ABCC6 ELISA Kit for Human(Homo sapiens) | EIAab.comABCC6 ELISA Kit for Human(Homo sapiens)

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ABCC6 (Gene name),

Multidrug resistance-associated protein 6 (Protein name ), MRP6_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ABCC6(ARA;MRP6);

Protein name:

Multidrug resistance-associated protein 6;

Alternative:

Anthracycline resistance-associated protein;ATP-binding cassette sub-family C member 6;Multi-specific organic anion transporter E(MOAT-E);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).

Subcellular Location:

Membrane Multi-pass membrane protein Localized to the basolateral membrane.

Protein Attributes:

Sequence length:

1503

Sequence:

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1400:

1450:

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1503:

GLV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

O95255

KEGG:

hsa:368

MIM:

264800

MIM:

177850

Pfam:

PF00664

UniGene:

Hs.442182

STRING:

9606.ENSP00000205557

String:

O95255

Uniprot:

O95255

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ELISA Kit for Human Multidrug resistance-associated protein 6

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E10404h

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96T

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ELISA Kit for Human Multidrug resistance-associated protein 6

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E10404m

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96T

ELISA Kit for Human Multidrug resistance-associated protein 6

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E10404r

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96T

CLIA Kit for Human Multidrug resistance-associated protein 6

Cat.:

U10404r

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96T

CLIA Kit for Human Multidrug resistance-associated protein 6

Cat.:

U10404m

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MSDS:

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Packing:

96T

CLIA Kit for Human Multidrug resistance-associated protein 6

Cat.:

U10404h

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96T

Polyclonal Antibody for Human Multidrug resistance-associated protein 6

Cat.:

P10404Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Multidrug resistance-associated protein 6

Monoclonal Antibody for Human Multidrug resistance-associated protein 6

Protein for Human Multidrug resistance-associated protein 6

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"MOAT-E (ARA) is a full-length MRP/cMOAT subfamily transporter expressed in kidney and liver."
Belinsky M.G. , Kruh G.D.
Br. J. Cancer80:1342-1349(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT VAL-848
2.

"Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells."
Kool M. , van der Linden M. , de Haas M. , Baas F. , Borst P.
Cancer Res.59:175-182(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS TRP-64 AND VAL-848
3.

"A cellular gene up-regulated by hepatitis B virus-encoded X antigen promotes hepatocellular growth and survival."
Lian Z. , Liu J. , Pan J. , Tufan N.L.S. , Zhu M. , Arbuthnot P. , Kew M. , Clayton M.M. , Feitelson M.A.
Hepatology34:146-157(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
4.

"Identification of a new splice variant of the human ABCC6 transporter."
Armentano M.F. , Ostuni A. , Infantino V. , Iacobazzi V. , Castiglione Morelli M.A. , Bisaccia F.
Biochem. Res. Int.2008:912478-912478(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3);VARIANTS VAL-319 AND VAL-848;ALTERNATIVE SPLICING
tissue: Liver.
5.

"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."
Loftus B.J. , Kim U.-J. , Sneddon V.P. , Kalush F. , Brandon R. , Fuhrmann J. , Mason T. , Crosby M.L. , Barnstead M. , Cronin L. , Mays A.D. , Cao Y. , Xu R.X. , Kang H.-L. , Mitchell S. , Eichler E.E. , Harris P.C. , Venter J.C. , more...
Genomics60:295-308(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS TRP-64 AND VAL-848
6.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANTS ALA-614; GLN-632 AND VAL-848
tissue: Retinoblastoma.
8.

"Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6)."
Ilias A. , Urban Z. , Seidl T.L. , Le Saux O. , Sinko E. , Boyd C.D. , Sarkadi B. , Varadi A.
J. Biol. Chem.277:16860-16867(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CHARACTERIZATION OF VARIANTS PXE PHE-1298; ARG-1302 AND SER-1321
9.

"Molecular genetics of pseudoxanthoma elasticum: a metabolic disorder at the environment-genome interface?"
Uitto J. , Pulkkinen L. , Ringpfeil F.
Trends Mol. Med.7:13-17(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;VARIANT PXE PRO-455
10.

"Subcellular localization and N-glycosylation of human ABCC6, expressed in MDCKII cells."
Sinko E. , Ilias A. , Ujhelly O. , Homolya L. , Scheffer G.L. , Bergen A.A. , Sarkadi B. , Varadi A.
Biochem. Biophys. Res. Commun.308:263-269(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TOPOLOGY;GLYCOSYLATION AT ASN-15
11.

"ABCC6 is a basolateral plasma membrane protein."
Pomozi V. , Le Saux O. , Brampton C. , Apana A. , Ilias A. , Szeri F. , Martin L. , Monostory K. , Paku S. , Sarkadi B. , Szakacs G. , Varadi A.
Circ. Res.112:E148-E151(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
12.

