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Index > Protein center > Mltk(Gene name) > Mouse
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  • Mltk (Gene name),
  • Mitogen-activated protein kinase kinase kinase MLT (Protein name ),  MLTK_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Mltk(Mltk);
    Protein name:
    Mitogen-activated protein kinase kinase kinase MLT;
    Alternative:
    MLK-like mitogen-activated protein triple kinase;Leucine zipper- and sterile alpha motif kinase ZAK;Sterile alpha motif- and leucine zipper-containing kinase AZK;Mixed lineage kinase-related kinase(MLK-related kinase;MRK);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer. Interacts with PKN1 and ZNF33A.
    Function:
    Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.
    Subcellular Location:
    Cytoplasm Nucleus Appears to shuttle between nucleus and cytoplasm.
    Protein Attributes:
    Sequence length:
    802
    Sequence:
    50:
    MSSLGASFVQ | IKFDDLQFFE | NCGGGSFGSV | YRAKWISQDK | EVAVKKLLKI | 
    100:
    EKEAEILSVL | SHRNIIQFYG | VILEPPNYGI | VTEYASLGSL | YDYINSNRSE | 
    150:
    EMDMEHIMTW | ATDVAKGMHY | LHMEAPVKVI | HRDLKSRNVV | IAADGVLKIC | 
    200:
    DFGASRFHNH | TTHMSLVGTF | PWMAPEVIQS | LPVSETCDTY | SYGVVLWEML | 
    250:
    TREVPFKGLE | GLQVAWLVVE | KNERLTIPSS | CPRSFAELLH | QCWEADAKKR | 
    300:
    PSFKQIISIL | ESMSNDTNLP | DQCNSFLHNK | AEWRCEIEAT | LERLKKLERD | 
    350:
    LSFKEQELKE | RERRLKMWEQ | KLTEQSNTPL | LPSFEIGAWT | EDDVYFWVQQ | 
    400:
    LVRKGESSVE | MSGYASLFKE | NNITGKRLLL | LEEEDLKDMG | IVSKGHIIHF | 
    450:
    KSAIEKLTHD | YLNLFHFPPL | IKDSGGEPEE | NEEKIVNLEL | VFGFHLKPGT | 
    500:
    GPQDCKWKMY | MEMDGDEVAI | TYIKDVTFNT | SLPDAEILKM | TKPPFVMEKW | 
    550:
    IVGIAEDQTV | ECTVTYENDV | RTPKLTKHVH | SIQWDRTKPQ | DEVKAVQLAI | 
    600:
    QTLFSSSEGN | PGSRSDSSAD | CQWLDTLRMR | QIASHTSLQR | SQSNPILGSP | 
    650:
    FFPYFANQDS | YAAAVRRTQT | PVKYQQITPS | INPSRSSSPT | QYGLSRNFSS | 
    700:
    LNLSSRDSGF | SSLNDSSSER | GRYSDRSRNK | YYRGSVSLNS | SPKGRYGGKS | 
    750:
    QHSTPSRERY | SGKFYRLPQS | ALNTHQSPDF | KRSPNDHDRR | VPRTIPGMPL | 
    800:
    HPETASKAGE | EESRVSEGGW | TKVEYRKKTH | RQLSAKTSKE | RTRGNYRGRR | 
    802:
    NF
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    SMR:
    Pfam:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Mitogen-activated protein kinase kinase kinase MLT
    Cat.:
    E15205h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Mitogen-activated protein kinase kinase kinase MLT
    Cat.:
    E15205m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Mitogen-activated protein kinase kinase kinase MLT
    Cat.:
    U15205m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Mitogen-activated protein kinase kinase kinase MLT
    Cat.:
    U15205h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase MLT
    Cat.:
    P15205Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase MLT
    Cat.:
    P15205Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase MLT
    Monoclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase MLT
    Protein for Mouse Mitogen-activated protein kinase kinase kinase MLT
    Protein for Mouse Mitogen-activated protein kinase kinase kinase MLT

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Identification and characterization of a novel MAP kinase kinase kinase, MLTK."
      Gotoh I. , Adachi M. , Nishida E.
      J. Biol. Chem.276:4276-4286(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;SUBCELLULAR LOCATION;AUTOPHOSPHORYLATION;HOMODIMERIZATION;MUTAGENESIS OF LYS-45
      tissue: Heart.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
      strain: C57BL/6J.
      tissue: Head.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: FVB/N.
      tissue: Mammary gland.
    4. 4.
      Lubec G. , Kang S.U.
      Submitted (2007-04) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 225-233;IDENTIFICATION BY MASS SPECTROMETRY
      strain: C57BL/6.
      tissue: Brain.
    5. 5.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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