CDC25C ELISA Kit for Human(Homo sapiens) | EIAab.comCDC25C ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CDC25C(Gene name) > Human

CDC25C (Gene name),

M-phase inducer phosphatase 3 (Protein name ), MPIP3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CDC25C;

Protein name:

M-phase inducer phosphatase 3;

Alternative:

Dual specificity phosphatase Cdc25C;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity.

Function:

Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDK1 and activate its kinase activity.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

473

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

473:

SKVQEGERQL | REQIALLVKD | MSP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:995

String:

P30307

UniGene:

Hs.656

STRING:

9606.ENSP00000321656

SMR:

P30307

Pfam:

PF06617

MIM:

157680

Uniprot:

P30307

FOR

ELISA Kit for Human M-phase inducer phosphatase 3

CLIA Kit for Human M-phase inducer phosphatase 3

Polyclonal Antibody for Human M-phase inducer phosphatase 3

Monoclonal Antibody for Human M-phase inducer phosphatase 3

Protein for Human M-phase inducer phosphatase 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2."
Sadhu K. , Reed B.I. , Richardson H. , Russell P.
Proc. Natl. Acad. Sci. U.S.A.87:5139-5143(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT CYS-70
2.

"An additional transcript of the cdc25C gene from A431 cells encodes a functional protein."
Bureik M. , Rief N. , Drescher R. , Jungbluth A. , Montenarh M. , Wagner P.
Int. J. Oncol.17:1251-1258(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
3.

NIEHS SNPs program
Submitted (2003-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT CYS-70
tissue: Skin.
6.

"Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C."
Wegener S. , Hampe W. , Herrmann D. , Schaller H.C.
Eur. J. Cell Biol.79:810-815(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-210 (ISOFORMS 2; 4 AND 5);VARIANT CYS-70
7.

"Differential expression of cdc25 cell-cycle-activating phosphatases in human colorectal carcinoma."
Hernandez S. , Bessa X. , Bea S. , Hernandez L. , Nadal A. , Mallofre C. , Muntane J. , Castells A. , Fernandez P.L. , Cardesa A. , Campo E.
Lab. Invest.81:465-473(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
tissue: Colon carcinoma.
8.

"Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis."
Strausfeld U. , Fernandez A. , Capony J.P. , Girard F. , Lautredou N. , Derancourt J. , Labbe J.C. , Lamb N.J.
J. Biol. Chem.269:5989-6000(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT THR-48; THR-67; SER-122; THR-130; SER-168 AND SER-214
9.

"The physical association and phosphorylation of Cdc25C protein phosphatase by Prk."
Ouyang B. , Li W. , Pan H. , Meadows J. , Hoffmann I. , Dai W.
Oncogene18:6029-6036(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY PLK3
10.

"The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase."
Roshak A.K. , Capper E.A. , Imburgia C. , Fornwald J. , Scott G. , Marshall L.A.
Cell. Signal.12:405-411(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY PLK1
11.

"Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase."
Bulavin D.V. , Higashimoto Y. , Popoff I.J. , Gaarde W.A. , Basrur V. , Potapova O. , Appella E. , Fornace A.J. Jr.
Nature411:102-107(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-216;INTERACTION WITH MAPK14 AND 14-3-3 PROTEINS
12.

"Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates."
Elia A.E. , Cantley L.C. , Yaffe M.B.
Science299:1228-1231(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLK1;MUTAGENESIS OF SER-129 AND THR-130
13.

"Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function."
Lu R. , Niida H. , Nakanishi M.
J. Biol. Chem.279:31164-31170(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-216
tissue: Testis.
14.

"Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation."
Bahassi el M. , Hennigan R.F. , Myer D.L. , Stambrook P.J.
Oncogene23:2658-2663(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-191 AND SER-198;MUTAGENESIS OF SER-191
15.

"The human immunodeficiency virus Vpr protein binds Cdc25C: implications for G2 arrest."
Goh W.C. , Manel N. , Emerman M.
Virology318:337-349(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV-1 VPR;MUTAGENESIS OF GLU-352 AND LYS-359
16.

"MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation."
Manke I.A. , Nguyen A. , Lim D. , Stewart M.Q. , Elia A.E. , Yaffe M.B.
Mol. Cell17:37-48(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-216 BY MAPKAPK2
17.

"Human Plk4 phosphorylates Cdc25C."
Bonni S. , Ganuelas M.L. , Petrinac S. , Hudson J.W.
Cell Cycle7:545-547(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY PLK4
18.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64; SER-168 AND SER-472;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61 (ISOFORMS 4 AND 5);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
19.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38; THR-48; SER-57; SER-61; SER-64 AND THR-67;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
20.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61; SER-64 AND THR-67;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
21.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]

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