CDC25B ELISA Kit for Human(Homo sapiens) | EIAab.comCDC25B ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CDC25B(Gene name) > Human

CDC25B (Gene name),

M-phase inducer phosphatase 2 (Protein name ), MPIP2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CDC25B(CDC25HU2);

Protein name:

M-phase inducer phosphatase 2;

Alternative:

Dual specificity phosphatase Cdc25B;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.

Subcellular Location:

Cytoplasm cytoskeleton centrosome Cytoplasm cytoskeleton spindle pole

Protein Attributes:

Sequence length:

580

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

580:

KDELKTFRLK | TRSWAGERSR | RELCSRLQDQ |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000245960

KEGG:

hsa:994

String:

P30305

UniGene:

Hs.153752

MIM:

116949

Pfam:

PF06617

SMR:

P30305

Uniprot:

P30305

FOR

ELISA Kit for Human M-phase inducer phosphatase 2

CLIA Kit for Human M-phase inducer phosphatase 2

Polyclonal Antibody for Human M-phase inducer phosphatase 2

Monoclonal Antibody for Human M-phase inducer phosphatase 2

Protein for Human M-phase inducer phosphatase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins."
Galaktionov K.I. , Beach D.
Cell67:1181-1194(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"An additional homolog of the fission yeast cdc25+ gene occurs in humans and is highly expressed in some cancer cells."
Nagata A. , Igarashi M. , Jinno S. , Suto K. , Okayama H.
New Biol.3:959-968(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Alternative splicing of the human CDC25B tyrosine phosphatase. Possible implications for growth control?"
Baldin V. , Cans C. , Superti-Furga G. , Docommun B.
Oncogene14:2485-2495(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 2 AND 3)
4.

NIEHS SNPs program
Submitted (2003-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT LYS-548
5.

"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Brain.
8.

"Alternative splicing of cdc25B."
McCormack A.K. , DeSouza C.C.P.C. , Tonks I.D. , Clark J.M. , Forrest A.R.R. , Hayward N.K. , Ellem K.A.O. , Gabrielli B.G.
Submitted (1997-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 56-352 (ISOFORMS 2 AND 3)
9.

"Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase."
Bulavin D.V. , Higashimoto Y. , Popoff I.J. , Gaarde W.A. , Basrur V. , Potapova O. , Appella E. , Fornace A.J. Jr.
Nature411:102-107(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-323 AND SER-375;INTERACTION WITH MAPK14 AND 14-3-3 PROTEINS
10.

"Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation."
Davezac N. , Baldin V. , Blot J. , Ducommun B. , Tassan J.P.
Oncogene21:7630-7641(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-323
11.

"Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function."
Lu R. , Niida H. , Nakanishi M.
J. Biol. Chem.279:31164-31170(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-375
tissue: Testis.
12.

"Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition."
Dutertre S. , Cazales M. , Quaranta M. , Froment C. , Trabut V. , Dozier C. , Mirey G. , Bouche J.P. , Theis-Febvre N. , Schmitt E. , Monsarrat B. , Prigent C. , Ducommun B.
J. Cell Sci.117:2523-2531(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-353 BY AURKA
13.

"Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase."
Kraemer A. , Mailand N. , Lukas C. , Syljuaesen R.G. , Wilkinson C.J. , Nigg E.A. , Bartek J. , Lukas J.
Nat. Cell Biol.6:884-891(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION BY CHEK1
14.

"CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis."
Mirey G. , Chartrain I. , Froment C. , Quaranta M. , Bouche J.P. , Monsarrat B. , Tassan J.P. , Ducommun B.
Cell Cycle4:806-811(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-169;SUBCELLULAR LOCATION
15.

"MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation."
Manke I.A. , Nguyen A. , Lim D. , Stewart M.Q. , Elia A.E. , Yaffe M.B.
Mol. Cell17:37-48(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-323 BY MAPKAPK2
16.

"Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis."
Schmidt A. , Durgan J. , Magalhaes A. , Hall A.
EMBO J.26:1624-1636(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION
17.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
18.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-249;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
19.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle."
Reynolds R.A. , Yem A.W. , Wolfe C.L. , Deibel M.R. Jr. , Chidester C.G. , Watenpaugh K.D.
J. Mol. Biol.293:559-568(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.91 ANGSTROMS) OF 370-580

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