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Index > Protein center > MMP17(Gene name) > Human
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  • MMP17 (Gene name),
  • Matrix metalloproteinase-17 (Protein name ),  MMP17_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MMP17(MT4MMP);
    Protein name:
    Matrix metalloproteinase-17(MMP-17);
    Alternative:
    Membrane-type-4 matrix metalloproteinase(MT4-MMP;MT4MMP);Membrane-type matrix metalloproteinase 4(MT-MMP 4;MTMMP4);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
    Subcellular Location:
    Isoform Long Cell membrane Lipid-anchor GPI-anchor Extracellular side Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    603
    Sequence:
    50:
    MRRRAARGPG | PPPPGPGLSR | LPLPLLLLLA | LGTRGGCAAP | APAPRAEDLS | 
    100:
    LGVEWLSRFG | YLPPADPTTG | QLQTQEELSK | AITAMQQFGG | LEATGILDEA | 
    150:
    TLALMKTPRC | SLPDLPVLTQ | ARRRRQAPAP | TKWNKRNLSW | RVRTFPRDSP | 
    200:
    LGHDTVRALM | YYALKVWSDI | APLNFHEVAG | SAADIQIDFS | KADHNDGYPF | 
    250:
    DGPGGTVAHA | FFPGHHHTAG | DTHFDDDEAW | TFRSSDAHGM | DLFAVAVHEF | 
    300:
    GHAIGLSHVA | AAHSIMRPYY | QGPVGDPLRY | GLPYEDKVRV | WQLYGVRESV | 
    350:
    SPTAQPEEPP | LLPEPPDNRS | SAPPRKDVPH | RCSTHFDAVA | QIRGEAFFFK | 
    400:
    GKYFWRLTRD | RHLVSLQPAQ | MHRFWRGLPL | HLDSVDAVYE | RTSDHKIVFF | 
    450:
    KGDRYWVFKD | NNVEEGYPRP | VSDFSLPPGG | IDAAFSWAHN | DRTYFFKDQL | 
    500:
    YWRYDDHTRH | MDPGYPAQSP | LWRGVPSTLD | DAMRWSDGAS | YFFRGQEYWK | 
    550:
    VLDGELEVAP | GYPQSTARDW | LVCGDSQADG | SVAAGVDAAE | GPRAPPGQHD | 
    600:
    QSRSEDGYEV | CSCTSGASSP | PGAPGPLVAA | TMLLLLPPLS | PGALWTAAQA | 
    603:
    LTL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    Pfam:
    String:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human MMP-17
    Cat.:
    E0554h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human MMP-17
    Cat.:
    E0554m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human MMP-17
    Cat.:
    U0554m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MMP-17
    Cat.:
    U0554h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human MMP-17
    Cat.:
    P0554Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human MMP-17
    Cat.:
    P0554Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human MMP-17
    Monoclonal Antibody for Human MMP-17
    Protein for Human MMP-17
    Protein for Human MMP-17

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts."
      Kajita M. , Kinoh H. , Ito N. , Takamura A. , Itoh Y. , Okada A. , Sato H. , Seiki M.
      FEBS Lett.457:353-356(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
      tissue: Monocytic leukemia.
    2. 2.
      Seiki M.
      Submitted (2002-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 41; 44; 202-207; 221 AND 225
    3. 3.
      "Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma."
      Puente X.S. , Pendas A.M. , Llano E. , Velasco G. , Lopez-Otin C.
      Cancer Res.56:944-949(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
      tissue: Mammary carcinoma.
    4. 4.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain."
      Wang Y. , Johnson A.R. , Ye Q.-Z. , Dyer R.D.
      J. Biol. Chem.274:33043-33049(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-299;CHARACTERIZATION
    6. 6.
      "Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase."
      Itoh Y. , Kajita M. , Kinoh H. , Mori H. , Okada A. , Seiki M.
      J. Biol. Chem.274:34260-34266(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GPI-ANCHOR
    7. 7.
      "Biochemical characterization of the catalytic domain of membrane-type 4 matrix metalloproteinase."
      Kolkenbrock H. , Essers L. , Ulbrich N. , Will H.
      Biol. Chem.380:1103-1108(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
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