Gene name:
MMS19 (MMS19L) ;
Protein name:
MMS19 nucleotide excision repair protein homolog (hMMS19) ;
Alternative:
MMS19-like protein ;MET18 homolog ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with FAM96B; the interaction is direct. Interacts with ERCC2/XPD; the interaction is direct. Interacts with ERCC3/XPB and NCOA3/RAC3.
Function:
May play a role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription by interacting with ERCC2/XPD and ERCC3/XPB helicases, both subunits of NER-transcription factor TFIIH. May also function as a transcriptional coactivator of estrogen receptor (ER). May be involved in regulation of ER activity by bridging TFIIH with ER or may facilitate TFIIH-mediated phosphorylation of ER in specific promoters and cell types. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation.
Subcellular Location:
Nucleus
Cytoplasm
cytoskeleton
spindle
Protein Attributes:
50:
MAAAAAVEAA | APMGALWGLV | HDFVVGQQEG | PADQVAADVK | SGNYTVLQVV |
100:
EALGSSLENP | EPRTRARAIQ | LLSQVLLHCH | TLLLEKEVVH | LILFYENRLK |
150:
DHHLVIPSVL | QGLKALSLCV | ALPPGLAVSV | LKAIFQEVHV | QSLPQVDRHT |
200:
VYNIITNFMR | TREEELKSLG | ADFTFGFIQV | MDGEKDPRNL | LVAFRIVHDL |
250:
ISRDYSLGPF | VEELFEVTSC | YFPIDFTPPP | NDPHGIQRED | LILSLRAVLA |
300:
STPRFAEFLL | PLLIEKVDSE | VLSAKLDSLQ | TLNACCAVYG | QKELKDFLPS |
350:
LWASIRREVF | QTASERVEAE | GLAALHSLTA | CLSRSVLRAD | AEDLLDSFLS |
400:
NILQDCRHHL | CEPDMKLVWP | SAKLLQAAAG | ASARACDSVT | SNVLPLLLEQ |
450:
FHKHSQSSQR | RTILEMLLGF | LKLQQKWSYE | DKDQRPLNGF | KDQLCSLVFM |
500:
ALTDPSTQLQ | LVGIRTLTVL | GAQPDLLSYE | DLELAVGHLY | RLSFLKEDSQ |
550:
SCRVAALEAS | GTLAALYPVA | FSSHLVPKLA | EELRVGESNL | TNGDEPTQCS |
600:
RHLCCLQALS | AVSTHPSIVK | ETLPLLLQHL | WQVNRGNMVA | QSSDVIAVCQ |
650:
SLRQMAEKCQ | QDPESCWYFH | QTAIPCLLAL | AVQASMPEKE | PSVLRKVLLE |
700:
DEVLAAMVSV | IGTATTHLSP | ELAAQSVTHI | VPLFLDGNVS | FLPENSFPSR |
750:
FQPFQDGSSG | QRRLIALLMA | FVCSLPRNVE | IPQLNQLMRE | LLELSCCHSC |
800:
PFSSTAAAKC | FAGLLNKHPA | GQQLDEFLQL | AVDKVEAGLG | SGPCRSQAFT |
850:
LLLWVTKALV | LRYHPLSSCL | TARLMGLLSD | PELGPAAADG | FSLLMSDCTD |
900:
VLTRAGHAEV | RIMFRQRFFT | DNVPALVQGF | HAAPQDVKPN | YLKGLSHVLN |
950:
RLPKPVLLPE | LPTLLSLLLE | ALSCPDCVVQ | LSTLSCLQPL | LLEAPQVMSL |
1000:
HVDTLVTKFL | NLSSSPSMAV | RIAALQCMHA | LTRLPTPVLL | PYKPQVIRAL |
1030:
AKPLDDKKRL | VRKEAVSARG | EWFLLGSPGS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Human
Mouse
ELISA Kit for Human hMMS19
ELISA Kit for Human hMMS19
ELISA Kit for Human hMMS19
CLIA Kit for Human hMMS19
CLIA Kit for Human hMMS19
CLIA Kit for Human hMMS19
Polyclonal Antibody for Human hMMS19
Polyclonal Antibody for Human hMMS19
Polyclonal Antibody for Human hMMS19
Monoclonal Antibody for Human hMMS19
Monoclonal Antibody for Human hMMS19
Monoclonal Antibody for Human hMMS19
R&D Technical Data
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Precision
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Recovery
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Linearity
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PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLY-68;FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INTERACTION WITH ERCC2 AND ERCC3
tissue :
Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLY-68;INTERACTION WITH NCOA3;SUBCELLULAR LOCATION
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Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 6);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 48-1030 (ISOFORM 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-1030 (ISOFORM 2);VARIANTS GLY-68 AND ASP-790
tissue :
Teratocarcinoma .
tissue :
Tongue .
tissue :
Trachea .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLY-68; TRP-98; ILE-197; HIS-306; VAL-365; PRO-409; GLU-434; ILE-526; VAL-558; ASP-790 AND HIS-983
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
Mural R.J.
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more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLY-68
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3);VARIANTS GLY-68 AND ASP-790
tissue :
Brain .
tissue :
Lymph .
tissue :
Uterus .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-496;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.
"MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation."
Ito S.
,
Tan L.J.
,
Andoh D.
,
Narita T.
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Seki M.
,
Hirano Y.
,
Narita K.
,
Kuraoka I.
,
Hiraoka Y.
,
Tanaka K.
Mol. Cell39:632-640(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;IDENTIFICATION IN MMXD COMPLEX;INTERACTION WITH FAM96B;SUBCELLULAR LOCATION
12.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
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Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1027;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;IDENTIFICATION IN THE CIA COMPLEX
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;IDENTIFICATION IN THE CIA COMPLEX;SUBCELLULAR LOCATION;INTERACTION WITH RTEL1