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Index > Protein center > MKL1(Gene name) > Human
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  • MKL1 (Gene name),
  • MKL/myocardin-like protein 1 (Protein name ),  MKL1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MKL1(KIAA1438;MAL);
    Protein name:
    MKL/myocardin-like protein 1;
    Alternative:
    Megakaryocytic acute leukemia protein;Megakaryoblastic leukemia 1 protein;Myocardin-related transcription factor A(MRTF-A);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms with SCAI and SRF a nuclear ternary complex which binds the CArG consensus motif (CArG box) on DNA via SRF. Interacts with ACTB; interaction with ACTB prevents interaction with SCAI. Interacts with MKL2.
    Function:
    Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation.
    Subcellular Location:
    Cytoplasm Nucleus Binding to globular actin is required to maintain cytoplasmic localization.
    Protein Attributes:
    Sequence length:
    931
    Sequence:
    50:
    MPPLKSPAAF | HEQRRSLERA | RTEDYLKRKI | RSRPERSELV | RMHILEETSA | 
    100:
    EPSLQAKQLK | LKRARLADDL | NEKIAQRPGP | MELVEKNILP | VESSLKEAII | 
    150:
    VGQVNYPKVA | DSSSFDEDSS | DALSPEQPAS | HESQGSVPSP | LEARVSEPLL | 
    200:
    SATSASPTQV | VSQLPMGRDS | REMLFLAEQP | PLPPPPLLPP | SLTNGTTIPT | 
    250:
    AKSTPTLIKQ | SQPKSASEKS | QRSKKAKELK | PKVKKLKYHQ | YIPPDQKQDR | 
    300:
    GAPPMDSSYA | KILQQQQLFL | QLQILNQQQQ | QHHNYQAILP | APPKSAGEAL | 
    350:
    GSSGTPPVRS | LSTTNSSSSS | GAPGPCGLAR | QNSTSLTGKP | GALPANLDDM | 
    400:
    KVAELKQELK | LRSLPVSGTK | TELIERLRAY | QDQISPVPGA | PKAPAATSIL | 
    450:
    HKAGEVVVAF | PAARLSTGPA | LVAAGLAPAE | VVVATVASSG | VVKFGSTGST | 
    500:
    PPVSPTPSER | SLLSTGDENS | TPGDTFGEMV | TSPLTQLTLQ | ASPLQILVKE | 
    550:
    EGPRAGSCCL | SPGGRAELEG | RDKDQMLQEK | DKQIEALTRM | LRQKQQLVER | 
    600:
    LKLQLEQEKR | AQQPAPAPAP | LGTPVKQENS | FSSCQLSQQP | LGPAHPFNPS | 
    650:
    LAAPATNHID | PCAVAPGPPS | VVVKQEALQP | EPEPVPAPQL | LLGPQGPSLI | 
    700:
    KGVAPPTLIT | DSTGTHLVLT | VTNKNADSPG | LSSGSPQQPS | SQPGSPAPAP | 
    750:
    SAQMDLEHPL | QPLFGTPTSL | LKKEPPGYEE | AMSQQPKQQE | NGSSSQQMDD | 
    800:
    LFDILIQSGE | ISADFKEPPS | LPGKEKPSPK | TVCGSPLAAQ | PSPSAELPQA | 
    850:
    APPPPGSPSL | PGRLEDFLES | STGLPLLTSG | HDGPEPLSLI | DDLHSQMLSS | 
    900:
    TAILDHPPSP | MDTSELHFVP | EPSSTMGLDL | ADGHLDSMDW | LELSSGGPVL | 
    931:
    SLAPLSTTAP | SLFSTDFLDG | HDLQLHWDSC | L
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    KEGG:
    Pfam:
    UniGene:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human MKL/myocardin-like protein 1
    ELISA Kit for Human MKL/myocardin-like protein 1
    CLIA Kit for Human MKL/myocardin-like protein 1
    CLIA Kit for Human MKL/myocardin-like protein 1
    Polyclonal Antibody for Human MKL/myocardin-like protein 1
    Polyclonal Antibody for Human MKL/myocardin-like protein 1
    Monoclonal Antibody for Human MKL/myocardin-like protein 1
    Monoclonal Antibody for Human MKL/myocardin-like protein 1
    Protein for Human MKL/myocardin-like protein 1
    Protein for Human MKL/myocardin-like protein 1

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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia."
      Ma Z. , Morris S.W. , Valentine V. , Li M. , Herbrick J.-A. , Cui X. , Bouman D. , Li Y. , Mehta P.K. , Nizetic D. , Kaneko Y. , Chan G.C.F. , Chan L.C. , Squire J. , Scherer S.W. , Hitzler J.K.
      Nat. Genet.28:220-221(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHROMOSOMAL TRANSLOCATION WITH RBM15
    2. 2.
      "Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia."
      Mercher T. , Coniat M.B.-L. , Monni R. , Mauchauffe M. , Khac F.N. , Gressin L. , Mugneret F. , Leblanc T. , Dastugue N. , Berger R. , Bernard O.A.
      Proc. Natl. Acad. Sci. U.S.A.98:5776-5779(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHROMOSOMAL TRANSLOCATION WITH RBM15
      tissue: Blood.
    3. 3.
      "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Kikuno R. , Ishikawa K. , Hirosawa M. , Ohara O.
      DNA Res.7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    4. 4.
      "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
      DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLY-648
    6. 6.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 195-931;VARIANT GLY-648
      tissue: Testis.
    8. 8.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-305 AND THR-450;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin."
      Brandt D.T. , Baarlink C. , Kitzing T.M. , Kremmer E. , Ivaska J. , Nollau P. , Grosse R.
      Nat. Cell Biol.11:557-568(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SCAI AND SRF;SUBCELLULAR LOCATION
    12. 12.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    13. 13.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-450 AND SER-454;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6; THR-450 AND SER-454;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "Redox modification of nuclear actin by MICAL-2 regulates SRF signaling."
      Lundquist M.R. , Storaska A.J. , Liu T.C. , Larsen S.D. , Evans T. , Neubig R.R. , Jaffrey S.R.
      Cell156:563-576(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    16. 16.
      "Northeast structural genomics consortium target HR4547E."
      Northeast structural genomics consortium (NESG)
      Submitted (2010-06) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 336-396
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