Gene name:
ABCC3 (CMOAT2;MLP2;MRP3) ;
Protein name:
Canalicular multispecific organic anion transporter 2 ;
Alternative:
Multi-specific organic anion transporter D (MOAT-D) ;ATP-binding cassette sub-family C member 3 ;Multidrug resistance-associated protein 3 ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MDALCGSGEL | GSKFWDSNLS | VHTENPDLTP | CFQNSLLAWV | PCIYLWVALP |
100:
CYLLYLRHHC | RGYIILSHLS | KLKMVLGVLL | WCVSWADLFY | SFHGLVHGRA |
150:
PAPVFFVTPL | VVGVTMLLAT | LLIQYERLQG | VQSSGVLIIF | WFLCVVCAIV |
200:
PFRSKILLAK | AEGEISDPFR | FTTFYIHFAL | VLSALILACF | REKPPFFSAK |
250:
NVDPNPYPET | SAGFLSRLFF | WWFTKMAIYG | YRHPLEEKDL | WSLKEEDRSQ |
300:
MVVQQLLEAW | RKQEKQTARH | KASAAPGKNA | SGEDEVLLGA | RPRPRKPSFL |
350:
KALLATFGSS | FLISACFKLI | QDLLSFINPQ | LLSILIRFIS | NPMAPSWWGF |
400:
LVAGLMFLCS | MMQSLILQHY | YHYIFVTGVK | FRTGIMGVIY | RKALVITNSV |
450:
KRASTVGEIV | NLMSVDAQRF | MDLAPFLNLL | WSAPLQIILA | IYFLWQNLGP |
500:
SVLAGVAFMV | LLIPLNGAVA | VKMRAFQVKQ | MKLKDSRIKL | MSEILNGIKV |
550:
LKLYAWEPSF | LKQVEGIRQG | ELQLLRTAAY | LHTTTTFTWM | CSPFLVTLIT |
600:
LWVYVYVDPN | NVLDAEKAFV | SVSLFNILRL | PLNMLPQLIS | NLTQASVSLK |
650:
RIQQFLSQEE | LDPQSVERKT | ISPGYAITIH | SGTFTWAQDL | PPTLHSLDIQ |
700:
VPKGALVAVV | GPVGCGKSSL | VSALLGEMEK | LEGKVHMKGS | VAYVPQQAWI |
750:
QNCTLQENVL | FGKALNPKRY | QQTLEACALL | ADLEMLPGGD | QTEIGEKGIN |
800:
LSGGQRQRVS | LARAVYSDAD | IFLLDDPLSA | VDSHVAKHIF | DHVIGPEGVL |
850:
AGKTRVLVTH | GISFLPQTDF | IIVLADGQVS | EMGPYPALLQ | RNGSFANFLC |
900:
NYAPDEDQGH | LEDSWTALEG | AEDKEALLIE | DTLSNHTDLT | DNDPVTYVVQ |
950:
KQFMRQLSAL | SSDGEGQGRP | VPRRHLGPSE | KVQVTEAKAD | GALTQEEKAA |
1000:
IGTVELSVFW | DYAKAVGLCT | TLAICLLYVG | QSAAAIGANV | WLSAWTNDAM |
1050:
ADSRQNNTSL | RLGVYAALGI | LQGFLVMLAA | MAMAAGGIQA | ARVLHQALLH |
1100:
NKIRSPQSFF | DTTPSGRILN | CFSKDIYVVD | EVLAPVILML | LNSFFNAIST |
1150:
LVVIMASTPL | FTVVILPLAV | LYTLVQRFYA | ATSRQLKRLE | SVSRSPIYSH |
1200:
FSETVTGASV | IRAYNRSRDF | EIISDTKVDA | NQRSCYPYII | SNRWLSIGVE |
1250:
FVGNCVVLFA | ALFAVIGRSS | LNPGLVGLSV | SYSLQVTFAL | NWMIRMMSDL |
1300:
ESNIVAVERV | KEYSKTETEA | PWVVEGSRPP | EGWPPRGEVE | FRNYSVRYRP |
1350:
GLDLVLRDLS | LHVHGGEKVG | IVGRTGAGKS | SMTLCLFRIL | EAAKGEIRID |
1400:
GLNVADIGLH | DLRSQLTIIP | QDPILFSGTL | RMNLDPFGSY | SEEDIWWALE |
1450:
LSHLHTFVSS | QPAGLDFQCS | EGGENLSVGQ | RQLVCLARAL | LRKSRILVLD |
1500:
EATAAIDLET | DNLIQATIRT | QFDTCTVLTI | AHRLNTIMDY | TRVLVLDKGV |
1527:
VAEFDSPANL | IAARGIFYGM | ARDAGLA
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Human Canalicular multispecific organic anion transporter 2
ELISA Kit for Human Canalicular multispecific organic anion transporter 2
ELISA Kit for Human Canalicular multispecific organic anion transporter 2
CLIA Kit for Human Canalicular multispecific organic anion transporter 2
CLIA Kit for Human Canalicular multispecific organic anion transporter 2
CLIA Kit for Human Canalicular multispecific organic anion transporter 2
Polyclonal Antibody for Human Canalicular multispecific organic anion transporter 2
Polyclonal Antibody for Human Canalicular multispecific organic anion transporter 2
Polyclonal Antibody for Human Canalicular multispecific organic anion transporter 2
Monoclonal Antibody for Human Canalicular multispecific organic anion transporter 2
Monoclonal Antibody for Human Canalicular multispecific organic anion transporter 2
Monoclonal Antibody for Human Canalicular multispecific organic anion transporter 2
Protein for Human Canalicular multispecific organic anion transporter 2
Protein for Human Canalicular multispecific organic anion transporter 2
Protein for Human Canalicular multispecific organic anion transporter 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport."
Uchiumi T.
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Hinoshita E.
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Haga S.
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Nakamura T.
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Tanaka T.
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Toh S.
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Furukawa M.
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Kawabe T.
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Wada M.
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Kuwano M.
