Cdc42bpb ELISA Kit for Rat(Rattus norvegicus) | EIAab.comCdc42bpb ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Cdc42bpb(Gene name) > Rat

Cdc42bpb (Gene name),

Serine/threonine-protein kinase MRCK beta (Protein name ), MRCKB_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cdc42bpb;

Protein name:

Serine/threonine-protein kinase MRCK beta;

Alternative:

DMPK-like beta;CDC42-binding protein kinase beta;Myotonic dystrophy kinase-related CDC42-binding kinase beta(MRCK beta;Myotonic dystrophy protein kinase-like beta);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42 (By similarity). Interacts with TJP1; this interaction requires the presence of catalytically active CDC42.

Function:

Serine/threonine-protein kinase that plays a role in the regulation of cytoskeleton reorganization, cell migration, wound healing and invasion. Acts as a downstream effector of CDC42. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation.

Subcellular Location:

Cytoplasm Cell membrane Peripheral membrane protein Cytoplasmic side Cell junction Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). Detected at the leading edge of migrating and wounded cells; this localization requires the presence of catalytically active CDC42.

Protein Attributes:

Sequence length:

1713

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1713:

LPLEGLDQPA | CDA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.105815

SMR:

Q7TT49

KEGG:

rno:113960

String:

Q7TT49

Pfam:

PF00130

Uniprot:

Q7TT49

FOR

ELISA Kit for Rat Serine/threonine-protein kinase MRCK beta

CLIA Kit for Rat Serine/threonine-protein kinase MRCK beta

Polyclonal Antibody for Rat Serine/threonine-protein kinase MRCK beta

Monoclonal Antibody for Rat Serine/threonine-protein kinase MRCK beta

Protein for Rat Serine/threonine-protein kinase MRCK beta

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization."
Leung T. , Chen X.-Q. , Tan I. , Manser E. , Lim L.
Mol. Cell. Biol.18:130-140(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
tissue: Brain.
2.

Huang C.Q. , Wu S.L. , Cheng Z.
Submitted (2003-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow."
Tan I. , Yong J. , Dong J.M. , Lim L. , Leung T.
Cell135:123-136(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH LURAP1 AND MYO18A
4.

"Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration."
Huo L. , Wen W. , Wang R. , Kam C. , Xia J. , Feng W. , Zhang M.
EMBO J.30:665-678(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TJP1;MUTAGENESIS OF PHE-952; TYR-954; LEU-964 AND PHE-966;SUBCELLULAR LOCATION
5.

"Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase."
Tan I. , Lai J. , Yong J. , Li S.F. , Leung T.
FEBS Lett.585:1260-1268(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF PPP1R12A AND MYL9/MLC2;ENZYME REGULATION

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