Gene name:
MKL1 (KIAA1438;MAL) ;
Protein name:
MKL/myocardin-like protein 1 ;
Alternative:
Megakaryocytic acute leukemia protein ;Megakaryoblastic leukemia 1 protein ;Myocardin-related transcription factor A (MRTF-A) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Forms with SCAI and SRF a nuclear ternary complex which binds the CArG consensus motif (CArG box) on DNA via SRF. Interacts with ACTB; interaction with ACTB prevents interaction with SCAI. Interacts with MKL2.
Function:
Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation.
Subcellular Location:
Cytoplasm
Nucleus
Binding to globular actin is required to maintain cytoplasmic localization.
Protein Attributes:
50:
MPPLKSPAAF | HEQRRSLERA | RTEDYLKRKI | RSRPERSELV | RMHILEETSA |
100:
EPSLQAKQLK | LKRARLADDL | NEKIAQRPGP | MELVEKNILP | VESSLKEAII |
150:
VGQVNYPKVA | DSSSFDEDSS | DALSPEQPAS | HESQGSVPSP | LEARVSEPLL |
200:
SATSASPTQV | VSQLPMGRDS | REMLFLAEQP | PLPPPPLLPP | SLTNGTTIPT |
250:
AKSTPTLIKQ | SQPKSASEKS | QRSKKAKELK | PKVKKLKYHQ | YIPPDQKQDR |
300:
GAPPMDSSYA | KILQQQQLFL | QLQILNQQQQ | QHHNYQAILP | APPKSAGEAL |
350:
GSSGTPPVRS | LSTTNSSSSS | GAPGPCGLAR | QNSTSLTGKP | GALPANLDDM |
400:
KVAELKQELK | LRSLPVSGTK | TELIERLRAY | QDQISPVPGA | PKAPAATSIL |
450:
HKAGEVVVAF | PAARLSTGPA | LVAAGLAPAE | VVVATVASSG | VVKFGSTGST |
500:
PPVSPTPSER | SLLSTGDENS | TPGDTFGEMV | TSPLTQLTLQ | ASPLQILVKE |
550:
EGPRAGSCCL | SPGGRAELEG | RDKDQMLQEK | DKQIEALTRM | LRQKQQLVER |
600:
LKLQLEQEKR | AQQPAPAPAP | LGTPVKQENS | FSSCQLSQQP | LGPAHPFNPS |
650:
LAAPATNHID | PCAVAPGPPS | VVVKQEALQP | EPEPVPAPQL | LLGPQGPSLI |
700:
KGVAPPTLIT | DSTGTHLVLT | VTNKNADSPG | LSSGSPQQPS | SQPGSPAPAP |
750:
SAQMDLEHPL | QPLFGTPTSL | LKKEPPGYEE | AMSQQPKQQE | NGSSSQQMDD |
800:
LFDILIQSGE | ISADFKEPPS | LPGKEKPSPK | TVCGSPLAAQ | PSPSAELPQA |
850:
APPPPGSPSL | PGRLEDFLES | STGLPLLTSG | HDGPEPLSLI | DDLHSQMLSS |
900:
TAILDHPPSP | MDTSELHFVP | EPSSTMGLDL | ADGHLDSMDW | LELSSGGPVL |
931:
SLAPLSTTAP | SLFSTDFLDG | HDLQLHWDSC | L
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human MKL/myocardin-like protein 1
ELISA Kit for Human MKL/myocardin-like protein 1
CLIA Kit for Human MKL/myocardin-like protein 1
CLIA Kit for Human MKL/myocardin-like protein 1
Polyclonal Antibody for Human MKL/myocardin-like protein 1
Polyclonal Antibody for Human MKL/myocardin-like protein 1
Monoclonal Antibody for Human MKL/myocardin-like protein 1
Monoclonal Antibody for Human MKL/myocardin-like protein 1
Protein for Human MKL/myocardin-like protein 1
Protein for Human MKL/myocardin-like protein 1
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
"Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia."
