MRAP ELISA Kit for Human(Homo sapiens) | EIAab.comMRAP ELISA Kit for Human(Homo sapiens)

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MRAP (Gene name),

Melanocortin-2 receptor accessory protein (Protein name ), MRAP_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MRAP(C21orf61;FALP);

Protein name:

Melanocortin-2 receptor accessory protein;

Alternative:

Fat cell-specific low molecular weight protein;B27;Fat tissue-specific low MW protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with MC2R.

Function:

Required for MC2R expression in certain cell types, suggesting that it is involved in the processing, trafficking or function of MC2R. May be involved in the intracellular trafficking pathways in adipocyte cells.

Subcellular Location:

Cytoplasm perinuclear region Cytoplasm Cell membrane Endoplasmic reticulum Concentrated at the perinuclear membrane region. Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm (By similarity). Localizes both to plasma membrane and endoplasmic reticulum.

Protein Attributes:

Sequence length:

172

Sequence:

50:

100:

150:

172:

GPLVRSKPSE | PPPGDRTSQL | QS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000306697

Pfam:

PF15183

MIM:

607398

String:

Q8TCY5

UniGene:

Hs.584940

KEGG:

hsa:56246

Uniprot:

Q8TCY5

FOR

ELISA Kit for Human Melanocortin-2 receptor accessory protein

CLIA Kit for Human Melanocortin-2 receptor accessory protein

Polyclonal Antibody for Human Melanocortin-2 receptor accessory protein

Monoclonal Antibody for Human Melanocortin-2 receptor accessory protein

Protein for Human Melanocortin-2 receptor accessory protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells."
Xu A. , Choi K.-L. , Wang Y. , Permana P.A. , Xu L.Y. , Bogardus C. , Cooper G.J.S.
Biochem. Biophys. Res. Commun.293:1161-1167(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
tissue: Adipocyte.
2.

"Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis."
Gardiner K. , Slavov D. , Bechtel L. , Davisson M.
Genomics79:833-843(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4)
tissue: Brain.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue: Thyroid.
4.

"MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family."
Chan L.F. , Webb T.R. , Chung T.T. , Meimaridou E. , Cooray S.N. , Guasti L. , Chapple J.P. , Egertova M. , Elphick M.R. , Cheetham M.E. , Metherell L.A. , Clark A.J.
Proc. Natl. Acad. Sci. U.S.A.106:6146-6151(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;INTERACTION WITH MC1R; MC2R; MC3R; MC4R; MC5R AND MRAP2
5.

"Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2."
Sebag J.A. , Hinkle P.M.
Sci. Signal.3:RA28-RA28(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;TOPOLOGY;INTERACTION WITH MC2R AND MRAP2
6.

"Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2."
Metherell L.A. , Chapple J.P. , Cooray S. , David A. , Becker C. , Rueschendorf F. , Naville D. , Begeot M. , Khoo B. , Nuernberg P. , Huebner A. , Cheetham M.E. , Clark A.J.L.
Nat. Genet.37:166-170(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN GCCD2;FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH MC2R

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