"The hepatitis B x antigen anti-apoptotic effector URG7 is localized to the endoplasmic reticulum membrane."
Ostuni A. , Lara P. , Armentano M.F. , Miglionico R. , Salvia A.M. , Monnich M. , Carmosino M. , Lasorsa F.M. , Monne M. , Nilsson I. , Bisaccia F.
FEBS Lett.587:3058-3062(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM 2);INDUCTION (ISOFORM 2);SUBCELLULAR LOCATION (ISOFORM 2)
13.

"Homozygosity for the R1268Q mutation in MRP6, the pseudoxanthoma elasticum gene, is not disease-causing."
Germain D.P. , Perdu J. , Remones V. , Jeunemaitre X.
Biochem. Biophys. Res. Commun.274:297-301(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLN-1268
14.

"Identification of two polymorphisms (c189G>C; c190T>C) in exon 2 of the human MRP6 gene (ABCC6) by screening of Pseudoxanthoma elasticum patients: possible sequence correction?"
Germain D.P. , Perdu J. , Remones V. , Manzoni K. , Jeunemaitre X.
Hum. Mutat.16:449-449(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TRP-64
15.

"Mutations of the gene encoding the transmembrane transporter protein ABC-C6 cause pseudoxanthoma elasticum."
Struk B. , Cai L. , Zaech S. , Ji W. , Chung J. , Lumsden A. , Stumm M. , Huber M. , Schaen L. , Kim C.-A. , Goldsmith L.A. , Viljoen D. , Figuera L.E. , Fuchs W. , Munier F. , Ramesar R. , Hohl D. , Richards R. , more...
J. Mol. Med.78:282-286(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PXE CYS-1339;VARIANT GLN-632
16.

"Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum."
Le Saux O. , Urban Z. , Tschuch C. , Csiszar K. , Bacchelli B. , Quaglino D. , Pasquali-Ronchetti I. , Pope F.M. , Richards A. , Terry S. , Bercovitch L. , de Paepe A. , Boyd C.D.
Nat. Genet.25:223-227(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PXE PRO-1114; GLN-1138 AND TRP-1314;VARIANT ALA-614
17.

"Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter."
Ringpfeil F. , Lebwohl M.G. , Christiano A.M. , Uitto J.
Proc. Natl. Acad. Sci. U.S.A.97:6001-6006(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PXE TRP-1138;VARIANT GLN-1268
18.

"A spectrum of ABCC6 mutations is responsible for pseudoxanthoma elasticum."
Le Saux O. , Beck K. , Sachsinger C. , Silvestri C. , Treiber C. , Goering H.H.H. , Johnson E.W. , De Paepe A. , Pope F.M. , Pasquali-Ronchetti I. , Bercovitch L. , Terry S. , Boyd C.D.
Am. J. Hum. Genet.69:749-764(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PXE LYS-411; GLN-518; SER-568; PRO-673; GLN-765; PRO-1114; TRP-1121; PRO-1138; GLN-1138; ASP-1203; PHE-1298; ILE-1301; ARG-1302; PRO-1303; GLN-1314; TRP-1314; SER-1321; CYS-1339; HIS-1347; ASN-1361 AND THR-1424;VARIANTS ASP-61; ARG-207; GLY-265; GLU-281; VAL-319; LYS-497; ALA-614; GLN-632; HIS-953; CYS-1241 AND GLN-1268
19.

"Identification of ABCC6 pseudogenes on human chromosome 16p: implications for mutation detection in pseudoxanthoma elasticum."
Pulkkinen L. , Nakano A. , Ringpfeil F. , Uitto J.
Hum. Genet.109:356-365(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PXE 60-ARG--TYR-62 DEL; ARG-364 AND ARG-1354;VARIANT GLY-265
20.

"ABCC6 gene polymorphism associated with variation in plasma lipoproteins."
Wang J. , Near S. , Young K. , Connelly P.W. , Hegele R.A.
J. Hum. Genet.46:699-705(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-614; GLN-632 AND GLN-1268
21.

"Does autosomal dominant pseudoxanthoma elasticum exist?"
Plomp A.S. , Hu X. , de Jong P.T. , Bergen A.A.
Am. J. Med. Genet. A126:403-412(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PXE CYS-1459
22.

"ABCC6 mutations in Italian families affected by pseudoxanthoma elasticum (PXE)."
Gheduzzi D. , Guidetti R. , Anzivino C. , Tarugi P. , Di Leo E. , Quaglino D. , Ronchetti I.P.
Hum. Mutat.24:438-439(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PXE ARG-364; LYS-411; GLY-440; GLN-518; CYS-600; MET-810; PRO-820; CYS-1114; MET-1130; GLN-1138; CYS-1339; SER-1346 AND LYS-1400
23.

