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Index > Protein center > MMP14(Gene name) > Human
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  • MMP14 (Gene name),
  • Matrix metalloproteinase-14 (Protein name ),  MMP14_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MMP14;
    Protein name:
    Matrix metalloproteinase-14(MMP-14);
    Alternative:
    Membrane-type matrix metalloproteinase 1(MT-MMP 1;MTMMP1);MMP-X1;Membrane-type-1 matrix metalloproteinase(MT1-MMP;MT1MMP);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7.
    Subcellular Location:
    Membrane Single-pass type I membrane protein Melanosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
    Protein Attributes:
    Sequence length:
    582
    Sequence:
    50:
    MSPAPRPPRC | LLLPLLTLGT | ALASLGSAQS | SSFSPEAWLQ | QYGYLPPGDL | 
    100:
    RTHTQRSPQS | LSAAIAAMQK | FYGLQVTGKA | DADTMKAMRR | PRCGVPDKFG | 
    150:
    AEIKANVRRK | RYAIQGLKWQ | HNEITFCIQN | YTPKVGEYAT | YEAIRKAFRV | 
    200:
    WESATPLRFR | EVPYAYIREG | HEKQADIMIF | FAEGFHGDST | PFDGEGGFLA | 
    250:
    HAYFPGPNIG | GDTHFDSAEP | WTVRNEDLNG | NDIFLVAVHE | LGHALGLEHS | 
    300:
    SDPSAIMAPF | YQWMDTENFV | LPDDDRRGIQ | QLYGGESGFP | TKMPPQPRTT | 
    350:
    SRPSVPDKPK | NPTYGPNICD | GNFDTVAMLR | GEMFVFKERW | FWRVRNNQVM | 
    400:
    DGYPMPIGQF | WRGLPASINT | AYERKDGKFV | FFKGDKHWVF | DEASLEPGYP | 
    450:
    KHIKELGRGL | PTDKIDAALF | WMPNGKTYFF | RGNKYYRFNE | ELRAVDSEYP | 
    500:
    KNIKVWEGIP | ESPRGSFMGS | DEVFTYFYKG | NKYWKFNNQK | LKVEPGYPKS | 
    550:
    ALRDWMGCPS | GGRPDEGTEE | ETEVIIIEVD | EEGGGAVSAA | AVVLPVLLLL | 
    582:
    LVLAVGLAVF | FFRRHGTPRR | LLYCQRSLLD | KV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    Pfam:
    MIM:
    KEGG:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human MMP-14
    Cat.:
    E2056h
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    MSDS:
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    ELISA Kit for Human MMP-14
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    E2056p
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human MMP-14
    Cat.:
    E2056r
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    96T
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    ELISA Kit for Human MMP-14
    MSDS:
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    ELISA Kit for Human MMP-14
    Cat.:
    E2056b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human MMP-14
    Cat.:
    E2056m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human MMP-14
    Cat.:
    U2056b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human MMP-14
    Cat.:
    U2056p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MMP-14
    Cat.:
    U2056h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MMP-14
    Cat.:
    U2056r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MMP-14
    Cat.:
    U2056m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human MMP-14
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human MMP-14
    Cat.:
    P2056Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human MMP-14
    Cat.:
    P2056Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human MMP-14
    Polyclonal Antibody for Human MMP-14
    Polyclonal Antibody for Human MMP-14
    Polyclonal Antibody for Human MMP-14
    Cat.:
    P2056Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human MMP-14
    Monoclonal Antibody for Human MMP-14
    Monoclonal Antibody for Human MMP-14
    Monoclonal Antibody for Human MMP-14
    Monoclonal Antibody for Human MMP-14
    Monoclonal Antibody for Human MMP-14
    Protein for Human MMP-14
    Protein for Human MMP-14
    Protein for Human MMP-14
    Protein for Human MMP-14
    Protein for Human MMP-14
    Protein for Human MMP-14

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A matrix metalloproteinase expressed on the surface of invasive tumour cells."