Ma Z.
,
Morris S.W.
,
Valentine V.
,
Li M.
,
Herbrick J.-A.
,
Cui X.
,
Bouman D.
,
Li Y.
,
Mehta P.K.
,
Nizetic D.
,
Kaneko Y.
,
Chan G.C.F.
,
Chan L.C.
,
Squire J.
,
Scherer S.W.
,
Hitzler J.K.
Nat. Genet.28:220-221(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];CHROMOSOMAL TRANSLOCATION WITH RBM15
2.
"Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia."
Mercher T.
,
Coniat M.B.-L.
,
Monni R.
,
Mauchauffe M.
,
Khac F.N.
,
Gressin L.
,
Mugneret F.
,
Leblanc T.
,
Dastugue N.
,
Berger R.
,
Bernard O.A.
Proc. Natl. Acad. Sci. U.S.A.98:5776-5779(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];CHROMOSOMAL TRANSLOCATION WITH RBM15
tissue :
Blood .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION
5.
"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E.
,
Wright C.L.
,
Edwards C.A.
,
Davis M.P.
,
Grinham J.A.
,
Cole C.G.
,
Goward M.E.
,
Aguado B.
,
Mallya M.
,
Mokrab Y.
,
Huckle E.J.
,
Beare D.M.
,
Dunham I.
Genome Biol.5:R84.1-R84.11(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLY-648
6.
"The DNA sequence of human chromosome 22."
Dunham I.
,
Hunt A.R.
,
Collins J.E.
,
Bruskiewich R.
,
Beare D.M.
,
Clamp M.
,
Smink L.J.
,
Ainscough R.
,
Almeida J.P.
,
Babbage A.K.
,
Bagguley C.
,
Bailey J.
,
Barlow K.F.
,
Bates K.N.
,
Beasley O.P.
,
Bird C.P.
,
Blakey S.E.
,
Bridgeman A.M.
,
Buck D.
,
Burgess J.
,
Burrill W.D.
,
Burton J.
,
Carder C.
,
Carter N.P.
,
Chen Y.
,
Clark G.
,
Clegg S.M.
,
Cobley V.E.
,
Cole C.G.
,
Collier R.E.
,
Connor R.
,
Conroy D.
,
Corby N.R.
,
Coville G.J.
,
Cox A.V.
,
Davis J.
,
Dawson E.
,
Dhami P.D.
,
Dockree C.
,
Dodsworth S.J.
,
Durbin R.M.
,
Ellington A.G.
,
Evans K.L.
,
Fey J.M.
,
Fleming K.
,
French L.
,
Garner A.A.
,
Gilbert J.G.R.
,
Goward M.E.
,
Grafham D.V.
,
Griffiths M.N.D.
,
Hall C.
,
Hall R.E.
,
Hall-Tamlyn G.
,
Heathcott R.W.
,
Ho S.
,
Holmes S.
,
Hunt S.E.
,
Jones M.C.
,
Kershaw J.
,
Kimberley A.M.
,
King A.
,
Laird G.K.
,
Langford C.F.
,
Leversha M.A.
,
Lloyd C.
,
Lloyd D.M.
,
Martyn I.D.
,
Mashreghi-Mohammadi M.
,
Matthews L.H.
,
Mccann O.T.
,
Mcclay J.
,
Mclaren S.
,
McMurray A.A.
,
Milne S.A.
,
Mortimore B.J.
,
Odell C.N.
,
Pavitt R.
,
Pearce A.V.
,
Pearson D.
,
Phillimore B.J.C.T.
,
Phillips S.H.
,
Plumb R.W.
,
Ramsay H.
,
Ramsey Y.
,
Rogers L.
,
Ross M.T.
,
Scott C.E.
,
Sehra H.K.
,
Skuce C.D.
,
Smalley S.
,
Smith M.L.
,
Soderlund C.
,
Spragon L.
,
Steward C.A.