"Novel ABCC6 mutations in pseudoxanthoma elasticum."
Chassaing N. , Martin L. , Mazereeuw J. , Barrie L. , Nizard S. , Bonafe J.L. , Calvas P. , Hovnanian A.
J. Invest. Dermatol.122:608-613(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PXE VAL-74 DEL; 363-GLN--ARG-373 DEL; GLY-391; GLN-518; ASP-766; MET-1130; GLN-1138 HIS-1238; PRO-1335 AND LYS-1400
24.

"Molecular genetics of pseudoxanthoma elasticum: type and frequency of mutations in ABCC6."
Miksch S. , Lumsden A. , Guenther U.P. , Foernzler D. , Christen-Zach S. , Daugherty C. , Ramesar R.K. , Lebwohl M. , Hohl D. , Neldner K.H. , Lindpaintner K. , Richards R.I. , Struk B.
Hum. Mutat.26:235-248(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PXE 60-ARG--TYR-62 DEL; GLU-129; ARG-317; ARG-355; ARG-364; ASP-370; GLY-391; GLY-398; HIS-495; GLN-518; SER-551; VAL-594; PRO-677; TRP-760; GLN-765; GLN-807; TRP-807; GLU-1056; PHE-1036 DEL; PHE-1048 DEL; CYS-1114; LEU-1121; GLN-1138; TRP-1138; GLN-1164; CYS-1221; TRP-1235; ARG-1302; PRO-1303; GLN-1314; CYS-1339; LEU-1339 AND TRP-1357;VARIANTS THR-78; LYS-125; VAL-158; GLY-265; GLU-281; VAL-319; ILE-514; ALA-614; GLN-632; LYS-724; VAL-742; ILE-946; TRP-1064 AND GLN-1268
25.

"Mutation detection in the ABCC6 gene and genotype-phenotype analysis in a large international case series affected by pseudoxanthoma elasticum."
Pfendner E.G. , Vanakker O.M. , Terry S.F. , Vourthis S. , McAndrew P.E. , McClain M.R. , Fratta S. , Marais A.S. , Hariri S. , Coucke P.J. , Ramsay M. , Viljoen D. , Terry P.F. , De Paepe A. , Uitto J. , Bercovitch L.G.
J. Med. Genet.44:621-628(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PXE 60-ARG--TYR-62 DEL; ARG-317; ARG-364; TRP-382; GLY-391; ASN-392; HIS-463 HIS-495; GLN-518; PRO-535; SER-568; CYS-600; CYS-663; PRO-698; ASP-699; PRO-726; LYS-751; ARG-755; TRP-760; GLN-765; ASN-777; MET-811; SER-881; ILE-944; THR-950; ARG-992; CYS-1114; MET-1130; ALA-1133; GLN-1138; TRP-1138; THR-1139; GLN-1164; CYS-1221; HIS-1221; ILE-1226; PHE-1298; ARG-1302; PRO-1303; GLN-1314; TRP-1314; GLN-1335; CYS-1339; HIS-1339 AND THR-1342
26.

"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome."
Ley T.J. , Mardis E.R. , Ding L. , Fulton B. , McLellan M.D. , Chen K. , Dooling D. , Dunford-Shore B.H. , McGrath S. , Hickenbotham M. , Cook L. , Abbott R. , Larson D.E. , Koboldt D.C. , Pohl C. , Smith S. , Hawkins A. , Abbott S. , more...
Nature456:66-72(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-1268
27.

"Spectrum of genetic variation at the ABCC6 locus in South Africans: Pseudoxanthoma elasticum patients and healthy individuals."
Ramsay M. , Greenberg T. , Lombard Z. , Labrum R. , Lubbe S. , Aron S. , Marais A.S. , Terry S. , Bercovitch L. , Viljoen D.
J. Dermatol. Sci.54:198-204(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PXE GLN-518; PRO-726; GLN-1138; ARG-1302; PRO-1335 AND CYS-1339;VARIANTS THR-78; GLY-265; MET-417; ALA-614; GLN-632; LEU-724; VAL-742; VAL-848 AND ILE-946
28.

"An unusual severe vascular case of pseudoxanthoma elasticum presenting as generalized arterial calcification of infancy."
Le Boulanger G. , Labreze C. , Croue A. , Schurgers L.J. , Chassaing N. , Wittkampf T. , Rutsch F. , Martin L.
Am. J. Med. Genet. A152:118-123(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PXE GLN-765 AND LYS-1406
29.

"Generalized arterial calcification of infancy and pseudoxanthoma elasticum can be caused by mutations in either ENPP1 or ABCC6."
Nitschke Y. , Baujat G. , Botschen U. , Wittkampf T. , du Moulin M. , Stella J. , Le Merrer M. , Guest G. , Lambot K. , Tazarourte-Pinturier M.F. , Chassaing N. , Roche O. , Feenstra I. , Loechner K. , Deshpande C. , Garber S.J. , Chikarmane R. , Steinmann B. , more...
Am. J. Hum. Genet.90:25-39(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GACI2 ARG-355; GLY-391; PHE-590; PHE-1036 DEL; CYS-1114; HIS-1221 AND TRP-1314

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