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Index > Protein center > MMS19(Gene name) > Human
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  • MMS19 (Gene name),
  • MMS19 nucleotide excision repair protein homolog (Protein name ),  MMS19_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MMS19(MMS19L);
    Protein name:
    MMS19 nucleotide excision repair protein homolog(hMMS19);
    Alternative:
    MMS19-like protein;MET18 homolog;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with FAM96B; the interaction is direct. Interacts with ERCC2/XPD; the interaction is direct. Interacts with ERCC3/XPB and NCOA3/RAC3.
    Function:
    May play a role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription by interacting with ERCC2/XPD and ERCC3/XPB helicases, both subunits of NER-transcription factor TFIIH. May also function as a transcriptional coactivator of estrogen receptor (ER). May be involved in regulation of ER activity by bridging TFIIH with ER or may facilitate TFIIH-mediated phosphorylation of ER in specific promoters and cell types. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation.
    Subcellular Location:
    Nucleus Cytoplasm cytoskeleton spindle
    Protein Attributes:
    Sequence length:
    1030
    Sequence:
    50:
    MAAAAAVEAA | APMGALWGLV | HDFVVGQQEG | PADQVAADVK | SGNYTVLQVV | 
    100:
    EALGSSLENP | EPRTRARAIQ | LLSQVLLHCH | TLLLEKEVVH | LILFYENRLK | 
    150:
    DHHLVIPSVL | QGLKALSLCV | ALPPGLAVSV | LKAIFQEVHV | QSLPQVDRHT | 
    200:
    VYNIITNFMR | TREEELKSLG | ADFTFGFIQV | MDGEKDPRNL | LVAFRIVHDL | 
    250:
    ISRDYSLGPF | VEELFEVTSC | YFPIDFTPPP | NDPHGIQRED | LILSLRAVLA | 
    300:
    STPRFAEFLL | PLLIEKVDSE | VLSAKLDSLQ | TLNACCAVYG | QKELKDFLPS | 
    350:
    LWASIRREVF | QTASERVEAE | GLAALHSLTA | CLSRSVLRAD | AEDLLDSFLS | 
    400:
    NILQDCRHHL | CEPDMKLVWP | SAKLLQAAAG | ASARACDSVT | SNVLPLLLEQ | 
    450:
    FHKHSQSSQR | RTILEMLLGF | LKLQQKWSYE | DKDQRPLNGF | KDQLCSLVFM | 
    500:
    ALTDPSTQLQ | LVGIRTLTVL | GAQPDLLSYE | DLELAVGHLY | RLSFLKEDSQ | 
    550:
    SCRVAALEAS | GTLAALYPVA | FSSHLVPKLA | EELRVGESNL | TNGDEPTQCS | 
    600:
    RHLCCLQALS | AVSTHPSIVK | ETLPLLLQHL | WQVNRGNMVA | QSSDVIAVCQ | 
    650:
    SLRQMAEKCQ | QDPESCWYFH | QTAIPCLLAL | AVQASMPEKE | PSVLRKVLLE | 
    700:
    DEVLAAMVSV | IGTATTHLSP | ELAAQSVTHI | VPLFLDGNVS | FLPENSFPSR | 
    750:
    FQPFQDGSSG | QRRLIALLMA | FVCSLPRNVE | IPQLNQLMRE | LLELSCCHSC | 
    800:
    PFSSTAAAKC | FAGLLNKHPA | GQQLDEFLQL | AVDKVEAGLG | SGPCRSQAFT | 
    850:
    LLLWVTKALV | LRYHPLSSCL | TARLMGLLSD | PELGPAAADG | FSLLMSDCTD | 
    900:
    VLTRAGHAEV | RIMFRQRFFT | DNVPALVQGF | HAAPQDVKPN | YLKGLSHVLN | 
    950:
    RLPKPVLLPE | LPTLLSLLLE | ALSCPDCVVQ | LSTLSCLQPL | LLEAPQVMSL | 
    1000:
    HVDTLVTKFL | NLSSSPSMAV | RIAALQCMHA | LTRLPTPVLL | PYKPQVIRAL | 
    1030:
    AKPLDDKKRL | VRKEAVSARG | EWFLLGSPGS | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    MIM:
    UniGene:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human hMMS19
    ELISA Kit for Human hMMS19
    ELISA Kit for Human hMMS19
    CLIA Kit for Human hMMS19
    CLIA Kit for Human hMMS19
    CLIA Kit for Human hMMS19
    Polyclonal Antibody for Human hMMS19
    Polyclonal Antibody for Human hMMS19
    Polyclonal Antibody for Human hMMS19
    Monoclonal Antibody for Human hMMS19
    Monoclonal Antibody for Human hMMS19
    Monoclonal Antibody for Human hMMS19
    Protein for Human hMMS19
    Protein for Human hMMS19
    Protein for Human hMMS19

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning of a human homolog of the yeast nucleotide excision repair gene MMS19 and interaction with transcription repair factor TFIIH via the XPB and XPD helicases."
      Seroz T. , Winkler G.S. , Auriol J. , Verhage R.A. , Vermeulen W. , Smit B. , Brouwer J. , Eker A.P.M. , Weeda G. , Egly J.-M. , Hoeijmakers J.H.J.
      Nucleic Acids Res.28:4506-4513(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLY-68;FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INTERACTION WITH ERCC2 AND ERCC3
      tissue: Cervix carcinoma.
    2. 2.
      "The human homologue of the yeast DNA repair and TFIIH regulator MMS19 is an AF-1-specific coactivator of estrogen receptor."
      Wu X. , Li H. , Chen J.D.
      J. Biol. Chem.276:23962-23968(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLY-68;INTERACTION WITH NCOA3;SUBCELLULAR LOCATION
    3. 3.
      "Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant."
      Queimado L. , Rao M. , Schultz R.A. , Koonin E.V. , Aravind L. , Nardo T. , Stefanini M. , Friedberg E.C.
      Nucleic Acids Res.29:1884-1891(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;VARIANT GLY-68
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 6);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 48-1030 (ISOFORM 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-1030 (ISOFORM 2);VARIANTS GLY-68 AND ASP-790
      tissue: Teratocarcinoma.
      tissue: Tongue.
      tissue: Trachea.
    5. 5.
      NIEHS SNPs program
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLY-68; TRP-98; ILE-197; HIS-306; VAL-365; PRO-409; GLU-434; ILE-526; VAL-558; ASP-790 AND HIS-983
    6. 6.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLY-68
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3);VARIANTS GLY-68 AND ASP-790
      tissue: Brain.
      tissue: Lymph.
      tissue: Uterus.
    9. 9.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    10. 10.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-496;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation."
      Ito S. , Tan L.J. , Andoh D. , Narita T. , Seki M. , Hirano Y. , Narita K. , Kuraoka I. , Hiraoka Y. , Tanaka K.
      Mol. Cell39:632-640(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN MMXD COMPLEX;INTERACTION WITH FAM96B;SUBCELLULAR LOCATION
    12. 12.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1027;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      "MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity."
      Stehling O. , Vashisht A.A. , Mascarenhas J. , Jonsson Z.O. , Sharma T. , Netz D.J. , Pierik A.J. , Wohlschlegel J.A. , Lill R.
      Science337:195-199(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN THE CIA COMPLEX
    15. 15.
      "MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism."
      Gari K. , Leon Ortiz A.M. , Borel V. , Flynn H. , Skehel J.M. , Boulton S.J.
      Science337:243-245(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN THE CIA COMPLEX;SUBCELLULAR LOCATION;INTERACTION WITH RTEL1
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