MOCS2 ELISA Kit for Human(Homo sapiens) | EIAab.comMOCS2 ELISA Kit for Human(Homo sapiens)

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MOCS2 (Gene name),

Molybdopterin synthase sulfur carrier subunit (Protein name ), MOC2A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MOCS2(MOCO1);

Protein name:

Molybdopterin synthase sulfur carrier subunit;

Alternative:

Molybdenum cofactor synthesis protein 2 small subunit;MOCO1-A;Molybdopterin-synthase small subunit;Molybdenum cofactor synthesis protein 2A(MOCS2A);Sulfur carrier protein MOCS2A;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.

Function:

Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.

Subcellular Location:

Cytoplasm cytosol

Protein Attributes:

Sequence length:

Sequence:

50:

88:

VRNQIIFAVR | QEYVELGDQL | LVLQPGDEIA | VIPPISGG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

O96033

MIM:

252160

MIM:

252150

UniGene:

Hs.163645

String:

O96033

Pfam:

PF02597

KEGG:

hsa:4338

Uniprot:

O96033

FOR

ELISA Kit for Human Molybdopterin synthase sulfur carrier subunit

CLIA Kit for Human Molybdopterin synthase sulfur carrier subunit

Polyclonal Antibody for Human Molybdopterin synthase sulfur carrier subunit

Monoclonal Antibody for Human Molybdopterin synthase sulfur carrier subunit

Protein for Human Molybdopterin synthase sulfur carrier subunit

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Human molybdopterin synthase gene: identification of a bicistronic transcript with overlapping reading frames."
Stallmeyer B. , Drugeon G. , Reiss J. , Haenni A.L. , Mendel R.R.
Am. J. Hum. Genet.64:698-705(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];IDENTIFICATION OF BICISTRONIC GENE;TISSUE SPECIFICITY
tissue: Liver.
2.

"The two subunits of human molybdopterin synthase: evidence for a bicistronic messenger RNA with overlapping reading frames."
Sloan J. , Kinghorn J.R. , Unkles S.E.
Nucleic Acids Res.27:854-858(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
3.

"Mechanistic studies of human molybdopterin synthase reaction and characterization of mutants identified in group B patients of molybdenum cofactor deficiency."
Leimkuehler S. , Freuer A. , Araujo J.A. , Rajagopalan K.V. , Mendel R.R.
J. Biol. Chem.278:26127-26134(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;THIOCARBOXYLATION AT GLY-88;CHARACTERIZATION OF VARIANT MOCODB PHE-7
4.

"Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans."
Matthies A. , Rajagopalan K.V. , Mendel R.R. , Leimkuehler S.
Proc. Natl. Acad. Sci. U.S.A.101:5946-5951(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;AMPYLATION AT GLY-88;THIOCARBOXYLATION AT GLY-88
5.

"Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry."
Matthies A. , Nimtz M. , Leimkuehler S.
Biochemistry44:7912-7920(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: THIOCARBOXYLATION AT GLY-88
6.

"Site-directed mutagenesis of the active site loop of the rhodanese-like domain of the human molybdopterin synthase sulfurase MOCS3. Major differences in substrate specificity between eukaryotic and bacterial homologs."
Krepinsky K. , Leimkuehler S.
FEBS J.274:2778-2787(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: THIOCARBOXYLATION AT GLY-88
7.

"The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins."
Schmitz J. , Chowdhury M.M. , Haenzelmann P. , Nimtz M. , Lee E.Y. , Schindelin H. , Leimkuehler S.
Biochemistry47:6479-6489(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: THIOCARBOXYLATION AT GLY-88
8.

"Human molybdopterin synthase gene: genomic structure and mutations in molybdenum cofactor deficiency type B."
Reiss J. , Dorche C. , Stallmeyer B. , Mendel R.R. , Cohen N. , Zabot M.-T.
Am. J. Hum. Genet.64:706-711(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MOCODB
9.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"Molybdopterin synthase mutations in a mild case of molybdenum cofactor deficiency."
Johnson J.L. , Coyne K.E. , Rajagopalan K.V. , Van Hove J.L.K. , Mackay M. , Pitt J. , Boneh A.
Am. J. Med. Genet.104:169-173(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MOCODB PHE-7
11.

"Ten novel mutations in the molybdenum cofactor genes MOCS1 and MOCS2 and in vitro characterization of a MOCS2 mutation that abolishes the binding ability of molybdopterin synthase."
Leimkuehler S. , Charcosset M. , Latour P. , Dorche C. , Kleppe S. , Scaglia F. , Szymczak I. , Schupp P. , Hahnewald R. , Reiss J.
Hum. Genet.117:565-570(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MOCODB
12.

"A novel MOCS2 mutation reveals coordinated expression of the small and large subunit of molybdopterin synthase."
Hahnewald R. , Leimkuehler S. , Vilaseca A. , Acquaviva-Bourdain C. , Lenz U. , Reiss J.
Mol. Genet. Metab.89:210-213(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MOCODB

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