Mpdz ELISA Kit for Rat(Rattus norvegicus) | EIAab.comMpdz ELISA Kit for Rat(Rattus norvegicus)

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Mpdz (Gene name),

Multiple PDZ domain protein (Protein name ), MPDZ_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Mpdz(Mupp1);

Protein name:

Multiple PDZ domain protein;

Alternative:

Multi-PDZ domain protein 1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with F11R/JAM, CLDN1, NG2, CXADR, CRB1, MPP4 and MPP5, HTR2A, HTR2B, PLEKHA1/TAPP1 and PLEKHA2/TAPP2. Interacts with CXADR (By similarity). Interacts with HTR2C, CLDN5, DLG4, GRIN1, SYNGAP1, CAMK2A and CAMK2B. Interacts with the adenovirus type 9 E4-ORF1 protein and the HPV18 E6 protein.

Function:

Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.

Subcellular Location:

Endomembrane system Cell junction tight junction Apical cell membrane Cell junction synapse Apical cell membrane Cell junction synapse postsynaptic cell membrane postsynaptic density Cell projection dendrite Cell junction synapse synaptosome Associated with membranes. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR. In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane (By similarity). Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4.

Protein Attributes:

Sequence length:

2054

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MVLS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.6684

KEGG:

rno:29365

String:

O55164

STRING:

10116.ENSRNOP00000059212

SMR:

O55164

Pfam:

PF09045

Uniprot:

O55164

FOR

ELISA Kit for Rat Multiple PDZ domain protein

CLIA Kit for Rat Multiple PDZ domain protein

Polyclonal Antibody for Rat Multiple PDZ domain protein

Monoclonal Antibody for Rat Multiple PDZ domain protein

Protein for Rat Multiple PDZ domain protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and characterization of MUPP1, a novel PDZ domain protein."
Ullmer C. , Schmuck K. , Figge A. , Luebbert H.
FEBS Lett.424:63-68(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
2.

"Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins."
Lee S.S. , Glaunsinger B. , Mantovani F. , Banks L. , Javier R.T.
J. Virol.74:9680-9693(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ADENOVIRUS TYPE 9 E4-ORF1 PROTEIN AND HPV18 E6 PROTEIN;SUBCELLULAR LOCATION;DOMAINS
3.

"Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1."
Becamel C. , Figge A. , Poliak S. , Dumuis A. , Peles E. , Bockaert J. , Luebbert H. , Ullmer C.
J. Biol. Chem.276:12974-12982(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HTR2C;TISSUE SPECIFICITY;DOMAIN;SUBCELLULAR LOCATION;FUNCTION
4.

"Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells."
Poliak S. , Matlis S. , Ullmer C. , Scherer S.S. , Peles E.
J. Cell Biol.159:361-372(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH CLDN5
5.

"SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation."
Krapivinsky G. , Medina I. , Krapivinsky L. , Gapon S. , Clapham D.E.
Neuron43:563-574(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH DLG4; GRIN1; SYNGAP1; CAMK2A AND CAMK2B;FUNCTION
6.

"A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins."
Feng W. , Long J.-F. , Zhang M.
Proc. Natl. Acad. Sci. U.S.A.102:6861-6866(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 21-59;INTERACTION WITH MPP5

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