,
Sulston J.E.
,
Swann R.M.
,
Vaudin M.
,
Wall M.
,
Wallis J.M.
,
Whiteley M.N.
,
Willey D.L.
,
Williams L.
,
Williams S.A.
,
Williamson H.
,
Wilmer T.E.
,
Wilming L.
,
Wright C.L.
,
Hubbard T.
,
Bentley D.R.
,
Beck S.
,
Rogers J.
,
Shimizu N.
,
Minoshima S.
,
Kawasaki K.
,
Sasaki T.
,
Asakawa S.
,
Kudoh J.
,
Shintani A.
,
Shibuya K.
,
Yoshizaki Y.
,
Aoki N.
,
Mitsuyama S.
,
Roe B.A.
,
Chen F.
,
Chu L.
,
Crabtree J.
,
Deschamps S.
,
Do A.
,
Do T.
,
Dorman A.
,
Fang F.
,
Fu Y.
,
Hu P.
,
Hua A.
,
Kenton S.
,
Lai H.
,
Lao H.I.
,
Lewis J.
,
Lewis S.
,
Lin S.-P.
,
Loh P.
,
Malaj E.
,
Nguyen T.
,
Pan H.
,
Phan S.
,
Qi S.
,
Qian Y.
,
Ray L.
,
Ren Q.
,
Shaull S.
,
Sloan D.
,
Song L.
,
Wang Q.
,
Wang Y.
,
Wang Z.
,
White J.
,
Willingham D.
,
Wu H.
,
Yao Z.
,
Zhan M.
,
Zhang G.
,
Chissoe S.
,
Murray J.
,
Miller N.
,
Minx P.
,
Fulton R.
,
Johnson D.
,
Bemis G.
,
Bentley D.
,
Bradshaw H.
,
Bourne S.
,
Cordes M.
,
Du Z.
,
Fulton L.
,
Goela D.
,
Graves T.
,
Hawkins J.
,
Hinds K.
,
Kemp K.
,
Latreille P.
,
Layman D.
,
Ozersky P.
,
Rohlfing T.
,
Scheet P.
,
Walker C.
,
Wamsley A.
,
Wohldmann P.
,
Pepin K.
,
Nelson J.
,
Korf I.
,
Bedell J.A.
,
Hillier L.W.
,
Mardis E.
,
Waterston R.
,
Wilson R.
,
Emanuel B.S.
,
Shaikh T.
,
Kurahashi H.
,
Saitta S.
,
Budarf M.L.
,
McDermid H.E.
,
Johnson A.
,
Wong A.C.C.
,
Morrow B.E.
,
Edelmann L.
,
Kim U.J.
,
Shizuya H.
,
Simon M.I.
,
Dumanski J.P.
,
Peyrard M.
,
Kedra D.
,
Seroussi E.
,
Fransson I.
,
Tapia I.
,
Bruder C.E.
,
O'Brien K.P.
,
Wilkinson P.
,
Bodenteich A.
,
Hartman K.
,
Hu X.
,
Khan A.S.
,
Lane L.
,
Tilahun Y.
,
Wright H.
more...
Nature402:489-495(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
"The full-ORF clone resource of the German cDNA consortium."
Bechtel S.
,
Rosenfelder H.
,
Duda A.
,
Schmidt C.P.
,
Ernst U.
,
Wellenreuther R.
,
Mehrle A.
,
Schuster C.
,
Bahr A.
,
Bloecker H.
,
Heubner D.
,
Hoerlein A.
,
Michel G.
,
Wedler H.
,
Koehrer K.
,
Ottenwaelder B.
,
Poustka A.
,
Wiemann S.
,
Schupp I.
more...
BMC Genomics8:399-399(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 195-931;VARIANT GLY-648
tissue :
Testis .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-305 AND THR-450;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SCAI AND SRF;SUBCELLULAR LOCATION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
13.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-450 AND SER-454;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6; THR-450 AND SER-454;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 336-396