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Index > Protein center > Tmem67(Gene name) > Rat
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  • Tmem67 (Gene name),
  • Meckelin (Protein name ),  MKS3_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Tmem67(Mks3;Wpk);
    Protein name:
    Meckelin;
    Alternative:
    Transmembrane protein 67;Meckel syndrome type 3 protein homolog;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with DNAJB9, DNAJC10, MKS1 and mutated SFTPC (By similarity). Interacts with SYNE2 during the early establishment of cell polarity.
    Function:
    Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology. Essential for endoplasmic deticulum-associated degradation (ERAD) of surfactant protein C (sftpc).
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Endoplasmic reticulum membrane Multi-pass membrane protein Cytoplasm cytoskeleton cilium basal body
    Protein Attributes:
    Sequence length:
    992
    Sequence:
    50:
    MVMRTRPLAA | MAVRSCFSAL | TGTVYLLLVL | CEVSWAQIFS | FPFQRPETCD | 
    100:
    LNQYFDISAL | SCAPCGANQR | RDALGTSCIC | LPGYHMISNN | GGPSIICKKC | 
    150:
    PENMKGVTKD | GWDCISCPNG | LTAEGKCHCP | SGHILVERNV | SGSLLSQATC | 
    200:
    ELCDGNENSF | TKPNALGTRC | VRCEPTFVNT | SRSCSCSEPH | ISTGGLCFSN | 
    250:
    TGNFPQRLIS | TERYGELGMS | SNSEWFTKYL | QATAAACWTH | SNLTSCQALG | 
    300:
    NMCVMNMNSY | DSTTFDACRL | FHYVFEGAAG | LTGVHSVPFW | RQNLPWLFYG | 
    350:
    DQPGLASQVL | STTPLPTNFS | FKGQNQLKFV | AASYDIRGNF | IRWQTVKGGV | 
    400:
    LQLCPDTERR | LDAAYSFGTT | YQQNCEISLS | KLLADFPSPV | FYDIYLEYTD | 
    450:
    EVQHHYLWAI | PVLNLNLQHN | KLFVNQDSSS | SKWLLTRRIF | LVDAVSGREN | 
    500:
    DLGNQPRVIR | VATQISLSIR | LVPNTKNGNI | YTPLLTIAYS | DIDIKNAYSQ | 
    550:
    SVKISFSVKY | EMNQGDAFVQ | TDIALGVLGG | LAVLSSLLKT | AGWKRRIGSP | 
    600:
    MIDLQTVMKF | LLYYAGDLAN | VFFIITVGTG | LYWLIFFKAQ | KSVSVLLPMP | 
    650:
    VQEERFVTYV | GCAFAMKALQ | FLHKLISQIT | IDIFFIDWER | PKGKVLKAVE | 
    700:
    GEGGVRSATV | PVSIWRTYFV | ANEWNEIQTV | RKINPLFQVL | TTLFFLEVVG | 
    750:
    FKNLALMDPS | SSLSRSLSDY | AAPYSRILRY | AVATTIWLVI | GIVQVVFFAA | 
    800:
    FYERFIEDKI | RQFVDLCSMS | NVSVFLLSHR | CFGYYIHGRS | VHGHADTNME | 
    850:
    DMNMNLRREA | ENLCSQRGLV | PNTDGQTFQI | AVSSQMRQHY | DRIHETLTRR | 
    900:
    NGPARLLSSS | GSTLEQSIKA | YHAMNKFLGS | FIDHVHKEMD | YFIKDKLLLE | 
    950:
    KILGMEFMEP | LEKSIFYNDE | SHSFSSVLYY | GNEATLLIFD | LLFFCVVDLA | 
    992:
    CQNFVLASFL | TYLQQEIFRF | IRNTVGQKNL | ATKTLVDERF | LI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Meckelin
    ELISA Kit for Rat Meckelin
    ELISA Kit for Rat Meckelin
    CLIA Kit for Rat Meckelin
    CLIA Kit for Rat Meckelin
    CLIA Kit for Rat Meckelin
    Polyclonal Antibody for Rat Meckelin
    Polyclonal Antibody for Rat Meckelin
    Polyclonal Antibody for Rat Meckelin
    Monoclonal Antibody for Rat Meckelin
    Monoclonal Antibody for Rat Meckelin
    Monoclonal Antibody for Rat Meckelin
    Protein for Rat Meckelin
    Protein for Rat Meckelin
    Protein for Rat Meckelin

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    2. 2.
      "New rat model that phenotypically resembles autosomal recessive polycystic kidney disease."
      Nauta J. , Goedbloed M.A. , Herck H.V. , Hesselink D.A. , Visser P. , Willemsen R. , Van Dokkum R.P.E. , Wright C.J. , Guay-Woodford L.M.
      J. Am. Soc. Nephrol.11:2272-2284(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION
    3. 3.
      "Meckel-Gruber syndrome protein MKS3 is required for endoplasmic reticulum-associated degradation of surfactant protein C."
      Wang M. , Bridges J.P. , Na C.L. , Xu Y. , Weaver T.E.
      J. Biol. Chem.284:33377-33383(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION
    4. 4.
      "Ciliary and centrosomal defects associated with mutation and depletion of the Meckel syndrome genes MKS1 and MKS3."
      Tammachote R. , Hommerding C.J. , Sinders R.M. , Miller C.A. , Czarnecki P.G. , Leightner A.C. , Salisbury J.L. , Ward C.J. , Torres V.E. , Gattone V.H. II , Harris P.C.
      Hum. Mol. Genet.18:3311-3323(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT WPK LEU-389
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