      Sato H. , Takino T. , Okada Y. , Cao J. , Shinagawa A. , Yamamoto E. , Seiki M.
      Nature370:61-65(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-8
      tissue: Placenta.
    2. 2.
      "Cloning of a human gene potentially encoding a novel matrix metalloproteinase having a C-terminal transmembrane domain."
      Takino T. , Sato H. , Yamamoto E. , Seiki M.
      Gene155:293-298(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-8
      tissue: Placenta.
    3. 3.
      "Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas."
      Okada A. , Bellocq J.-P. , Rouyer N. , Chenard M.P. , Rio M.C. , Chambon P. , Basset P.
      Proc. Natl. Acad. Sci. U.S.A.92:2730-2734(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-8
    4. 4.
      "cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment."
      Will H. , Hinzmann B.
      Eur. J. Biochem.231:602-608(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-8
      tissue: Lung.
    5. 5.
      Luo G.-X. , Reisfeld R.A. , Strongin A.Y.
      Submitted (1995-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    6. 6.
      "Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate."
      Lohi J.L. , Westermarck J. , Kaehaeri V.M. , Keski-Oja J.
      Eur. J. Biochem.239:239-247(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT SER-8
      tissue: Tongue.
    8. 8.
      NIEHS SNPs program
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS THR-4; LYS-6; SER-8; VAL-233; ASN-273; TRP-302 AND ILE-355
    9. 9.
      "The DNA sequence and analysis of human chromosome 14."
      Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
      Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT SER-8
      tissue: Skin.
    11. 11.
      "Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2."
      Sato H. , Kinoshita T. , Takino T. , Nakayama K. , Seiki M.
      FEBS Lett.393:101-104(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 112-116
    12. 12.
      "Production and activation of matrix metalloproteinase-2 in proliferative diabetic retinopathy."
      Noda K. , Ishida S. , Inoue M. , Obata K. , Oguchi Y. , Okada Y. , Ikeda E.
      Invest. Ophthalmol. Vis. Sci.44:2163-2170(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN THE FORMATION OF THE FIBROVASCULAR TISSUES
    13. 13.
      "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
      Chi A. , Valencia J.C. , Hu Z.-Z. , Watabe H. , Yamaguchi H. , Mangini N.J. , Huang H. , Canfield V.A. , Cheng K.C. , Yang F. , Abe R. , Yamagishi S. , Shabanowitz J. , Hearing V.J. , Wu C. , Appella E. , Hunt D.F.
      J. Proteome Res.5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
      tissue: Melanoma.
    14. 14.
      "The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression."
      Bonnomet A. , Polette M. , Strumane K. , Gilles C. , Dalstein V. , Kileztky C. , Berx G. , van Roy F. , Birembaut P. , Nawrocki-Raby B.
      Oncogene27:3692-3699(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;TISSUE SPECIFICITY
    15. 15.
      "The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis."
      Golubkov V.S. , Chekanov A.V. , Cieplak P. , Aleshin A.E. , Chernov A.V. , Zhu W. , Radichev I.A. , Zhang D. , Dong P.D. , Strongin A.Y.
      J. Biol. Chem.285:35740-35749(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    16. 16.
      "BST-2 binding with cellular MT1-MMP blocks cell growth and migration via decreasing MMP2 activity."
      Gu G. , Zhao D. , Yin Z. , Liu P.
      J. Cell. Biochem.113:1013-1021(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH BST2
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-399
    18. 18.
      "Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor."
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 114-287 IN COMPLEX WITH TIMP2
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      "Mutation of membrane type-1 metalloproteinase, MT1-MMP, causes the multicentric osteolysis and arthritis disease Winchester syndrome."
      Evans B.R. , Mosig R.A. , Lobl M. , Martignetti C.R. , Camacho C. , Grum-Tokars V. , Glucksman M.J. , Martignetti J.A.
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT WNCHRS ARG-17;CHARACTERIZATION OF VARIANT WNCHRS ARG-17
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