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Index > Protein center > Mapk9(Gene name) > Mouse
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  • Mapk9 (Gene name),
  • Mitogen-activated protein kinase 9 (Protein name ),  MK09_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Mapk9(Jnk2;Prkm9);
    Protein name:
    Mitogen-activated protein kinase 9(MAP kinase 9;MAPK 9);
    Alternative:
    c-Jun N-terminal kinase 2;Stress-activated protein kinase JNK2;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with MECOM. Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with NFATC4. Interacts with ATF7; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN.
    Function:
    Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    423
    Sequence:
    50:
    MSDSKSDGQF | YSVQVADSTF | TVLKRYQQLK | PIGSGAQGIV | CAAFDTVLGI | 
    100:
    NVAVKKLSRP | FQNQTHAKRA | YRELVLLKCV | NHKNIISLLN | VFTPQKTLEE | 
    150:
    FQDVYLVMEL | MDANLCQVIH | MELDHERMSY | LLYQMLCGIK | HLHSAGIIHR | 
    200:
    DLKPSNIVVK | SDCTLKILDF | GLARTACTNF | MMTPYVVTRY | YRAPEVILGM | 
    250:
    GYKENVDIWS | VGCIMAEMVL | HKVLFPGRDY | IDQWNKVIEQ | LGTPSAEFMK | 
    300:
    KLQPTVRNYV | ENRPKYPGIK | FEELFPDWIF | PSESERDKIK | TSQARDLLSK | 
    350:
    MLVIDPDKRI | SVDEALRHPY | ITVWYDPAEA | EAPPPQIYDA | QLEEREHAIE | 
    400:
    EWKELIYKEV | MDWEERSKNG | VKDQPSDAAV | SSKATPSQSS | SINDISSMST | 
    423:
    EHTLASDTDS | SLDASTGPLE | GCR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    SMR:
    Pfam:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse MAP kinase 9
    ELISA Kit for Mouse MAP kinase 9
    ELISA Kit for Mouse MAP kinase 9
    ELISA Kit for Mouse MAP kinase 9
    CLIA Kit for Mouse MAP kinase 9
    CLIA Kit for Mouse MAP kinase 9
    CLIA Kit for Mouse MAP kinase 9
    CLIA Kit for Mouse MAP kinase 9
    Polyclonal Antibody for Mouse MAP kinase 9
    Polyclonal Antibody for Mouse MAP kinase 9
    Polyclonal Antibody for Mouse MAP kinase 9
    Polyclonal Antibody for Mouse MAP kinase 9
    Monoclonal Antibody for Mouse MAP kinase 9
    Monoclonal Antibody for Mouse MAP kinase 9
    Monoclonal Antibody for Mouse MAP kinase 9
    Monoclonal Antibody for Mouse MAP kinase 9
    Protein for Mouse MAP kinase 9
    Protein for Mouse MAP kinase 9
    Protein for Mouse MAP kinase 9
    Protein for Mouse MAP kinase 9

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    Precision
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    Linearity
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    References
    1. 1.
      "Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2."
      Yang D.D. , Conze D. , Whitmarsh A.J. , Barrett T. , Davis R.J. , Rincon M. , Flavell R.A.
      Immunity9:575-585(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA-1; ALPHA-2; BETA-1 AND BETA-2);FUNCTION;INDUCTION
    2. 2.
      "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a scaffold factor in the JNK signaling pathway."
      Ito M. , Yoshioka K. , Akechi M. , Yamashita S. , Takamatsu N. , Sugiyama K. , Hibi M. , Nakabeppu Y. , Shiba T. , Yamamoto K.
      Mol. Cell. Biol.19:7539-7548(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-1)
      tissue: Brain.
    3. 3.
      "Analysis of splicing of four mouse JNK/SAPKalpha variants."
      Casanova E. , Callejo A.I. , Calvo P. , Chinchetru M.A.
      NeuroReport11:305-309(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS ALPHA-1; ALPHA-2; BETA-1 AND BETA-2);TISSUE SPECIFICITY
      tissue: Liver.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA-2)
      strain: C57BL/6J.
      tissue: Medulla oblongata.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA-2)
      strain: FVB/N.
      tissue: Salivary gland.
    7. 7.
      "JNK is required for effector T-cell function but not for T-cell activation."
      Dong C. , Yang D.D. , Tournier C. , Whitmarsh A.J. , Xu J. , Davis R.J. , Flavell R.A.
      Nature405:91-94(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;INDUCTION
      tissue: Embryonic stem cell.
      tissue: T-cell.
    8. 8.
      "Requirement of the JIP1 scaffold protein for stress-induced JNK activation."
      Whitmarsh A.J. , Kuan C.-Y. , Kennedy N.J. , Kelkar N. , Haydar T.F. , Mordes J.P. , Appel M. , Rossini A.A. , Jones S.N. , Flavell R.A. , Rakic P. , Davis R.J.
      Genes Dev.15:2421-2432(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
      tissue: Hippocampus.
    9. 9.
      "Common and divergent roles for members of the mouse DCX superfamily."
      Coquelle F.M. , Levy T. , Bergmann S. , Wolf S.G. , Bar-El D. , Sapir T. , Brody Y. , Orr I. , Barkai N. , Eichele G. , Reiner O.
      Cell Cycle5:976-983(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DCLK2
    10. 10.
      "JNK2 is a positive regulator of the cJun transcription factor."
      Jaeschke A. , Karasarides M. , Ventura J.J. , Ehrhardt A. , Zhang C. , Flavell R.A. , Shokat K.M. , Davis R.J.
      Mol. Cell23:899-911(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
      J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-183 AND TYR-185;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
    12. 12.
      "Activity of all JNK isoforms contributes to neurite growth in spiral ganglion neurons."
      Atkinson P.J. , Cho C.H. , Hansen M.R. , Green S.H.
      Hear. Res.278:77-85(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NEURITE GROWTH
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