Gene name:
Tmem67 (Mks3;Wpk) ;
Protein name:
Meckelin ;
Alternative:
Transmembrane protein 67 ;Meckel syndrome type 3 protein homolog ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with DNAJB9, DNAJC10, MKS1 and mutated SFTPC (By similarity). Interacts with SYNE2 during the early establishment of cell polarity.
Function:
Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology. Essential for endoplasmic deticulum-associated degradation (ERAD) of surfactant protein C (sftpc).
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Endoplasmic reticulum membrane
Multi-pass membrane protein
Cytoplasm
cytoskeleton
cilium basal body
Protein Attributes:
50:
MVMRTRPLAA | MAVRSCFSAL | TGTVYLLLVL | CEVSWAQIFS | FPFQRPETCD |
100:
LNQYFDISAL | SCAPCGANQR | RDALGTSCIC | LPGYHMISNN | GGPSIICKKC |
150:
PENMKGVTKD | GWDCISCPNG | LTAEGKCHCP | SGHILVERNV | SGSLLSQATC |
200:
ELCDGNENSF | TKPNALGTRC | VRCEPTFVNT | SRSCSCSEPH | ISTGGLCFSN |
250:
TGNFPQRLIS | TERYGELGMS | SNSEWFTKYL | QATAAACWTH | SNLTSCQALG |
300:
NMCVMNMNSY | DSTTFDACRL | FHYVFEGAAG | LTGVHSVPFW | RQNLPWLFYG |
350:
DQPGLASQVL | STTPLPTNFS | FKGQNQLKFV | AASYDIRGNF | IRWQTVKGGV |
400:
LQLCPDTERR | LDAAYSFGTT | YQQNCEISLS | KLLADFPSPV | FYDIYLEYTD |
450:
EVQHHYLWAI | PVLNLNLQHN | KLFVNQDSSS | SKWLLTRRIF | LVDAVSGREN |
500:
DLGNQPRVIR | VATQISLSIR | LVPNTKNGNI | YTPLLTIAYS | DIDIKNAYSQ |
550:
SVKISFSVKY | EMNQGDAFVQ | TDIALGVLGG | LAVLSSLLKT | AGWKRRIGSP |
600:
MIDLQTVMKF | LLYYAGDLAN | VFFIITVGTG | LYWLIFFKAQ | KSVSVLLPMP |
650:
VQEERFVTYV | GCAFAMKALQ | FLHKLISQIT | IDIFFIDWER | PKGKVLKAVE |
700:
GEGGVRSATV | PVSIWRTYFV | ANEWNEIQTV | RKINPLFQVL | TTLFFLEVVG |
750:
FKNLALMDPS | SSLSRSLSDY | AAPYSRILRY | AVATTIWLVI | GIVQVVFFAA |
800:
FYERFIEDKI | RQFVDLCSMS | NVSVFLLSHR | CFGYYIHGRS | VHGHADTNME |
850:
DMNMNLRREA | ENLCSQRGLV | PNTDGQTFQI | AVSSQMRQHY | DRIHETLTRR |
900:
NGPARLLSSS | GSTLEQSIKA | YHAMNKFLGS | FIDHVHKEMD | YFIKDKLLLE |
950:
KILGMEFMEP | LEKSIFYNDE | SHSFSSVLYY | GNEATLLIFD | LLFFCVVDLA |
992:
CQNFVLASFL | TYLQQEIFRF | IRNTVGQKNL | ATKTLVDERF | LI
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Rat Meckelin
ELISA Kit for Rat Meckelin
ELISA Kit for Rat Meckelin
CLIA Kit for Rat Meckelin
CLIA Kit for Rat Meckelin
CLIA Kit for Rat Meckelin
Polyclonal Antibody for Rat Meckelin
Polyclonal Antibody for Rat Meckelin
Polyclonal Antibody for Rat Meckelin
Monoclonal Antibody for Rat Meckelin
Monoclonal Antibody for Rat Meckelin
Monoclonal Antibody for Rat Meckelin
R&D Technical Data
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Precision
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Recovery
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Linearity
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Brown Norway .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;FUNCTION
4.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
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Nat. Genet.38:191-196(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANT WPK LEU-389