQWTLTT | YLDVQRCLEY | LGYLGYSILT | EQESQASAVT | 
    450:
    VTRDKKIDLQ | KKQTQRNVFR | CNVIGVKNCG | KSGVLQALLG | RNLMRQKKIR | 
    500:
    EDHKSYYAIN | TVYVYGQEKY | LLLHDISESE | FLTEAEIICD | VVCLVYDVSN | 
    550:
    PKSFEYCARI | FKQHFMDSRI | PCLIVAAKSD | LHEVKQEYSI | SPTDFCRKHK | 
    600:
    MPPPQAFTCN | TADAPSKDIF | VKLTTMAMYP | HVTQADLKSS | TFWLRASFGA | 
    618:
    TVFAVLGFAM | YKALLKQR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    MIM:
    String:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human MIRO-1
    Cat.:
    E15049h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human MIRO-1
    Cat.:
    E15049m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human MIRO-1
    Cat.:
    E15049c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human MIRO-1
    Cat.:
    E15049b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MIRO-1
    Cat.:
    U15049m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MIRO-1
    Cat.:
    U15049b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MIRO-1
    Cat.:
    U15049c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MIRO-1
    Cat.:
    U15049h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human MIRO-1
    Polyclonal Antibody for Human MIRO-1
    Cat.:
    P15049Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human MIRO-1
    Cat.:
    P15049Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human MIRO-1
    Monoclonal Antibody for Human MIRO-1
    Monoclonal Antibody for Human MIRO-1
    Monoclonal Antibody for Human MIRO-1
    Monoclonal Antibody for Human MIRO-1
    Protein for Human MIRO-1
    Protein for Human MIRO-1
    Protein for Human MIRO-1
    Protein for Human MIRO-1

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    References
    1. 1.
      "Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse."
      Jenne D.E. , Tinschert S. , Dorschner M.O. , Hameister H. , Stephens K. , Kehrer-Sawatzki H.
      Genes Chromosomes Cancer37:111-120(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
    2. 2.
      "Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis."
      Fransson A. , Ruusala A. , Aspenstroem P.
      J. Biol. Chem.278:6495-6502(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;MUTAGENESIS OF PRO-13 AND THR-18
    3. 3.
      "Cloning a novel Rac-GTP binding protein-like gene from human fetal brain."
      Zeng L. , Xie Y. , Mao Y.
      Submitted (2002-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
      tissue: Fetal brain.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Uterus.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 134-618 (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 157-618 (ISOFORM 3)
      tissue: Amygdala.
      tissue: Placenta.
      tissue: Teratocarcinoma.
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-618 (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 90-550 (ISOFORM 6)
      tissue: Brain.
      tissue: Lung.
      tissue: Testis.
      tissue: Uterus.
    7. 8.
      "Rho GTPases have diverse effects on the organization of the actin filament system."
      Aspenstroem P. , Fransson A. , Saras J.
      Biochem. J.377:327-337(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF PRO-13
    8. 9.
      "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking."
      Fransson S. , Ruusala A. , Aspenstroem P.
      Biochem. Biophys. Res. Commun.344:500-510(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TRAK1 AND TRAK2;MUTAGENESIS OF PRO-13; THR-18; GLU-208; GLU-328; LYS-427 AND SER-432
    9. 10.
      "HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport."
      Li Y. , Lim S. , Hoffman D. , Aspenstrom P. , Federoff H.J. , Rempe D.A.
      J. Cell Biol.185:1065-1081(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 12.
      "The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy."
      Bingol B. , Tea J.S. , Phu L. , Reichelt M. , Bakalarski C.E. , Song Q. , Foreman O. , Kirkpatrick D.S. , Sheng M.
      Nature510:370-375(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEUBIQUITINATION
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