Biochem. Biophys. Res. Commun.252:103-110(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Liver .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)
tissue :
Liver .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Liver .
6.
"Complete coding sequence of human MRP3, a homolog of the human multidrug resistance-associated protein MRP1."
Kool M.
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de Haas M.
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Ponne N.J.
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Baas F.
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Borst P.
Submitted (1997-06) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Liver .
7.
"Identification of a novel splice variant of MRP3 involved in resistance to DNA damaging agents."
Auclair D.
,
Alonso E.
,
Chen L.B.
Submitted (1999-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
tissue :
Colon carcinoma .
8.
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C.
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Garber M.
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Adams D.J.
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Sharpe T.
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Major J.E.
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Nguyen C.
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Nicol R.
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O'Leary S.B.
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Schwartz D.C.
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Shaw-Smith C.
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Stankiewicz P.
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Steward C.
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Swarbreck D.
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Venkataraman V.
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Whittaker C.A.
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Yang X.
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Zimmer A.R.
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Bradley A.
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Birren B.W.
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Rogers J.
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Lander E.S.
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Nusbaum C.
more...
Nature440:1045-1049(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
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Halpern A.L.
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Mobarry C.M.
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Lippert R.
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Walenz B.
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Shatkay H.
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Dew I.
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Miller J.R.
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Flanigan M.J.
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Edwards N.J.
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Bolanos R.
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Fasulo D.
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Halldorsson B.V.
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Hannenhalli S.
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Turner R.
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Yooseph S.
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Lu F.
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Nusskern D.R.
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Shue B.C.
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Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
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more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5)
tissue :
Blood .
11.
"Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines."
Kool M.
,
de Haas M.
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Scheffer G.L.
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Scheper R.J.
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van Eijk M.J.
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Cancer Res.57:3537-3547(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1043-1527 (ISOFORM 1)
tissue :
Liver .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .