Mlf1 ELISA Kit for Mouse(Mus musculus) | EIAab.comMlf1 ELISA Kit for Mouse(Mus musculus)

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Mlf1 (Gene name),

Myeloid leukemia factor 1 (Protein name ), MLF1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Mlf1(Hls7);

Protein name:

Myeloid leukemia factor 1;

Alternative:

Myelodysplasia-myeloid leukemia factor 1;Hematopoietic lineage switch 7;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with MLF1IP (By similarity). Also interacts with NRBP1/MADM, YWHAZ/14-3-3-zeta and HNRPUL2/MANP. NRBP1 recruits a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 then binds to YWHAZ and is retained in the cytoplasm. Retained in the nucleus by binding to HNRPUL2. Binds to COPS3/CSN3 which is required for suppression of RFWD2 and activation of p53.

Function:

Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

Subcellular Location:

Cytoplasm Nucleus In non-hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus.

Protein Attributes:

Sequence length:

267

Sequence:

50:

100:

150:

200:

250:

267:

FVDKLNVKGS | PVKITKK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF10248

String:

Q9QWV4

UniGene:

Mm.10414

KEGG:

mmu:17349

Uniprot:

Q9QWV4

FOR

ELISA Kit for Mouse Myeloid leukemia factor 1

CLIA Kit for Mouse Myeloid leukemia factor 1

Polyclonal Antibody for Mouse Myeloid leukemia factor 1

Monoclonal Antibody for Mouse Myeloid leukemia factor 1

Protein for Mouse Myeloid leukemia factor 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia."
Hitzler J.K. , Witte D.P. , Jenkins N.A. , Copeland N.G. , Gilbert D.J. , Naeve C.W. , Look A.T. , Morris S.W.
Am. J. Pathol.155:53-59(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
tissue: Testis.
2.

"HLS7, a hemopoietic lineage switch gene homologous to the leukemia-inducing gene MLF1."
Williams J.H. , Daly L.N. , Ingley E. , Beaumont J.G. , Tilbrook P.A. , Lalonde J.-P. , Stillitano J.P. , Klinken S.P.
EMBO J.18:5559-5566(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION
tissue: Embryo.
3.

"MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1."
Lim R. , Winteringham L.N. , Williams J.H. , McCulloch R.K. , Ingley E. , Tiao J.Y.-H. , Lalonde J.-P. , Tsai S. , Tilbrook P.A. , Sun Y. , Wu X. , Morris S.W. , Klinken S.P.
J. Biol. Chem.277:40997-41008(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NRBP1 AND YWHAZ;SUBCELLULAR LOCATION;PHOSPHORYLATION
4.

"Myeloid leukemia factor 1 inhibits erythropoietin-induced differentiation, cell cycle exit and p27Kip1 accumulation."
Winteringham L.N. , Kobelke S. , Williams J.H. , Ingley E. , Klinken S.P.
Oncogene23:5105-5109(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
5.

"Myeloid leukemia factor 1 associates with a novel heterogeneous nuclear ribonucleoprotein U-like molecule."
Winteringham L.N. , Endersby R. , Kobelke S. , McCulloch R.K. , Williams J.H. , Stillitano J. , Cornwall S.M. , Ingley E. , Klinken S.P.
J. Biol. Chem.281:38791-38800(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HNRPUL2 AND YWHAZ;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-34 AND SER-149

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