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Index > Protein center > ABCC4(Gene name) > Human
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  • ABCC4 (Gene name),
  • Multidrug resistance-associated protein 4 (Protein name ),  MRP4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ABCC4(MRP4);
    Protein name:
    Multidrug resistance-associated protein 4;
    Alternative:
    MRP/cMOAT-related ABC transporter;ATP-binding cassette sub-family C member 4;Multi-specific organic anion transporter B(MOAT-B);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    May be an organic anion pump relevant to cellular detoxification.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1325
    Sequence:
    50:
    MLPVYQEVKP | NPLQDANLCS | RVFFWWLNPL | FKIGHKRRLE | EDDMYSVLPE | 
    100:
    DRSQHLGEEL | QGFWDKEVLR | AENDAQKPSL | TRAIIKCYWK | SYLVLGIFTL | 
    150:
    IEESAKVIQP | IFLGKIINYF | ENYDPMDSVA | LNTAYAYATV | LTFCTLILAI | 
    200:
    LHHLYFYHVQ | CAGMRLRVAM | CHMIYRKALR | LSNMAMGKTT | TGQIVNLLSN | 
    250:
    DVNKFDQVTV | FLHFLWAGPL | QAIAVTALLW | MEIGISCLAG | MAVLIILLPL | 
    300:
    QSCFGKLFSS | LRSKTATFTD | ARIRTMNEVI | TGIRIIKMYA | WEKSFSNLIT | 
    350:
    NLRKKEISKI | LRSSCLRGMN | LASFFSASKI | IVFVTFTTYV | LLGSVITASR | 
    400:
    VFVAVTLYGA | VRLTVTLFFP | SAIERVSEAI | VSIRRIQTFL | LLDEISQRNR | 
    450:
    QLPSDGKKMV | HVQDFTAFWD | KASETPTLQG | LSFTVRPGEL | LAVVGPVGAG | 
    500:
    KSSLLSAVLG | ELAPSHGLVS | VHGRIAYVSQ | QPWVFSGTLR | SNILFGKKYE | 
    550:
    KERYEKVIKA | CALKKDLQLL | EDGDLTVIGD | RGTTLSGGQK | ARVNLARAVY | 
    600:
    QDADIYLLDD | PLSAVDAEVS | RHLFELCICQ | ILHEKITILV | THQLQYLKAA | 
    650:
    SQILILKDGK | MVQKGTYTEF | LKSGIDFGSL | LKKDNEESEQ | PPVPGTPTLR | 
    700:
    NRTFSESSVW | SQQSSRPSLK | DGALESQDTE | NVPVTLSEEN | RSEGKVGFQA | 
    750:
    YKNYFRAGAH | WIVFIFLILL | NTAAQVAYVL | QDWWLSYWAN | KQSMLNVTVN | 
    800:
    GGGNVTEKLD | LNWYLGIYSG | LTVATVLFGI | ARSLLVFYVL | VNSSQTLHNK | 
    850:
    MFESILKAPV | LFFDRNPIGR | ILNRFSKDIG | HLDDLLPLTF | LDFIQTLLQV | 
    900:
    VGVVSVAVAV | IPWIAIPLVP | LGIIFIFLRR | YFLETSRDVK | RLESTTRSPV | 
    950:
    FSHLSSSLQG | LWTIRAYKAE | ERCQELFDAH | QDLHSEAWFL | FLTTSRWFAV | 
    1000:
    RLDAICAMFV | IIVAFGSLIL | AKTLDAGQVG | LALSYALTLM | GMFQWCVRQS | 
    1050:
    AEVENMMISV | ERVIEYTDLE | KEAPWEYQKR | PPPAWPHEGV | IIFDNVNFMY | 
    1100:
    SPGGPLVLKH | LTALIKSQEK | VGIVGRTGAG | KSSLISALFR | LSEPEGKIWI | 
    1150:
    DKILTTEIGL | HDLRKKMSII | PQEPVLFTGT | MRKNLDPFNE | HTDEELWNAL | 
    1200:
    QEVQLKETIE | DLPGKMDTEL | AESGSNFSVG | QRQLVCLARA | ILRKNQILII | 
    1250:
    DEATANVDPR | TDELIQKKIR | EKFAHCTVLT | IAHRLNTIID | SDKIMVLDSG | 
    1300:
    RLKEYDEPYV | LLQNKESLFY | KMVQQLGKAE | AAALTETAKQ | VYFKRNYPHI | 
    1325:
    GHTDHMVTNT | SNGQPSTLTI | FETAL
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    UniGene:
    KEGG:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Multidrug resistance-associated protein 4
    Cat.:
    E10402h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Multidrug resistance-associated protein 4
    Cat.:
    U10402h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Multidrug resistance-associated protein 4
    Cat.:
    P10402Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Multidrug resistance-associated protein 4
    Protein for Human Multidrug resistance-associated protein 4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter."
      Lee K. , Belinsky M.G. , Bell D.W. , Testa J.R. , Kruh G.D.
      Cancer Res.58:2741-2747(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ILE-18
    2. 2.
      "Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing."
      Adachi M. , Sampath J. , Lan L.B. , Sun D. , Hargrove P. , Flatley R. , Tatum A. , Edwards M.Z. , Wezeman M. , Matherly L. , Drake R. , Schuetz J.
      J. Biol. Chem.277:38998-39004(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ILE-18
    3. 3.
      Kato R. , Ishikawa T.
      Submitted (2002-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
      tissue: Kidney.
    4. 4.
      "The DNA sequence and analysis of human chromosome 13."
      Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
      Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Brain.
    7. 7.
      "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines."
      Kool M. , de Haas M. , Scheffer G.L. , Scheper R.J. , van Eijk M.J. , Juijn J.A. , Baas F. , Borst P.
      Cancer Res.57:3537-3547(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1155-1316 (ISOFORMS 1/2)
      tissue: Brain.
    8. 8.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    11. 11.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4."
      Hayashi H. , Naoi S. , Nakagawa T. , Nishikawa T. , Fukuda H. , Imajoh-Ohmi S. , Kondo A. , Kubo K. , Yabuki T. , Hattori A. , Hirouchi M. , Sugiyama Y.
      J. Biol. Chem.287:15054-15065(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNX27
    14. 14.
      "6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4."
      Janke D. , Mehralivand S. , Strand D. , Goedtel-Armbrust U. , Habermeier A. , Gradhand U. , Fischer C. , Toliat M.R. , Fritz P. , Zanger U.M. , Schwab M. , Fromm M.F. , Nuernberg P. , Wojnowski L. , Closs E.I. , Lang T.
      Hum. Mutat.29:659-669(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-556; ILE-776; ILE-820; PHE-854 AND VAL-866;CHARACTERIZATION OF VARIANTS TRP-187; ASN-304; GLU-487; CYS-556; LYS-757; ILE-776; ILE-820; PHE-854; VAL-866 AND MET-1142
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LYS-757
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